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Opioid-induced Constipation: Old and New Concepts in Diagnosis and Treatment. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Francesco Squeo, Francesca Celiberto, Enzo Ierardi, Francesco Russo, Giuseppe Riezzo, Benedetta D'Attoma, Alfredo Di Leo, Giuseppe Losurdo
Daily use of opioid analgesics has significantly increased in recent years due to an increasing prevalence of conditions associated with chronic pain. Opioid-induced constipation (OIC) is one of the most common, under-recognized, and under-treated side effects of opioid analgesics. OIC significantly reduces the quality of life by causing psychological distress, lowering work productivity, and increasing
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Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Yu-Xin Zhang, Yan-Jiao Zhang, Min Li, Jia-Xing Tian, Xiao-Lin Tong
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients. Research on
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Retrograde Cricopharyngeus Dysfunction, a New Motility Disorder: Single Center Case Series and Treatment Results. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Stijn Arnaert, Joris Arts, Karlien Raymenants, Filip Baert, Kathelijne Delsupehe
Retrograde cricopharyngeus dysfunction (R-CPD) is a new clinical entity characterized by inability to belch and associated symptoms of loud gurgling noises, chest and/or abdominal pressure, abdominal bloating, and excessive flatulence. R-CPD can be treated with botulinum toxin (BT) injection in the upper esophageal sphincter. We hereby report patient demographics, symptomatology, and treatment results
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The Effects of Fermented Rice Drink With Lactiplantibacillus plantarum JSA22 in Overweight Irritable Bowel Syndrome Patients: A Randomized, Double-blind, Placebo-controlled Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Nam-Hee Kim, Hye Sun Choi, Moon Young Lee, Hyunbin Seong, Nam Soo Han, Hae-Jin Hu, Yong Sung Kim, Jung Ho Park
This study aims to investigate the effect of a fermented rice drink with Lactiplantibacillus plantarum JSA22 on symptoms, blood tests, microbiomes, and fecal metabolites in patients with irritable bowel syndrome (IBS) who were overweight.
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Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Kumi Nakaya, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Satoshi Nagaie, Tomohiro Nakamura, Motoyori Kanazawa, Soichi Ogishima, Nobuo Fuse, Shin Fukudo, Atsushi Hozawa
The objective of this research is to examine factors related to irritable bowel syndrome (IBS) prevalence in a large population-based study.
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Effect of Trimebutine and Rifaximin on Breath Hydrogen and Methane by Glucose Breath Test in Patients With Functional Bloating: A Randomized Double-blind Clinical Trial. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Ik Hyun Jo, Chang-Nyol Paik, Ji Min Lee, Do Seon Song, Yeon-Ji Kim
Drugs that stabilize intestinal motility may improve the efficacy of nonabsorbable antibiotics, such as rifaximin, against small intestinal bacterial overgrowth (SIBO). We compared the efficacy of rifaximin alone with that of its combination with trimebutine maleate against SIBO.
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Multimorbidity of Allergic Diseases Is Associated With Functional Gastrointestinal Disorders in a Young Japanese Population. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Yasunori Yamamoto, Shinya Furukawa, Teruki Miyake, Junichi Watanabe, Yukihiro Nakamura, Yoshihiro Taguchi, Tetsuya Yamamoto, Aki Kato, Katsunori Kusumoto, Osamu Yoshida, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Yuka Saeki, Osamu Yamaguchi, Yoichi Hiasa
Although certain allergic diseases have been reported to be associated with the prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS), it is unclear whether the presence of multiple allergic diseases further increases the prevalence of FD and IBS. The aim of this study is to determine this issue in young people.
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The Effect of Clostridium butyricum on Gut Microbial Changes and Functional Profiles of Metabolism in High-fat Diet-fed Rats Depending on Age and Sex. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-4-5 Soo In Choi, Nayoung Kim, Yonghoon Choi, Ryoung Hee Nam, Jae Young Jang, Sung-Yup Cho
A high-fat diet (HFD) causes dysbiosis and promotes inflammatory responses in the colon. This study aims to evaluate the effects of Clostridium butyricum on HFD-induced gut microbial changes in rats.
