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Phase angle and donor type are determinants of coronary artery calcification in stable kidney transplant recipients at twelve months after transplantation Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-18 Fernanda G. Rodrigues, Megan S.M. Bruins, Rozemarijn Vliegenthart, Daan Kremer, Camilo G. Sotomayor, Ilja M. Nolte, Udo Douwe J. Mulder, Gerjan J. Navis, Ita Pfeferman Heilberg, Robert A. Pol, Stephan J.L. Bakker, TransplantLines Investigators, Martin H. de Borst, Charlotte A. Te Velde-Keyzer
Coronary artery calcification (CAC) partially explains the excess cardiovascular morbidity and mortality after kidney transplantation. This study aimed to investigate determinants of CAC in stable kidney transplant recipients at 12 months post-transplantation. CAC-score was quantified by the Agatston method using non-contrast enhanced computed tomography, and age- and sex-standardized CAC-percentiles
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Effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and cardiovascular disease: A meta-analysis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-18 Sen Liu, Jindong Wan, Dan Wang, Yi Yang, Jie Fang, Tao Luo, Dengpan Liang, Jun Hu, Jixin Hou, Peijian Wang
The impact of the loss-of-function (LOF) genetic variant PCSK9 R46L on glucose homeostasis and cardiovascular disease (CVD) remains uncertain, despite its established correlation with diminished blood cholesterol levels. This meta-analysis aimed at exploring the effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and CVD. PubMed, Embase, and the
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Genetically predicted biomarkers of iron homeostasis and risk of non-ischemic cardiomyopathy: A mendelian randomization study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-16 Hao Huang, Xueying Wang, Yu Yu, Sijing Cheng, Tianxin Long, Hongxia Niu, Wei Hua
Both iron overload and iron deficiency have been associated with cardiovascular diseases in observational studies. Previous Mendelian Randomization (MR) studies discovered a protective effect of higher iron status on coronary atrial disease, while a neutral effect on all-cause heart failure. Using two-sample MR, we evaluated how genetically predicted systemic iron status affects the risk of non-ischemic
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Statin use, albuminuria, and mortality risk: Re-evaluating C-reactive protein to albumin ratio in hypertensive patients based on NHANES data Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-14 Kuo-Chin Hung, Chia-Ter Chao
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Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-13 Waleska Dornas, Maisa Silva
The enzyme paraoxonase 1 (PON1) bound to high-density lipoprotein has received special attention for its protective role against stress-mediated damage and use as a potential regulatory target in atherosclerosis and related vascular diseases. We present an overview of the literature on PON1 activity and mRNA levels by investigating its modulation for clinical translations. Specifically, the expression
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Influence of cardiorespiratory fitness on obesity-associated inflammation in women and men: The FATCOR study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-12 Helga Midtbø, Arve Ulvik, Dana Cramariuc, Klaus Meyer, Per M. Ueland, Hilde Halland, Eva Gerdts
Cardiorespiratory fitness has been postulated to lower chronic inflammation in obesity. We assessed sex-specific associations of inflammation with cardiorespiratory fitness in overweight and obese persons. Peak oxygen uptake (VO) was measured by treadmill in 566 participants (age 48 ± 9 years, 60% women) with body mass index >27.0 kg/m in the FAT associated CardiOvasculaR dysfunction (FATCOR) study
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Triglyceride-glucose index and mortality risk in individuals with or without chronic kidney disease: Insights from a national survey of United States adults, 1999–2018 Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-10 Yi Qin, Liping Xuan, Yujie Deng, Fei Wang, Bin Liu, Shujie Wang
The Triglyceride-Glucose Index (TyG) has been proposed as a predictor to mortality, yet its association remains incompletely understood for individuals with or without chronic kidney disease (CKD). We analyzed data from the National Health and Nutrition Examination Survey spanning the years 1999–2018. CKD was defined as eGFR level <60 ml/min/1.73 m or urinary albumin creatinine ratio ≥30 mg/g. We employed
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Association between metabolic phenotypes of overweight/obesity and cardiovascular diseases in postmenopausal women Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-05 Danying Deng, Zhiqiang Nie, Jiabin Wang, Chaolei Chen, Wenbin Wang, Yanchen Zhu, Qingyu Guan, Yanqiu Ou, Yingqing Feng
Obesity and metabolic abnormalities were associated with an increased risk of cardiovascular diseases. However, it is unclear how metabolic weight phenotypes relate to cardiovascular diseases in postmenopausal women. This study aimed to explore the relationships in postmenopausal women. We included 15,575 postmenopausal women aged 35–75 years (median age, 60.6) without cardiovascular disease at baseline
