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Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway Neuromol. Med. (IF 3.5) Pub Date : 2024-04-23 Yingxi He, Yanyou Wang, Xia Li, Yanqiang Qi, Zuwei Qu, Yanli Hu
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The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis Neuromol. Med. (IF 3.5) Pub Date : 2024-04-17 Mohamed J. Saadh, Hani Moslem Ahmed, Zaid Khalid Alani, Rafil Adnan Hussein Al Zuhairi, Zainab M. Almarhoon, Hijaz Ahmad, Mohammed Ubaid, Nathera Hussin Alwan
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Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma Neuromol. Med. (IF 3.5) Pub Date : 2024-04-15 Yuebing Wang, Musukha Mala Brahma, Kazuya Takahashi, Alessandra Nolia Blanco Hernandez, Koki Ichikawa, Syuntaro Minami, Yoshio Goshima, Takayuki Harada, Toshio Ohshima
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Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway Neuromol. Med. (IF 3.5) Pub Date : 2024-04-10 Kun Wang, Zicong Shen, Xin Peng, Xiaotao Wu, Lu Mao
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The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation Neuromol. Med. (IF 3.5) Pub Date : 2024-04-09 María Fernanda Serna-Rodríguez, Oscar Cienfuegos-Jiménez, Ricardo Martín Cerda-Flores, Iván Alberto Marino-Martínez, Mario Alberto Hernández-Ordoñez, José Alfonso Ontiveros-Sánchez de la Barquera, Antonio Alí Pérez-Maya
Suicide is a global public health issue, with a particularly high incidence in individuals suffering from Major Depressive Disorder (MDD). The role of cholesterol in suicide risk remains controversial, prompting investigations into genetic markers that may be implicated. This study examines the association between CYP46A1 polymorphisms, specifically SNPs rs754203 and rs4900442, and suicide risk in
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Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis Neuromol. Med. (IF 3.5) Pub Date : 2024-04-04 Oak Z. Chi, Xia Liu, Harvey Fortus, Guy Werlen, Estela Jacinto, Harvey R. Weiss
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Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation Neuromol. Med. (IF 3.5) Pub Date : 2024-04-03 Baojian Guo, Chengyou Zheng, Jie Cao, Xiaoling Qiu, Fangcheng Luo, Haitao Li, Simon Mingyuan Lee, Xifei Yang, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Yuqiang Wang
Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson’s disease (PD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent enhancement of the expression of the 20S proteasome core particles (20S CPs) and regulatory particles (RPs) increases proteasome activity, which can promote α-syn clearance in PD. Activation of peroxisome proliferator-activated
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Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia Neuromol. Med. (IF 3.5) Pub Date : 2024-03-28 V. V. Guzenko, S. S. Bachurin, V. A. Dzreyan, A. M. Khaitin, Y. N. Kalyuzhnaya, S. V. Demyanenko
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An Emerging Role for Enhancer RNAs in Brain Disorders Neuromol. Med. (IF 3.5) Pub Date : 2024-03-28 Ankit Patel, Ashutosh Dharap
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Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease Neuromol. Med. (IF 3.5) Pub Date : 2024-03-19 Limin Ma, Fengyu Wang, Shuai Chen, Shenghui Wang, Zhenzhen Wang, Mingrong Xia, Yongli Li, Huimin Ma, Junkui Shang, Jiewen Zhang
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MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients Neuromol. Med. (IF 3.5) Pub Date : 2024-03-15 Antonio Musarò, Gabriella Dobrowolny, Chiara Cambieri, Laura Libonati, Federica Moret, Irene Casola, Gaia Laurenzi, Matteo Garibaldi, Maurizio Inghilleri, Marco Ceccanti
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Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats Neuromol. Med. (IF 3.5) Pub Date : 2024-03-08
Abstract Background: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors living with serious neurological sequelae; thus, it has recently attracted a lot of attention in the field of medical study. Purpose: The aim of this study was to determine the effect of naringin supplementation on neurogenesis and brain-derived neurotrophic factor (BDNF)
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Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3k9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model Neuromol. Med. (IF 3.5) Pub Date : 2024-02-26 Mydhili Radhakrishnan, Vincy Vijay, B. Supraja Acharya, Papia Basuthakur, Shashikant Patel, Kalyani Soren, Arvind Kumar, Sumana Chakravarty