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Consistency of Feces Affects Defecatory Function. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-03-27 Daming Sun, Kar Man Lo, Ssu-Chi Chen, Wing Wa Leung, Cherry Wong, Tony Mak, Simon Ng, Kaori Futaba, Hans Gregersen
It is a common belief that constipated patients have hard feces that contributes to the difficulties defecating. To the best of our knowledge, no studies had been published on controlled evacuation of simulated feces with different consistencies.
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Masculinity, Rather Than Biological Sex, Is Associated With Psychological Comorbidities in Patients With Irritable Bowel Syndrome. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-02-07 Yong Sung Kim, Ju Yup Lee, Jung-Wook Kim, Seung Joo Kang, Jung Ho Park, Hyun Jin Kim, Seung-Ho Jang, Ji-Hyeon Kim, Jung-Hwan Oh
Irritable bowel syndrome (IBS) generally shows sex differences, and psychiatric comorbidities play an important role in its pathogenesis. We aim to measure the levels of gender roles and investigate their relationship with psychiatric factors in patients with IBS versus healthy controls.
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Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Will Takakura, Ali Rezaie, William D Chey, Jiajing Wang, Mark Pimentel
We performed a systematic review and meta-analysis evaluating the symptomatic response rate to antibiotics in patients with small intestinal bacterial overgrowth (SIBO). Similarly, we performed a meta-analysis on the symptomatic response to antibiotics in irritable bowel syndrome (IBS) patients with and without SIBO.
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Refractory Gastroesophageal Reflux Disease: Diagnosis and Management. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Trevor A Davis, C Prakash Gyawali
Gastroesophageal reflux disease (GERD) is common, with increasing worldwide disease prevalence and high economic burden. A significant number of patients will remain symptomatic following an empiric proton pump inhibitor (PPI) trial. Persistent symptoms despite PPI therapy are often mislabeled as refractory GERD. For patients with no prior GERD evidence (unproven GERD), testing is performed off antisecretory
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Regulatory T cells Are Increased and Correlate With Mast Cells in Eosinophilic Esophagitis. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Junji Chen, Tadayuki Oshima, Toshihiko Tomita, Hirokazu Fukui, Shinichiro Shinzaki
The incidence of eosinophilic esophagitis (EoE) has been increasing recently. The role of regulatory T cells (Tregs) and correlations with other inflammatory cells in EoE remain unknown. We aim to clarify the role of Tregs and their correlations with inflammatory cells in EoE patients.
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Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Wei-Yi Lei, Tso-Tsai Liu, Wei-Chuan Chang, Chih-Hsun Yi, Jui-Sheng Hung, Ming-Wun Wong, Shu-Wei Liang, Lin Lin, Chien-Lin Chen
This study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective esophageal motility (IEM).
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Interpretation of Impedance Data on High-resolution Impedance Manometry Studies-A Worldwide Survey. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Lev Dorfman, Sherief Mansi, Khalil El-Chammas, Chunyan Liu, Ajay Kaul
Esophageal manometry is the gold standard for esophageal motility evaluation. High-resolution esophageal manometry with impedance (HRIM) allows concurrent assessment of bolus transit and manometry. Inconsistencies between concomitant impedance and manometry data pose a clinical dilemma and has not yet been addressed. We aim to assess interpretation trends of HRIM data among gastroenterologists worldwide
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The Disease Spectrum and Natural History of Patients With Abdominal Bloating or Distension: A Longitudinal Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Fangfei Chen, Niandi Tan, Songfeng Chen, Qianjun Zhuang, Mengyu Zhang, Yinglian Xiao
Abdominal bloating or distension (AB/D) is a common complaint in the outpatient of gastroenterology department. Since the potential contributors are numerous and complex, a longitudinal study on the disease spectrum and natural history of patients was performed to better understand the key factors of AB/D.