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Trends in cardiovascular health metrics and associations with long-term mortality among US adults with coronary heart disease Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-05 Qingping Xue, Shiyi Wu, Xingchen He, Yuli Huang, Yanjun Liu, Tong Yan, Nianwei Wu, Xue Yang, Ying Wen, Sheyu Li, Lauryn Cravens, Chun-Xia Yang, Jason H.Y. Wu, An Pan, Xiaohong Yang, Xiong-Fei Pan
Our study examined the trends of cardiovascular health metrics in individuals with coronary heart disease (CHD) and their associations with all-cause and cardiovascular disease mortality in the US. The cohort study was conducted based on the National Health and Nutrition Examination Survey 1999–2018 and their linked mortality files (through 2019). Baseline CHD was defined as a composite of self-reported
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Maternal glycaemic levels are associated with incidence of large for gestational age neonates in type 1 diabetic women in pregnancy Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-04-05 Alessandro Roberto Dodesini, Elena Ciriello, Rosalia Bellante, Anna Corsi, Monica Rosaria Giunta, Cristiana Scaranna, Mascia Albizzi, Giuseppe Lepore, Roberto Trevisan
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Arterial stiffness progression in metabolic dysfunction–associated fatty liver disease subtypes: A prospective cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-30 Lei Liu, Yufu Zhou, Shuwen Deng, Ting Yuan, Saiqi Yang, Xiaoling Zhu, Changfa Wang, Yaqin Wang
We aimed to investigate the correlation and to explore which MAFLD subtypes have the greatest influence on progression of arterial stiffness risk. Using data from a health examination-based cohort, a total of 12,129 participants who underwent two repeated health examinations that included brachial-ankle pulse wave velocity (baPWV) from 2012 to 2020 were enrolled. Participants were separated into non–MAFLD
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Baseline urinary osteopontin levels are associated with the improvement of metabolic syndrome Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-29 Margherita Moriero, Daniela Verzola, Maria Bertolotto, Silvia Minetti, Paola Contini, Davide Ramoni, Luca Liberale, Roberto Pontremoli, Francesca Viazzi, Aldo Pende, Livia Pisciotta, Fabrizio Montecucco, Federico Carbone
While serum osteopontin (OPN)'s established role in cardiometabolic risk is recognized, its potential as a predictor of metabolic syndrome (MetS) improvement through a urine assay has not yet been demonstrated. In this study, we propose its potential predictive role over a 12-month period of standard care, with the ability to complement anthropometric measures. Hierarchical clustering revealed a notable
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Left atrial size modify the association between uric acid and atrial fibrillation in patients with coronary artery disease Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-29 Xuefeng Wu, Zhaoyan Xu, Xili Yang, Jianming Li, Yingqing Feng
The potential influence of left atrial size on the relationship between uric acid and atrial fibrillation has not been fully investigated. This study aims to evaluate the interaction effect of left atrial size on the association between uric acid and atrial fibrillation in patients with coronary artery disease. This retrospective cohort study, conducted from January 2018 to October 2022, included 2004
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Associations of iron metabolism and inflammation with all-cause and cardiovascular mortality in a large NHANES community sample: Moderating and mediating effects Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-27 Yaoting Zhang, Bing Li, He Cai, Yu Fu, Yang Zheng
This study aimed to assess the associations between serum iron concentration, C-reactive protein (CRP) concentration and the risk of all-cause mortality and cardiovascular mortality in the general population and to explore potential mediating and moderating effects. This study analyzed data from the National Health and Nutrition Examination Survey spanning the years 1999–2010, encompassing 23,634 participants
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Predictability of noninvasive liver fibrosis score for cardiac events in patients with nonalcoholic fatty liver disease Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-27 Naoki Shibata, Takanori Ito, Hidenori Toyoda, Akihito Tanaka, Yasuhiro Morita, Yasunori Kanzaki, Naoki Watanabe, Naoki Yoshioka, Satoshi Yasuda, Itsuro Morishima
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Association of cardiovascular health metrics with all-cause and cardiovascular disease mortality in CKD: A cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-23 Shanshan Zhang, Qingping Xue, Di Li, Ying Xu, Yan-Bo Zhang, Jieru Peng, Shiyi Wu, Xingchen He, Xue Yang, Yanjun Liu, Tong Yan, Nianwei Wu, Ying Wen, Lauryn Cravens, Jason HY. Wu, Chun-Xia Yang, Xiong-Fei Pan