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Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging Neuromol. Med. (IF 3.5) Pub Date : 2024-02-23 Roberto Federico Villa, Federica Ferrari, Antonella Gorini
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Amelioration of Astrocyte-Mediated Neuroinflammation by EI-16004 Confers Neuroprotection in an MPTP-induced Parkinson’s Disease Model Neuromol. Med. (IF 3.5) Pub Date : 2024-01-30
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder that results in motor impairment due to dopaminergic neuronal loss. The pathology of PD is closely associated with neuroinflammation, which can be characterized by astrocyte activation. Thus, targeting the inflammatory response in astrocytes might provide a novel therapeutic approach. We conducted a luciferase assay on an in-house chemical
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Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis Neuromol. Med. (IF 3.5) Pub Date : 2023-10-31 Anjali Singh, Sneha Ghildiyal, Prabhaker Mishra, Gajendra Singh, Himanshu Dandu, Alok Kumar
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MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders Neuromol. Med. (IF 3.5) Pub Date : 2023-10-19 Nahla O. Mousa, Ahmed Abdellatif, Nagia Fahmy, Hassan El-Fawal, Ahmed Osman
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Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice Neuromol. Med. (IF 3.5) Pub Date : 2023-10-16 Jing Yin, Chun-Mei Tuo, Kai-Yue Yu, Xiao-Hong Hu, Yan-Ying Fan, Mei-Na Wu
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Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians Neuromol. Med. (IF 3.5) Pub Date : 2023-10-09 Dipanwita Sadhukhan, Arindam Biswas, Smriti Mishra, Koustav Chatterjee, Daytee Maji, Parama Mitra, Priyanka Mukherjee, Gargi Podder, Biman Kanti Ray, Atanu Biswas, Tapas Kumar Banerjee, Subhra Prakash Hui, Ishani Deb
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CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy Neuromol. Med. (IF 3.5) Pub Date : 2023-10-05 Fang Qiu, Yueming Liu, Yang Liu, Zhuyun Zhao, Lile Zhou, Pengfei Chen, Yunbo Du, Yanmei Wang, Huimin Sun, Changchun Zeng, Xiaokang Wang, Yuqiang Liu, Haobo Pan, Changneng Ke
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Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder Neuromol. Med. (IF 3.5) Pub Date : 2023-09-21 Antonio Gennaro Nicotera, Greta Amore, Maria Concetta Saia, Mirella Vinci, Antonino Musumeci, Valeria Chiavetta, Concetta Federico, Giulia Spoto, Salvatore Saccone, Gabriella Di Rosa, Francesco Calì
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Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR Neuromol. Med. (IF 3.5) Pub Date : 2023-09-23 Alice Laschuk Herlinger, Gustavo Lovatto Michaelsen, Marialva Sinigaglia, Lívia Fratini, Gabriela Nogueira Debom, Elizandra Braganhol, Caroline Brunetto de Farias, Algemir Lunardi Brunetto, André Tesainer Brunetto, Mariane da Cunha Jaeger, Rafael Roesler
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Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity Neuromol. Med. (IF 3.5) Pub Date : 2023-09-21 Hua Fan, Yang Yang, Qianqian Bai, Dongmei Wang, Xiaofei Shi, Lele Zhang, Yanhui Yang
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Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions Neuromol. Med. (IF 3.5) Pub Date : 2023-09-21 Lap Jack Wong, Bernice Woon Li Lee, Yi Jing Sng, Luting Poh, Vismitha Rajeev, Sharmelee Selvaraji, Grant R. Drummond, Christopher G. Sobey, Thiruma V. Arumugam, David Y. Fann
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The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease Neuromol. Med. (IF 3.5) Pub Date : 2023-09-12 Yu Liang, Guangshang Zhong, Mingxin Ren, Tingting Sun, Yangyang Li, Ming Ye, Caiyun Ma, Yu Guo, Changqing Liu
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CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis Neuromol. Med. (IF 3.5) Pub Date : 2023-09-14 Xianxin Kang, Yanhui Cao, Guodong Sun, Dongsheng Fei, Kai Kang, Xianglin Meng, Mingyan Zhao
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Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat Neuromol. Med. (IF 3.5) Pub Date : 2023-09-12 Jaisan Islam, Elina KC, Soochong Kim, Moon Young Chung, Ki Seok Park, Hyong Kyu Kim, Young Seok Park