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Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Young Hoon Chang, Yoon Jin Choi, Cheol Min Shin, Jin Seok Moon, Tae-Yoon Kim, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
To evaluate the efficacy of quadruple-coated probiotics (gQlab) in patients with irritable bowel syndrome (IBS), focusing on sex differences and IBS subtypes.
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Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 David Deutsch, Michel Bouchoucha, Julien Uzan, Gheorghe Airinei, Jean-Marc Sabate, Robert Benamouzig
Eating is the major synchronizer of gastrointestinal motility and secretions. The present study aims to evaluate the interplay between self-perceived constipation severity (CS) and colonic response to eating in constipated patients according to the phenotype.
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Clinical Trial: Efficacy of Mosapride Controlled-release and Nortriptyline in Patients With Functional Dyspepsia: A Multicenter, Double-placebo, Double-blinded, Randomized Controlled, Parallel Clinical Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2024-1-4 Chung Hyun Tae, Ra Ri Cha, Jung-Hwan Oh, Tae-Guen Gweon, Jong Kyu Park, Ki Bae Bang, Kyung Ho Song, Cheal Wung Huh, Ju Yup Lee, Cheol Min Shin, Jong Wook Kim, Young Hoon Youn, Joong Goo Kwon
Prokinetic agents and neuromodulators are among the treatment options for functional dyspepsia (FD), but their comparative efficacy is unclear. We aimed to compare the efficacy of mosapride controlled-release (CR) and nortriptyline in patients with FD after 4 weeks of treatment.
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Esophageal Motility Abnormalities in Lung Transplant Recipients With Esophageal Acid Reflux Are Different From Matched Controls. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-12-08 Mazen Elsheikh, Lekan Akanbi, Lisbeth Selby, Bahaaeldeen Ismail
There is an increased incidence of gastroesophageal reflux disease (GERD) after lung transplantation (LT) that can be associated with graft dysfunction. It is unclear if the underlying esophageal motility changes in GERD are different following LT. This study aimed to use esophageal high-resolution manometry (HRM) to explore GERD mechanisms in LT recipients compared to matched controls.
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The Prevalence and Characteristics of Symptomatic Uncomplicated Diverticular Disease Among Asian Patients With Unexplained Abdominal Symptoms. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-11-28 Tsumugi Jono,Yuki Kasai,Takaomi Kessoku,Tomoki Ogata,Kosuke Tanaka,Tsutomu Yoshihara,Noboru Misawa,Shingo Kato,Takuma Higurashi,Kunihiro Hosono,Masato Yoneda,Kosuke Seita,Takayuki Kato,Eiji Sakai,Takeo Kurihashi,Machiko Nakatogawa,Shunsuke Oyamada,Seiji Futagami,Kok-Ann Gwee,Atsushi Nakajima
Background/Aims The precise incidence of symptomatic uncomplicated diverticular disease (SUDD) and its effects on the quality of life (QOL) remain unclear, particularly in Asian patients with right-sided SUDD. We assess the prevalence of SUDD and its impact on QOL in a real-world population. Methods Five institutional cohorts of patients who received outpatient treatment for unexplained abdominal symptoms
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Roles of Cytokines in Pathological and Physiological Gastroesophageal Reflux Exposure. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-11-14 Pelin Ergun,Sezgi Kipcak,Nur S Gunel,Serhat Bor,Eser Y Sozmen
Background/Aims Gastroesophageal reflux disease is frequently observed and has no definitive treatment. There are 2 main views on the pathogenesis of gastroesophageal reflux disease. The first is that epithelial damage starts from the mucosa by acidic-peptic damage and the inflammatory response of granulocytes. The other view is that T-lymphocytes attract chemoattractants from the basal layer to the
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Spot Hydrogen Breath Test: A Great Hockey Player Plays Where the Puck Is Going to Be. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-30 Tae Hee Lee