Since the global burden of chronic kidney disease (CKD) is rising rapidly, the study aimed to assess the association of cardiovascular health (CVH) metrics with all-cause and cardiovascular disease (CVD) mortality among individuals with CKD. The cohort study included 5834 participants with CKD from the National Health and Nutrition Examination Survey 1999–2018. A composite CVH score was calculated
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Treatment intensification following glucagon-like Peptide-1 receptor agonist in type 2 diabetes: Comparative effectiveness analyses between free vs. fixed combination of GLP-1 RA and basal insulin. RESTORE-G real-world study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-23 Riccardo Candido, Antonio Nicolucci, Monica Larosa, Maria Chiara Rossi, Raffaele Napoli, RESTORE-G (Retrospective analysis on the therapeutic approaches after GLP1-RA treatment in type 2 diabetes patients) Study Group, Enrico Gabellieri, Elena Tortato, Rosa Anna Rabini, Dalia Crazzolara, Luigi Lucibelli, Concetta Aragiusto, Gianluigi Panzolato, Maurizio Di Mauro, Andrea Del Buono, Giuseppe Placentino
Add-on of basal insulin (BI) to intensify the ongoing therapy with glucagon-like peptide 1 receptor agonist (GLP-1 RA) is recommended, but it is unclear if free or fixed combination of BI and GLP-1 RA produce similar outcomes. A retrospective comparative effectiveness analysis of the add-on of glargine 300 U/mL (Gla-300) to ongoing GLP-1 RA vs. switch to fixed ratio combination of degludec and liraglutide
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Longitudinal associations of the alternative healthy eating index with coronary artery calcification and pericardial adiposity in US adults with and without type 1 diabetes Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-20 Leigh Ann Richardson, Arpita Basu, Lung-Chang Chien, Tiantian Pang, Amy C. Alman, Janet K. Snell-Bergeon
Long-term associations between the alternative healthy eating index (AHEI) score and two predictive indicators for CVD, pericardial adipose tissue (PAT) and coronary artery calcification (CAC) volume, are lacking. Our study aims to investigate the longitudinal associations of the AHEI score with measures of CAC and PAT in adults with and without type 1 diabetes (T1D). The prospective Coronary Artery
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Dietary inflammatory potential and arterial stiffness in a French cohort: Insights from the STANISLAS study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-20 Agbo Louis-Désiré, Nicolas Girerd, Zohra Lamiral, Kevin Duarte, Erwan Bozec, Ludovic Merckle, Axelle Hoge, Michèle Guillaume, Martine Laville, Julie-Anne Nazare, Patrick Rossignol, Jean-Marc Boivin, Sandra Wagner
Chronic inflammation plays a key role in arterial stiffness pathogenesis. Dietary components can display anti- or pro-inflammatory properties. Nonetheless, the association between the diet's overall inflammatory potential and arterial stiffness is unclear. This study aimed to assess the association between the diet's overall inflammatory potential and arterial stiffness assessed by carotid-femoral
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The dysfunctional adiposity index is a clinical surrogate of pericardial fat in adults without premature CVD: A sub-analysis of the GEA Mexican study control group Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-19 Juan Reyes-Barrera, Neftali Eduardo Antonio-Villa, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcón, Aida X. Medina-Urrutia
The Dysfunctional Adiposity Index (DAI) is a clinical surrogate for evaluating adipose tissue functionality and cardiometabolic health. However, its association with Pericardial Fat Volume (PFV) has not been tested. Evaluate DAI- PFV association, stratified by type 2 diabetes (T2D) status, and identify DAI thresholds for detecting increased PFV among patients without premature CVD. Participants from
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Body surface scan anthropometrics are associated with grip strength in the general population Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-19 Berit Filges, Martin Bahls, Dörte Radke, Stefan Groß, Ralf Ewert, Beate Stubbe, Marcello RP. Markus, Stephan B. Felix, Henry Völzke, Marcus Dörr, Armin Köhler, Till Ittermann
Body shape and anthropometrics are well-known risk factors for cardiovascular disease (CVD) and mortality. Hand-grip strength (HGS) is also a meaningful marker of health and a promising predictor of CVD and mortality. There is a lack of studies that have systematically investigated associations between body shape and anthropometrics with HGS. In a population-based study, we investigated if anthropometric
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Association of hyperuricemia with metabolic syndrome and its components in an adult population of Faisalabad, Pakistan Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-16 Rameen Shahid, Misbah Hussain, Muhammad Umer Ghori, Ahmed Bilal, Fazli Rabbi Awan
The rising prevalence of metabolic syndrome (MetS) is a matter of serious concern worldwide. Hyperuricemia has been observed as an independent risk factor in the development of MetS and each of its individual components in different populations. This study aims to determine the association of hyperuricemia with MetS and its individual components in a Pakistani cohort. A cross-sectional study was performed