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Identification of a Novel ARSA Gene Mutation Through High-Throughput Molecular Diagnosis Method in Two Girls with Late Infantile Metachromatic Leukodystrophy Neuromol. Med. (IF 3.5) Pub Date : 2023-09-08 Abolfazl Yari, Farzane Vafaeie, Zahra Miri Karam, Mahya Hosseini, Hassan Hashemzade, Maryam Sadat Rahimi, Alireza Ehsanbakhsh, Ebrahim Miri-Moghaddam
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Dysregulated COMT Expression in Fragile X Syndrome Neuromol. Med. (IF 3.5) Pub Date : 2023-09-08 Kagistia Hana Utami, Nur Amirah Binte Muhammed Yusof, Marta Garcia-Miralles, Niels Henning Skotte, Srikanth Nama, Prabha Sampath, Sarah R. Langley, Mahmoud A. Pouladi
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Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions Neuromol. Med. (IF 3.5) Pub Date : 2023-08-30 Lap Jack Wong, Bernice Woon Li Lee, Yi Jing Sng, Luting Poh, Vismitha Rajeev, Sharmelee Selvaraji, Grant R. Drummond, Christopher G. Sobey, Thiruma V. Arumugam, David Y. Fann
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PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance Neuromol. Med. (IF 3.5) Pub Date : 2023-08-23 Bianca Soares Carlotto, Patricia Trevisan, Valentina Oliveira Provenzi, Fabiano Pasqualotto Soares, Rafael Fabiano Machado Rosa, Marileila Varella-Garcia, Paulo Ricardo Gazzola Zen
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A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency Neuromol. Med. (IF 3.5) Pub Date : 2023-08-21 Ying Zhao, Yan Lin, Bin Wang, Fuchen Liu, Dandan Zhao, Wei Wang, Hong Ren, Jiayin Wang, Zhihong Xu, Chuanzhu Yan, Kunqian Ji
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Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA-R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus Neuromol. Med. (IF 3.5) Pub Date : 2023-07-17 Anugya Srivastava, Anima Kumari, Pankaj Jagdale, Anjaneya Ayanur, Aditya Bhushan Pant, Vinay Kumar Khanna
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Targeting Pericytes for Functional Recovery in Ischemic Stroke Neuromol. Med. (IF 3.5) Pub Date : 2023-05-11 Shuqi Hu, Bingjie Yang, Song Shu, Xudong He, Hongfei Sang, Xuemei Fan, Hao Zhang
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Pathophysiological Links Between Obesity and Dementia Neuromol. Med. (IF 3.5) Pub Date : 2023-04-22 David E. Wong Zhang, Vivian Tran, Antony Vinh, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Maria Jelinic, T. Michael De Silva
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Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease? Neuromol. Med. (IF 3.5) Pub Date : 2023-04-07 Benita Wiatrak, Paulina Jawień, Adam Szeląg, Izabela Jęśkowiak-Kossakowska
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Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers Neuromol. Med. (IF 3.5) Pub Date : 2023-04-05 Mina Mohammadinasr, Soheila Montazersaheb, Ommoleila Molavi, Houman Kahroba, Mahnaz Talebi, Hormoz Ayromlou, Mohammad Saeid Hejazi
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Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose Neuromol. Med. (IF 3.5) Pub Date : 2023-04-05 Pinzhong Chen, Xiaohui Chen, Honghong Zhang, Jianghu Chen, Mingxue Lin, Haitao Qian, Fei Gao, Yisheng Chen, Cansheng Gong, Xiaochun Zheng, Ting Zheng
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Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of Individuals with Schizophrenia: Meta-analysis Neuromol. Med. (IF 3.5) Pub Date : 2023-04-02 Anat Shamir, Assif Yitzhaky, Aviv Segev, Vahram Haroutunian, Pavel Katsel, Libi Hertzberg
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Transcriptome Analysis of the Mouse Medial Prefrontal Cortex in a Chronic Constriction Injury Model Neuromol. Med. (IF 3.5) Pub Date : 2023-03-27 Qi-Min Zheng, Zi-Rui Zhou, Xin-Yu Hou, Ning Lv, Yu-Qiu Zhang, Hong Cao
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Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism Neuromol. Med. (IF 3.5) Pub Date : 2023-03-13 Yue Qi, Ziwei Zhang, Yanning Li, Guojian Zhao, Jinyong Huang, Yi Zhang, Jinhua Xue, Xiaolu Tang
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IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE Neuromol. Med. (IF 3.5) Pub Date : 2023-03-01 Julian Zimmermann, Louisa Nitsch, Marius Krauthausen, Marcus Müller
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The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced Microglial M1 Polarization and Inflammation by Regulating Glycolysis Neuromol. Med. (IF 3.5) Pub Date : 2023-02-07 Wei Cao, Zhengzhe Feng, Deyuan Zhu, Suya Li, Meng Du, Shifei Ye, Dayong Qi, Peng Li, Yan Chen, Yibin Fang