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Deciphering the Immune Complexity of Esophageal Achalasia. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-30 Hyunsoo Chung
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The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Ayesheh Enayati, Aida Soghi, Alexandra E Butler, Manfredi Rizzo, Amirhossein Sahebkar
The gut-brain axis describes the bidirectional communication between the gut, the enteric nervous system, and the central nervous system. The gut-brain axis has attracted increasing attention owing to its regulatory effect on dysbiosis and a wide range of related diseases. Several types of nutrients, such as curcumin, have been proposed as regulators of the dysbiotic state, and preclinical experiments
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Modern Achalasia: Diagnosis, Classification, and Treatment. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Marcella Pesce, Marta Pagliaro, Giovanni Sarnelli, Rami Sweis
Achalasia is a major esophageal motor disorder featured by the altered relaxation of the esophagogastric junction in the absence of effective peristaltic activity. As a consequence of the esophageal outflow obstruction, achalasia patients present with clinical symptoms of dysphagia, chest pain, weight loss, and regurgitation of indigested food. Other less specific symptoms can also present including
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Constipation in Patients With Chronic Kidney Disease. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Ra Ri Cha, Seon-Young Park, Michael Camilleri
Constipation is a frequent symptom in patients with chronic kidney disease (CKD). This review outlines the mechanisms and management of constipation in patients with CKD from a physician's perspective. Common causes of constipation in patients with CKD include concomitant medications, low dietary fiber intake, water-restricted diet, lack of physical activity, altered gut microbiota, and reduced gastrointestinal
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Revisiting the Role of Esophageal Mucosal Dilated Intercellular Spaces in the Diagnosis and Pathophysiology of Heartburn. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Volkan Gorgulu, Pelin Ergun, Sezgi Kipcak, Basak Doganavsargil, Daniel Sifrim, Serhat Bor
Dilated intercellular spaces (DISs) facilitate the diffusion of noxious agents into the deep layers of the esophageal epithelium. The role of DIS in heartburn pathogenesis is still controversial. Therefore, we aim to reinvestigate DIS in an extensively evaluated group of patients and healthy controls (HCs).
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Non-cardiac Chest Pain in Japan: Prevalence, Impact, and Consultation Behavior - A Population-based Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Junji Chen, Tadayuki Oshima, Takashi Kondo, Toshihiko Tomita, Hirokazu Fukui, Shinichiro Shinzaki, Hiroto Miwa
Non-cardiac chest pain (NCCP) is defined as recurring angina-like retrosternal chest pain of non-cardiac origin. Information about the epidemiology of NCCP in Japan is lacking. We aim to determine the prevalence and characteristics of NCCP in the Japanese general population.
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On-demand Versus Continuous Maintenance Treatment With a Proton Pump Inhibitor for Mild Gastroesophageal Reflux Disease: A Prospective Randomized Multicenter Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Da Hyun Jung, Young Hoon Youn, Hye-Kyung Jung, Seung Young Kim, Cheal Wung Huh, Cheol Min Shin, Jung-Hwan Oh, Kyu Chan Huh, Moo In Park, Suck Chei Choi, Ki Bae Kim, Seon-Young Park, Joong Goo Kwon, Yu Kyung Cho, Jung Ho Park, Jeong Eun Shin, Eun Jeong Gong, Jae Hak Kim, Su Jin Hong, Hyun Jin Kim, Sam Ryong Jee, Ju Yup Lee, Kee Wook Jung, Hee Man Kim, Kwang Jae Lee
It remains unclear which maintenance treatment modality is most appropriate for mild gastroesophageal reflux disease (GERD). We aimed to compare on-demand treatment with continuous treatment using a proton pump inhibitor (PPI) in the maintenance treatment for patients with non-erosive GERD or mild erosive esophagitis.