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Association between body composition and subsequent cardiovascular diseases among 5-year breast cancer survivors Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-15 Ji Soo Kim, Jihun Song, Seulggie Choi, Sung Min Kim, Young Jun Park, Sun Jae Park, Yoosun Cho, Yun Hwan Oh, Seogsong Jeong, Kyae Hyung Kim, Sang Min Park
Cardiovascular disease (CVD) remain one of the leading causes of mortality in breast cancer survivors. This study aimed to investigate the association between body composition and subsequent CVD in breast cancer survivors. A retrospective cohort study of more than 70 thousand 5-year breast cancer survivors aged 40 years or older was conducted using data from the National Health Insurance Service of
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Serum phosphorus concentration and its association with the degree and pattern of intracranial arterial calcification Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-15 Xuelong Li, Heng Du, Yangyang Cheng, Xianliang Li, Qingchun Gao, Xiangyan Chen
The aim of this study was to determine whether the serum phosphorus concentrations (SPC) are associated with the degree and pattern of intracranial arterial calcification (IAC) in patients with normal renal function or mild-moderate renal impairment. A total of 513 patients were enrolled in this study. The degree of IAC measured by IAC scores was evaluated on non-contrast head computed tomography (CT)
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Association of secondhand smoke exposure with all-cause mortality and cardiovascular death in patients with hypertension: Insights from NHANES Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-14 Dikang Pan, Julong Guo, Sensen Wu, Hui Wang, Jingyu Wang, Cong Wang, Yongquan Gu
The impact of environmental chemical exposure on blood pressure (BP) is well-established. However, the relationship between secondhand smoke exposure (SHSE) and mortality in hypertensive patients in the general population remains unclear. This cohort study included US adults in the National Health and Nutrition Examination Survey from 2007 to 2018. All-cause mortality and cause-specific mortality outcomes
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Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-14 Fernanda Carrasco-Marín, Longgang Zhao, James R. Hébert, Michael D. Wirth, Fanny Petermann-Rocha, Nathan Phillips, Fiona C. Malcomson, John C. Mathers, Lyn D. Ferguson, Frederik Ho, Jill Pell, Carlos Celis-Morales, Guillermo Molina-Recio, Rafael Molina-Luque
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Association between plasma maresin 1 and the risk of atherosclerotic cardiovascular disease in Chinese adults: A community-based cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-13 Mengyuan Li, Yajun Sun, Bingyue Liu, Yong Xue, Mengya Zhu, Kexin Zhang, Yang Jing, Hongzhan Ding, Yanyu Liang, Hui Zhou, Chen Dong
It has been reported that maresin 1 (MaR1) is able to protect against the development of atherogenesis in cellular and animal models. This study was performed to investigate whether plasma MaR1 is associated with the risk of atherosclerotic cardiovascular disease (ASCVD) at the population level. The study included 2822 non-ASCVD participants from a community-based cohort who were followed for about
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Asymmetric and symmetric dimethylarginine as markers of endothelial dysfunction in cerebrovascular disease: A prospective study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-13 Chiara Bima, Mirko Parasiliti-Caprino, Francesca Rumbolo, Federico Ponzetto, Iacopo Gesmundo, Antonello Nonnato, Paolo Fornengo, Giovanna Vaula, Ezio Ghigo, Giulio Mengozzi, Fabio Settanni
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) have been proposed as mediators of endothelial dysfunction. In this study, we aimed to investigate the diagnostic and prognostic role of ADMA and SDMA in acute cerebrovascular disease. A prospective case-control study was performed, enrolling 48 patients affected by ischemic stroke with no cardioembolic origin, 20 patients affected
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Association of short-chain fatty acids and the gut microbiome with type 2 diabetes: Evidence from the Henan Rural Cohort Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-13 Tianyu Yang, Cuiping Wu, Yuqian Li, Chongjian Wang, Zhenxing Mao, Wenqian Huo, Jia Li, Yan Li, Wenguo Xing, Linlin Li
Human studies about short-chain fatty acids (SCFAs), the gut microbiome, and Type 2 diabetes (T2DM) are limited. Here we explored the association between SCFAs and T2DM and the effects of gut microbial diversity on glucose status in rural populations. We performed a cross-sectional study from the Henan Rural Cohort and collected stool samples. Gut microbiota composition and faecal SCFA concentrations
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Influence of MAFLD and NAFLD on arterial stiffness: A longitudinal cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-13 Tae Kyung Yoo, Seung Wook Lee, Mi Yeon Lee, Hanna Choi, Ki-Chul Sung