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Spautin-1 Protects Against Mild TBI-Induced Anxiety-Like Behavior in Mice via Immunologically Silent Apoptosis Neuromol. Med. (IF 3.5) Pub Date : 2023-02-06 Hui-Tao Miao, Rong-Xin Song, Yue Xin, Lu-Ying Wang, Jin-Meng Lv, Na-Na Liu, Zhi-You Wu, Wei Zhang, Yan Li, Dong-Xue Zhang, Li-Min Zhang
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The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson’s Disease Neuromol. Med. (IF 3.5) Pub Date : 2023-02-05 Kumar Suresh, Michael Mattern, Matthew S. Goldberg, Tauseef R. Butt
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Transient Receptor Potential Mucolipin-1 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing Neuroinflammation and Neuronal Cell Death Neuromol. Med. (IF 3.5) Pub Date : 2023-02-04 Jinzhao Shi, Xiang Li, Jiasheng Ding, Jinrong Lian, Yi Zhong, Haiying Li, Haitao Shen, Wanchun You, Xi’an Fu, Gang Chen
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α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation Neuromol. Med. (IF 3.5) Pub Date : 2023-01-23 Jing Kai Fan, Meng Chen Wang, Hui Min Yang, Jian Nan Zhang, Li Gu, Hong Zhang
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CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis Neuromol. Med. (IF 3.5) Pub Date : 2023-01-14 Shuwen Tan, Hui Gao, Jianyu Sun, Na Li, Yuxin Zhang, Liu Yang, Min Wang, Qiang Wang, Qian Zhai
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Involvement of Microbiome Gut–Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury Neuromol. Med. (IF 3.5) Pub Date : 2022-12-08 Ramya Balasubramanian, Mohd Rabi Bazaz, Tulasi Pasam, Naserunnisa Sharief, Laximan Velip, Gananadhamu Samanthula, Manoj P. Dandekar
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Tau and GSK-3β are Critical Contributors to α-Synuclein-Mediated Post-Stroke Brain Damage Neuromol. Med. (IF 3.5) Pub Date : 2022-11-30 Suresh L. Mehta, TaeHee Kim, Bharath Chelluboina, Raghu Vemuganti
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The Mood Stabilizer Lithium Slows Down Synaptic Vesicle Cycling at Glutamatergic Synapses Neuromol. Med. (IF 3.5) Pub Date : 2022-11-27 Willcyn Tang, Bradley Cory, Kah-Leong Lim, Marc Fivaz
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SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation Neuromol. Med. (IF 3.5) Pub Date : 2022-11-04 Lanlan Zhong, Xingshu Ren, Yuhang Ai, Zhiyong Liu
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Neuroprotective Effects of Carbonic Anhydrase Inhibition and Cyclic Adenosine Monophosphate Activation in Mouse Model of Transient Global Cerebral Ischemia and Reperfusion Neuromol. Med. (IF 3.5) Pub Date : 2022-10-28 Manish Kumar, Komalpreet Kaur, Thakur Gurjeet Singh
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Protective Effect of Ergothioneine Against Stroke in Rodent Models Neuromol. Med. (IF 3.5) Pub Date : 2022-10-19 Wei-Yi Ong, Mei-Han Kao, Wai-Mui Cheung, Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Teng-Nan Lin
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The Promising Epigenetic Regulators for Refractory Epilepsy: An Adventurous Road Ahead Neuromol. Med. (IF 3.5) Pub Date : 2022-09-24 Vemparthan Suvekbala, Haribaskar Ramachandran, Alaguraj Veluchamy, Mariano A. Bruno Mascarenhas, Tharmarajan Ramprasath, M. K. C. Nair, Venkata Naga Srikanth Garikipati, Rohit Gundamaraju, Ramasamy Subbiah
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Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies Neuromol. Med. (IF 3.5) Pub Date : 2022-08-11 Chandra Prakash, Jyoti Tyagi, Shyam Sunder Rabidas, Vijay Kumar, Deepak Sharma
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Induction of ICAM1 in Brain Vessels is Implicated in an Early AD Pathogenesis by Modulating Neprilysin Neuromol. Med. (IF 3.5) Pub Date : 2022-08-10 Degeree Otgongerel, Hyeon-Ju Lee, Sangmee Ahn Jo
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Dimethyl Itaconate Reduces Cognitive Impairment and Neuroinflammation in APPswe/PS1ΔE9 Transgenic Mouse Model of Alzheimer’s Disease Neuromol. Med. (IF 3.5) Pub Date : 2022-08-08 Jing Xiong, Dong-Lin Lu, Bai-Qiang Chen, Tong-Yun Liu, Zi-Xuan Wang
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Protective Effect of Ulinastatin on Cognitive Function After Hypoxia Neuromol. Med. (IF 3.5) Pub Date : 2022-08-02 Young Sung Kim, Sung-Hwa Sohn, Too Jae Min
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Implication of Paraprobiotics in Age-Associated Gut Dysbiosis and Neurodegenerative Diseases Neuromol. Med. (IF 3.5) Pub Date : 2022-07-25 Ziaur Rahman, Manoj P. Dandekar