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Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational, Cross-sectional, Multicenter Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Cheal Wung Huh, Nak Hoon Son, Young Hoon Youn, Da Hyun Jung, Min Kyung Kim, Eun Jeong Gong, Kyu Chan Huh, Seung Young Kim, Moo In Park, Ju Yup Lee, Joong Goo Kwon, Jae Hak Kim, Cheol Min Shin, Kee Wook Jung, Su Jin Hong, Hee Man Kim, Suck Chei Choi, Hye-Kyung Jung, Hyun Jin Kim, Kwang Jae Lee
Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD.
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Spot Hydrogen Breath Test for Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Dietary Advice in Patients With Bloating. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Pochara Somvanapanich, Panyavee Pitisuttithum, Jarongkorn Sirimongkolkasem, Pakkapon Rattanachaisit, Sureeporn Jangsirikul, Tanisa Patcharatrakul, Sutep Gonlachanvit
An increase in postprandial intestinal gas plays a role in bloating symptoms. We aim to study the utility of spot breath hydrogen (H2) level in predicting the response to a low fermentable oligo-, di-, mono-saccharides, and polyols (FODMAPs) diet.
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Distinct Effects of Non-absorbed Agents Rifaximin and Berberine on the Microbiota-Gut-Brain Axis in Dysbiosis-induced Visceral Hypersensitivity in Rats. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-10-10 Jindong Zhang, Cunzheng Zhang, Tao Zhang, Lu Zhang, Liping Duan
Irritable bowel syndrome (IBS) is accepted as a disorder of gut-brain interactions. Berberine and rifaximin are non-absorbed antibiotics and have been confirmed effective for IBS treatment, but there is still lack of direct comparison of their effects. This study aims to compare the effect of the 2 drugs on the alteration of gut-brain axis caused by gut microbiota from IBS patients.
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Characteristics and risk factors of Functional Dyspepsia fulfilling the Rome IV Criteria overlapping with Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-09-27 Yan-Qin Long,Wen-Li Xu,Lu-Xiu Li,Hui-Qin He,Jing-Jie Wang,Guo-Dong Shan,Ning Dai,Hong-Tan Chen
Background/Aims Functional dyspepsia (FD) overlapping with other gastrointestinal disorders are quite common. The characteristics of FD overlap in Chinese population with latest Rome IV criteria were unclear. This large-scale outpatient-based study assessed the characteristics of FD overlap in South China. Methods Consecutive FD patients visited the Gastroenterology Clinic at 2 tertiary medical centers
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Achalasia and Hiatal Hernia: A Rare Association and a Therapeutic Challenge. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-08-27 Georgiana Tutuian,Chloé Leandri,Radu Tutuian,Sophie Scialom,Mahaut Leconte,Anthony Dohan,Romain Coriat,Stanislas Chaussade,Maximilien Barret
Background/Aims Achalasia and hiatal hernia are rarely associated. The aim of the current study is to explore the clinical and manometric findings in patients with achalasia and hiatal hernia, and to determine if the presence of a hiatal hernia should influence therapeutic management in patients with achalasia. Methods This retrospective single center analysis included a group of patients with achalasia
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A Higher Manometric Esophageal Length to Height Ratio in Achalasia Explains the Lower Prevalence of Hiatal Hernia. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-08-24 Enrique Coss-Adame, Janette Furuzawa-Carballeda, Andric C Perez-Ortiz, Ana López-Ruiz, Miguel A Valdovinos, Josué Sánchez-Gómez, José Peralta-Figueroa, Héctor Olvera-Prado, Fidel López-Verdugo, Sofía Narváez-Chávez, Ó Scar Santés-Jasso, Diana Aguilar-León, Gonzalo Torres-Villalobos
The evidence suggests that a shorter esophageal length (EL) in gastroesophageal reflux (GERD) patients is associated with the presence of hiatal hernia (HH). However, there are no reports of this association in patients with achalasia. The aim is to (1) determine the prevalence of hiatal hernia in achalasia patients, (2) compare achalasia EL with GERD patients and healthy volunteers (HV), (3) measure
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Imbalance of Innate and Adaptive Immunity in Esophageal Achalasia. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-08-16 Lu Yao,Zuqiang Liu,Weifeng Chen,Jiaqi Xu,Xiaoyue Xu,Jiaxin Xu,Liyun Ma,Xiaoqing Li,Quanlin Li,Pinghong Zhou