This cohort study investigated associations of nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction–associated fatty liver disease (MAFLD) with risk of increase in arterial stiffness (AS), measured as brachial-ankle pulse wave velocity (baPWV). Participants who had health examinations between 2006 and 2019 were analyzed for fatty liver and increased baPWV using liver ultrasonography and
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Dietary advanced glycation end products, body composition, and anthropometric measures: A cross-sectional analysis in women with excess body weight Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-12 Nélia P. Mendes, Flávia G. Cândido, Flávia X. Valente, Maria do Carmo G. Peluzio, Leidjaira L. Juvanhol, Rita C.G. Alfenas
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The consumption of animal products is associated with plasma levels of alpha-aminoadipic acid (2-AAA) Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-12 Olivia R. Antonetti, Stacy Desine, Holly M. Smith, Michelle E. Robles, Ezelle McDonald, Gerry Ovide, Chuan Wang, E. Danielle Dean, Amanda C. Doran, M. Wade Calcutt, Shi Huang, Jonathan D. Brown, Heidi J. Silver, Jane F. Ferguson
The cardiometabolic disease-associated metabolite, alpha-aminoadipic acid (2-AAA) is formed from the breakdown of the essential dietary amino acid lysine. However, it was not known whether elevated plasma levels of 2-AAA are related to dietary nutrient intake. We aimed to determine whether diet is a determinant of circulating 2-AAA in healthy individuals, and whether 2-AAA is altered in response to
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Unused potential of lipid-lowering therapy in very high-risk patients with atherosclerotic cardiovascular disease - A retrospective data analysis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-11 Sarah B. Pohl, Christiane Engelbertz, Holger Reinecke, Nasser M. Malyar, Matthias Meyborg, Tobias J. Brix, Julian Varghese, Katrin Gebauer
Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of death in Europe. Although the 2019 European Society of Cardiology/European Atherosclerosis Society Guidelines for the management of dyslipidaemias claim a target low-density lipoprotein cholesterol (LDL-C) value of <55 mg/dL for very high-risk patients by use of lipid-lowering therapy (LLT) and lifestyle adaptations, the target
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Sex differences in the association of the uric acid to high-density lipoprotein cholesterol ratio with coronary artery disease risk among Chinese nondialysis patients with CKD stages 3–5 Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-09 Yan Yang, Xiao-yan Shen, Hai-xia Tang, Hong Liu, Yi Wen
Evidence has indicated that serum uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) are positively and negatively associated with coronary artery disease (CAD). The UA to HDL-C ratio (UHR) has recently drawn attention as a new predictor for metabolic syndrome, inflammation and atherosclerosis. However, the association between the UHR and CAD in nondialysis chronic kidney disease (CKD)
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Eating habits and sleep quality in individuals with type 1 diabetes on continuous glucose monitoring and insulin pump Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-08 Alessandra Corrado, Giuseppe Scidà, Marilena Vitale, Benedetta Caprio, Giuseppina Costabile, Eric Annuzzi, Giuseppe Della Pepa, Roberta Lupoli, Lutgarda Bozzetto
Sleep disorders are bidirectionally linked with eating behaviors and glucose metabolism, which could be clinically relevant in type 1 diabetes (T1D). We investigated the relationship between dietary habits and sleep quality in individuals with T1D on insulin pumps and continuous glucose monitoring (CGM). In a cross-sectional study, dietary habits (7-day food diary, EPIC questionnaire) and sleep quality
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A high level of uric acid is associated with long-term adverse cardiovascular outcomes in patients who received fractional flow reserve with coronary intermediate stenosis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-08 Fanqi Li, Qiuzhen Lin, Jiabao Zhou, Jiayi Zhu, Yong Zhou, Keke Wu, Qiuyu Li, Donghui Zhao, Qiming Liu
The role of fractional flow reserve (FFR) in coronary intermediate lesions is widely recommended by guidelines. The effect of uric acid (UA) on cardiovascular events is also well known. However, the relationship between UA and long-term cardiovascular outcomes in patients who received FFR with intermediate lesions remains unknown. We retrospectively included 428 patients who underwent both coronary
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Use of ancient grains for the management of diabetes mellitus: A systematic review and meta-analysis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-07 Camilla Elena Magi, Laura Rasero, Edoardo Mannucci, Guglielmo Bonaccorsi, Francesco Ranaldi, Luigia Pazzagli, Paola Faraoni, Nadia Mulinacci, Stefano Bambi, Yari Longobucco, Ilaria Dicembrini, Paolo Iovino
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Genetic correlations between liver fat content, metabolic health, and adiposity distribution in the Fels Longitudinal Study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-06 Ariana L. Garza, Miryoung Lee, John Blangero, Cici X. Bauer, Stefan A. Czerwinski, Audrey C. Choh