Background/Aims Previous studies reveal that immune-mediated neuroinflammation plays a key role in the etiology of esophageal achalasia. However, the understanding of leucocyte phenotype and proportion is limited. This study aim to evaluate the phenotypes of leukocytes and peripheral blood mononuclear cells transcriptomes in esophageal achalasia. Methods We performed high-dimensional flow cytometry
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Multiple Sclerosis Is Associated With Achalasia and Diffuse Esophageal Spasm. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-08-02 Yeseong Kim,Fahmi Shibli,Yuhan Fu,Gengqing Song,Ronnie Fass
Background/Aims Multiple sclerosis (MS) is an inflammatory disease characterized by the demyelination of primarily the central nervous system. Diffuse esophageal spasm (DES) and achalasia are both disorders of esophageal peristalsis which cause clinical symptoms of dysphagia. Mechanisms involving dysfunction of the pre- and post-ganglionic nerve fibers of the myenteric plexus have been proposed. We
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Altered Esophageal Smooth Muscle Phenotype in Achalasia. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-08-02 David M Rodrigues,Sandra R Lourenssen,Jay Kataria,William G Paterson,Michael G Blennerhassett,Robert Bechara
Background/Aims Achalasia is a disorder characterized by impairment in lower esophageal sphincter relaxation and esophageal aperistalsis, caused primarily by loss of inhibitory innervation. However, little is known about associated changes in esophageal smooth muscle. We examined the contractile phenotype and innervation of the circular smooth muscle, as well as inflammatory status, and correlated
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Autonomic Dysfunction and Somatization in Young Patients With Irritable Bowel Syndrome and Mitral Valve Prolapse Syndrome. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-07-30 Jannis Kountouras,Apostolis Papaefthymiou,Stergios A Polyzos,Elisabeth Vardaka,Foteini Kyrailidi,Maria C Mouratidou,Christos Zavos,Evangelos Kazakos,Dimitrios Chatzopoulos,Maria Tzitiridou-Chatzopoulou,Dimitrios Tzilves,Christos Liatsos,Maria Touloumtzi,Michael Doulberis
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Do Proton Pump Inhibitor-refractory Laryngeal Symptoms Represent a True Acid-related Disease? J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-07-30 Kwon-Eui Hong,Cheal Wung Huh
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The Use of Intraoperative Esophageal Functional Luminal Imaging Probe for Prediction of Therapeutic Outcomes in Achalasia Patients. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-07-30 Meng Xia,Yu-Lin Chen,Jianlin Lv
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2022 Seoul Consensus on Clinical Practice Guidelines for Functional Constipation. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Young Sin Cho, Yoo Jin Lee, Jeong Eun Shin, Hye-Kyung Jung, Seon-Young Park, Seung Joo Kang, Kyung Ho Song, Jung-Wook Kim, Hyun Chul Lim, Hee Sun Park, Seong-Jung Kim, Ra Ri Cha, Ki Bae Bang, Chang Seok Bang, Sung Kyun Yim, Seung-Bum Ryoo, Bong Hyeon Kye, Woong Bae Ji, Miyoung Choi, In-Kyung Sung, Suck Chei Choi
Chronic constipation is one of the most common digestive diseases encountered in clinical practice. Constipation manifests as a variety of symptoms, such as infrequent bowel movements, hard stools, feeling of incomplete evacuation, straining at defecation, a sense of anorectal blockage during defecation, and use of digital maneuvers to assist defecation. During the diagnosis of chronic constipation
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Proton Pump Inhibitor-unresponsive Laryngeal Symptoms Are Associated With Psychological Comorbidities and Sleep Disturbance: A Manometry and Impedance-pH Monitoring Study Wen. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Wen-Hsuan Tseng, Wei-Chung Hsu, Tsung-Lin Yang, Tzu-Yu Hsiao, Jia-Feng Wu, Hui-Chuan Lee, Hsiu-Po Wang, Ming-Shiang Wu, Ping-Huei Tseng
Laryngeal symptoms are largely treated with empiric proton pump inhibitor (PPI) therapy if no apparent pathology shown on ear, nose, and throat evaluation and reflux-related etiologies are suspected. However, treatment response remains unsatisfactory. This study aimed to investigate the clinical and physiological characteristics of patients with PPI-refractory laryngeal symptoms.