Hepatic steatosis is known to be heritable, but its genetic basis is mostly uncharacterized. Steatosis is associated with metabolic and adiposity features; recent studies hypothesize that shared genetic effects between these traits could account for some of the unexplained heritability. This study aimed to quantify these genetic associations in a family-based sample of non-Hispanic white adults. 704
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Ultra-processed food consumption and cardiovascular events rate: An analysis from Isfahan Cohort Study (ICS) Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-06 Mohammad Kermani-Alghoraishi, Amin Behrouzi, Razieh Hassannejad, Nizal Sarrafzadegan, Fatemeh Nouri, Mansoureh Boshatam, Hamidreza Roohafza, Fahimeh Haghighatdoost, Masoumeh Sadeghi
The contribution of ultra-processed foods (UPFs) to daily energy intake and, therefore, their health effects may vary between countries. We aimed to investigate the association between UPFs and the incidence risk of cardiovascular events (CVEs) and cardiovascular mortality in the Isfahan cohort study. In 2001, 6504 participants aged ≥35 years were enrolled and followed until 2017. Dietary intake was
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Moderate-intensity constant or high-intensity interval training? Metabolic effects on candidates to undergo bariatric surgery Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-05 Javier Enríquez-Schmidt, Camila Mautner Molina, Mariana Kalazich Rosales, Maximiliano Muñoz, Matias Ruiz-Uribe, Francisca Fuentes Leal, Manuel Monrroy Uarac, Carlos Cárcamo Ibaceta, Daniel J. Fazakerley, Mark Larance, Pamela Ehrenfeld, Sergio Martínez-Huenchullán
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Development of a machine learning-based model for predicting individual responses to antihypertensive treatments Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-03-04 Jiayi Yi, Lili Wang, Jiali Song, Yanchen Liu, Jiamin Liu, Haibo Zhang, Jiapeng Lu, Xin Zheng
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BMI-based metabolic syndrome severity score and arterial stiffness in a cohort Chinese study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-29 Miao Wang, Chi Wang, Maoxiang Zhao, Shouling Wu, Hao Xue, Hongbin Liu
To investigate the relationship between metabolic syndrome severity z score(MetS-Z) and arterial stiffness(AS). A total of 7621 participants who took three physical examination and brachial-ankle pulse wave velocity(ba-pwv) test from 2006 were enrolled. Cumulative MetS-Z(cMetS-Z) was calculated by using blood pressure, triglycerides, HDL cholesterol, blood glucose and BMI. AS was assessed by ba-pwv
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Causal effect of serum 25 hydroxyvitamin D concentration on cardioembolic stroke: Evidence from two-sample Mendelian randomization Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-28 Danial Habibi, Farshad Teymoori, Navid Ebrahimi, Sahand Tehrani Fateh, Leila Najd-Hassan-Bonab, Amir Hossein Saeidian, Alireza Soleymani Taloubaghi, Sara Asgarian, Farhad Hosseinpanah, Hakon Hakonarson, Fereidoun Azizi, Mehdi Hedayati, Maryam Sadat Daneshpour, Mahdi Akbarzadeh, Marjan Mansourian
The putative association between serum 25-hydroxyvitamin D concentration [25(OH)D] and the risk of cardioembolic stroke (CES) has been examined in observational studies, which indicate controversial findings. We performed Mendelian randomization (MR) analysis to determine the causal relationship of serum 25(OH)D with the risk of CES. The summary statistics dataset on the genetic variants related to
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The relationship between C-reactive protein/albumin ratio and mortality in hypertensive patients: A national cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-27 Rongting Zhang, Yani Wang, Lihua Liao, Ying Liao, Yong Fang, Yunli Shen
The impact of inflammation on the prognosis of hypertension has received some attention. The current study examined the association between C-reactive protein to albumin ratio (CAR), a novel indicator of inflammatory response, and mortality in individuals with hypertension. A total of 9561 eligible individuals diagnosed with hypertension were included in the final analysis. CAR was calculated as ratio
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Outdoor gardening activity with different frequency and duration may be associated with reduction of total and cause-specific mortality risk for general U.S adults: Findings from the NHANES Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-26 Jing-hong Liang, Mei-ling Liu, Shao-yi Huang, Shan Huang, Ying-qi Pu, Nan Jiang, Wen-wen Bao, Yu-shan Zhang, Zhao-huan Gui, Li-xin Hu, Xue-ya Pu, Jing Li, Ya-jun Chen
Engaging in recommended levels of physical activity (PA) is associated with a reduced overall mortality rate and cause-specific mortality rates. Our study aims to examine the relationship between gardening-specific PA and all-cause and cause-specific mortality based on representative U.S. adults. A total of 13,812 adults representing 663.5 million non-institutionalized U.S. adults were included in
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Circulatory levels of lysophosphatidylcholine species in obese adolescents: Findings from cross-sectional and prospective lipidomics analyses Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-23 Sapna Sharma, Yalamanchili Venkata Subrahmanyam, Harish Ranjani, Sidra Sidra, Dharmeshkumar Parmar, Sangeetha Vadivel, Shanthini Kannan, Harald Grallert, Dandamudi Usharani, Ranjit Mohan Anjana, Muthuswamy Balasubramanyam, Viswanathan Mohan, Adamski Jerzy, Venkateswarlu Panchagnula, Kuppan Gokulakrishnan
Obesity has reached epidemic proportions, emphasizing the importance of reliable biomarkers for detecting early metabolic alterations and enabling early preventative interventions. However, our understanding of the molecular mechanisms and specific lipid species associated with childhood obesity remains limited. Therefore, the aim of this study was to investigate plasma lipidomic signatures as potential
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Persistence of vitamin D deficiency among Italian patients with acute myocardial infarction Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-22 Aneta Aleksova, Milijana Janjusevic, Xin Ning Oriana Zhou, Lorenzo Zandonà, Andrea Chicco, Elisabetta Stenner, Antonio Paolo Beltrami, Stefano D'Errico, Gianfranco Sinagra, Maria Marketou, Alessandra Lucia Fluca, Donna R. Zwas
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Association of cardiometabolic and triglyceride-glucose index with left ventricular diastolic function in asymptomatic individuals Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-20 Runyu Ye, Xin Zhang, Zhipeng Zhang, Si Wang, Lu Liu, Shanshan Jia, Xiangyu Yang, Xueting Liu, Xiaoping Chen
Obesity and insulin resistance are associated with left ventricular diastolic dysfunction (LVDD) and increased risk of heart failure. Cardiometabolic index (CMI) and triglyceride glucose (TyG) are new indexes to assess visceral obesity and insulin resistance, respectively. The study aimed to investigate the clinical usefulness of these indexes for identifying LVDD individuals. Overall, 1898 asymptomatic
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Long-term clinical outcomes and management of hypertriglyceridemia in children with Apo-CII deficiency Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-17 Merve Yoldas Celik, Ebru Canda, Havva Yazici, Fehime Erdem, Ayse Yuksel Yanbolu, Yasemin Atik Altinok, Erhan Pariltay, Haluk Akin, Sema Kalkan Ucar, Mahmut Coker
APO CII, one of several cofactors which regulate lipoprotein lipase enzyme activity, plays an essential role in lipid metabolism. Deficiency of APO CII is an ultra-rare autosomal recessive cause of familial chylomicronemia syndrome. We present the long-term clinical outcomes of 12 children with APO CII deficiency. The data of children with genetically confirmed APO CII deficiency were evaluated retrospectively
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The effect of observing religious or faith-based fasting on cardiovascular disease risk factors: A systematic review and meta-analysis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-16 Negin Gholampoor, Amir Hossien Sharif, Duane Mellor
Cardiovascular diseases (CVD) are the leading cause of death worldwide. Fasting is common in many religions and is associated with health benefits. This systematic review to compares the impact of different religious fasting practices, on risk of cardiometabolic diseases. The search covered five databases following PRISMA guidelines to identify papers published in English from inception to March 2023
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Establishment of a machine learning predictive model for non-alcoholic fatty liver disease: A longitudinal cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-15 Tengrui Cao, Qian Zhu, Chao Tong, Aheyeerke Halengbieke, Xuetong Ni, Jianmin Tang, Yumei Han, Qiang Li, Xinghua Yang
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, which lacks effective drug treatments. This study aimed to construct an eXtreme Gradient Boosting (XGBoost) prediction model to identify or evaluate potential NAFLD patients. We conducted a longitudinal study of 22,140 individuals from the Beijing Health Management Cohort. Variable filtering was performed using the least absolute
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Association of serum 25-hydroxyvitamin D concentration with all-cause and cause-specific mortality in hypertensive patients Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-15 Dikang Pan, Huan Qiao, Hui Wang, Sensen Wu, Jingyu Wang, Cong Wang, Jianming Guo, Yongquan Gu
To examine the association of serum 25-hydroxyvitamin D [25(OH)D] with all-cause mortality and disease-specific mortality in patients with hypertension. This cohort study included US adults in the National Health and Nutrition Examination Survey from 2007 to 2018. All-cause mortality and cause-specific mortality outcomes were determined by association with National Death Index records. Cox proportional
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Food intake, plasma copeptin and cardiovascular risk in patients with type 2 diabetes: A cross-sectional analysis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-07 Cíntia C. Real Rodrigues, Daisy Crispim, Fernanda M. Busnello, Viviane Sahade, Daniela Correa, Tainara A. dos Santos, Angela C. Bersch-Ferreira, Aline Marcadenti, Jussara C. de Almeida