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Comparison of Diagnosis of Esophageal Motility Disorders by Chicago Classification Versions 3.0 and 4.0. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Jin Hee Noh, Kee Wook Jung, In Ja Yoon, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
We aim to investigate the diagnostic accuracy and differences between Chicago classification version 3.0 (CC v3.0) and 4.0 (CC v4.0).
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Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Sebastian S Zeki, Ismail Miah, Pierfrancesco Visaggi, Anna Wolak, Minerva deSilva, Jason M Dunn, Andrew Davies, James Gossage, Abrie Botha, Guiping Sui, Jafar Jafari, Terry Wong
Extended wireless pH monitoring (WPM) is used to investigate gastroesophageal reflux disease (GERD) as subsequent or alternative investigation to 24-hour catheter-based studies. However, false negative catheter studies may occur in patients with intermittent reflux or due to catheter-induced discomfort or altered behavior. We aim to investigate the diagnostic yield of WPM after a negative 24-hour multichannel
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Gastroesophageal Reflux Characteristics in Supragastric Belching Patients With Positive Versus Negative pH Monitoring: An Evidence of Secondary Gastroesophageal Reflux Disease From Excessive Belching. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Suriya Keeratichananont, Tanisa Patcharatrakul, Sutep Gonlachanvit
A high prevalence of GERD has been reported in patients with supragastric belching. We aim to evaluate reflux characteristics and explore the temporal relationship between supragastric belches (SGBs) and reflux episodes in GERD patients with excessive belching.
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Effect of Helicobacter pylori Eradication on Body Weight: A Multicenter Propensity Score-matched Analysis in Korea. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Jong Wook Kim, Myong Ki Baeg, Chang Seok Bang, Jong-Kyu Park, Jung-Hwan Oh, The Diet
There is growing interest in whether Helicobacter pylori eradication (HPE) can affect body weight.
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Stigma and Efficacy of Zhizhu Kuanzhong Capsules Versus Doxepin in the Treatment of Refractory Functional Dyspepsia: A Randomized Controlled Trial. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Qian-Qian Wang, Li Cheng, Bi-Yu Wu, Hong-Yi Qiu, Ping Xu, Bo Wang, Xiu-Juan Yan, Sheng-Liang Chen
Stigma related with antidepressants is prevalent in patients with functional dyspepsia. It affects medication compliance and efficacy. Herbal medicine acquired a deep-rooted cultural identity in relieving dyspeptic symptoms in Asians. The research was designed to compare the effectiveness of Zhizhu Kuanzhong capsules (ZZKZ) versus doxepin hydrochloride (doxepin) on alleviating stigma and medication
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Ethnic Differences in Anorectal Manometry Findings in Patients With Fecal Incontinence: Results From a Multiethnic Cohort According to the London Classification. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Daniel L Cohen, Amir Mari, Anton Bermont, Dana Zelnik Yovel, Vered Richter, Haim Shirin
Clinical rates of fecal incontinence (FI) are known to vary based on race and ethnicity. It is unclear if anorectal manometry (ARM) findings in patients with FI differ based on ethnicity.
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Natural History of Chronic Intestinal Pseudo-obstruction and Need for Palliative Care. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Kosuke Tanaka, Hidenori Ohkubo, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Noboru Misawa, Akiko Fuyuki, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Takeo Kurihashi, Masataka Taguri, Atsushi Nakajima, Kok-Ann Gwee, Takaomi Kessoku
Natural history of chronic intestinal pseudo-obstruction (CIPO), a rare disease characterized by episodes of non-mechanical obstruction, is unclear in adults. This study evaluates the clinical course of CIPO and palliative care needs of patients.
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An Optogenetics-based Approach to Regulate Colonic Contractions by Modulating the Activity of the Interstitial Cells of Cajal in Mice. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-7-7 Song Zhao, Weidong Tong
The interstitial cells of Cajal (ICC) are pacemaker cells in the gastrointestinal (GI) tract. We examined whether the activity of ICC could be stimulated to control colonic contractions. An optogenetics-based mouse model in which the light-sensitive protein channelrhodopsin-2 (ChR2) was expressed was used to accomplish cell specific, direct stimulation of ICC.
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Randomized Controlled Trial of Anti-reflux Mucosectomy Versus Radiofrequency Energy Delivery for Proton Pump Inhibitor-refractory Gastroesophageal Reflux Disease. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-06-19 Yan Wang,Meihui Lv,Lin Lin,Liuqin Jiang
Background/Aims The efficacy and safety of anti-reflux mucosectomy (ARMS) or radiofrequency energy delivery in the treatment of gastroesophageal reflux disease (GERD) have been reported, but the difference between the 2 remains unclear. Methods This was a single center, randomized, comparative clinical study. Patients with symptoms of heartburn and/or regurgitation despite proton pump inhibitor treatment
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Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-04-30 Daphne Foong,Meena Mikhael,Jerry Zhou,Ali Zarrouk,Xiaodong Liu,Jan Schröder,Jose M Polo,Vincent Ho,Michael D O'Connor
Background/Aims Interstitial cells of Cajal (ICC) are specialized gastrointestinal (GI) pacemaker cells required for normal GI motility. Dysfunctions in ICC have been reported in patients with GI motility disorders, such as gastroparesis, who exhibit debilitating symptoms and greatly reduced quality of life. While the proteins, calcium-activated chloride channel anoctamin-1 (ANO1) and the receptor
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Duodenojejunal Manometric Abnormalities in a Patient With Mesenterium Commune. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-04-30 Gabrio Bassotti,Roberto Cirocchi
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Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-04-30 Ni-Na Song,Xu Huang,Hong-Li Lu,Chen Lu,Jie Chen,Wen-Xie Xu
Background/Aims The gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients' life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this symptom. As a part of the smooth muscle cells, interstitial cells of Cajal, and platelet-derived growth factor receptor alpha-positive (PDGFRα+) cells syncytium
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Intracolonic Administration of Mosapride Citrate Significantly Increases Colonic Motility Compared With Oral Administration. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-04-30 Moon Young Lee,Min Seob Kim,Yong Sung Kim
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Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-04-30 Annie Tremblay,Jeremie Auger,Zainab Alyousif,Sara E Caballero Calero,Olivier Mathieu,Daniela Rivero-Mendoza,Amal Elmaoui,Wendy J Dahl,Thomas A Tompkins
Background/Aims Motility, stool characteristics, and microbiota composition are expected to modulate probiotics' passage through the gut but their effects on persistence after intake cessation remain uncharacterized. This pilot, open-label study aims at characterizing probiotic fecal detection parameters (onset, persistence, and duration) and their relationship with whole gut transit time (WGTT). Correlations
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Prevalence of Irritable Bowel Syndrome in Japan, China, and South Korea: An International Cross-sectional Study. J. Neurogastroenterol. Motil. (IF 3.4) Pub Date : 2023-04-30 Atsushi Takeoka,Takuya Kimura,Shintaro Hara,Toyohiro Hamaguchi,Shin Fukudo,Jun Tayama
Background/Aims Symptoms of irritable bowel syndrome (IBS), a common gut-brain interaction disorder, deteriorate patients' quality of life and increase medical needs; therefore, IBS represents a significant global burden. The estimated global prevalence is approximately 10%; however, accumulated evidence shows international heterogeneity. In this study, we have described and compared the prevalence