Increased consumption of ultra-processed foods has been linked to both mortality and cardiovascular risk. Copeptin levels may serve as potential risk markers for cardiovascular death and events. This cross-sectional analysis seeks to assess the potential correlation between the intake of ultra-processed foods and copeptin levels in outpatients diagnosed with type 2 diabetes, based on estimates of cardiovascular
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Metabolomics of human umbilical vein endothelial cell-based analysis of the relationship between hyperuricemia and dyslipidemia Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-07 Wen Huang, Min Zhang, Qiong Qiu, Jing Zhang, Chao Hua, Geliang Chen, Hua Xie
Hyperuricemia frequently accompanies dyslipidemia, yet the precise mechanism remains elusive. Leveraging cellular metabolomics analyses, this research probes the potential mechanisms wherein hyperuricemia provokes endothelial cell abnormalities, inducing disordered bile metabolism and resultant lipid anomalies. We aimed to identify the differential metabolite associated with lipid metabolism through
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Request of errata corrige for paper: “Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level” Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-07 Paolo Palatini
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Associations between bone mineral density and abdominal aortic calcification: Results of a nationwide survey Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-07 Ran Wei, Yixin Zhang, Maoxun Huang, Hulin Piao, Zhaoxuan Gu, Cuilin Zhu
Vascular calcification has been linked to bone mineral density (BMD). This study aimed to investigate the association between BMD and abdominal aortic calcification (AAC). Data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) were utilized. Participants lacking BMD and AAC score data were excluded. BMD at the femoral neck was measured using dual-energy X-ray absorptiometry
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Impact of fibre supplementation on microbiome and resilience in healthy participants: A randomized, placebo-controlled clinical trial Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-06 Boukje C. Eveleens Maarse, Hannah M. Eggink, Ines Warnke, Sabina Bijlsma, Tim J. van den Broek, Johanneke E. Oosterman, Martien P.M. Caspers, Wilbert Sybesma, Pim Gal, Sebastiaan J.W. van Kraaij, Frank H.J. Schuren, Matthijs Moerland, Femke P.M. Hoevenaars
The gut microbiome exerts important roles in health, e.g., functions in metabolism and immunology. These functions are often exerted via short-chain fatty acid (SCFA) production by gut bacteria. Studies demonstrating causal relationships between interventions targeting the microbiome and clinical outcomes are limited. This study aimed to show a causal relationship between microbiome modulation through
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Association of serum uric acid with all-cause and cardiovascular mortality in chronic kidney disease stages 3–5 Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-06 Jinguo Yuan, Jin Zhao, Yunlong Qin, Yan Xing, Zixian Yu, Yumeng Zhang, Hao Wu, Qiao Zheng, Yueqing Hui, Shuxian Guo, Anjing Wang, Mei Han, Xiaoxuan Ning, Shiren Sun
The role of serum uric acid (SUA) in the prognosis of chronic kidney disease (CKD) is inconclusive. To explore the association of SUA level with all-cause and cardiovascular disease (CVD) mortality in patients with CKD. Leveraging data from the National Health and Nutritional Examination Survey (NHANES) and linked national death records up to December 31 2019, we explored the association of SUA with
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The combination of high uric acid and high C-reactive protein increased the risk of cardiovascular disease: A 15-year prospective cohort study Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-05 Na Li, Shouling Wu, Rong Shu, Haicheng Song, Jierui Wang, Shuohua Chen, Wenhao Yang, Guodong Wang, Jingtao Yang, Xuemei Yang, Gary Tse, Nan Zhang, Liufu Cui, Tong Liu
Uric acid (UA) and C-reactive protein (CRP) may interact synergistically to accelerate the initiation and progression of cardiovascular disease (CVD). This study investigated the effects of a combination of high UA and high CRP on the risks of CVD. A total of 90,270 participants recruited from the Kailuan study were included, who were divided into four groups according to the presence/absence of hyperuricemia
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No causal association between serum vitamin D levels and diabetes retinopathy: A Mendelian randomization analysis Nutr. Metab. Cardiovascular Dis. (IF 3.9) Pub Date : 2024-02-05 Chengcheng Huang, Dan Luo, Mingliang Sun, Guowei Fang, Mengjuan Wei, Yufei Zhang, Jingwu Wang, Yanqin Huang
Diabetes retinopathy (DR) is a common microvascular complication of diabetes, and it is the main cause of global vision loss. The current observational research results show that the causal relationship between Vitamin D and DR is still controversial. Therefore, we conducted a Mendelian randomization study to determine the potential causal relationship between serum 25-hydroxyvitamin D 25(OH)D and