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Unusual presentation of PD-1 inhibitors in people living with HIV with advanced gastric cancer: Case report Int. J. STD AIDS (IF 1.4) Pub Date : 2024-04-22 Zhidi Gao, Guangyong XU, Su Wang, Na Guo, Yang YU, Xiaoni Wang
This paper seeks to determine the effect of combination anti-PD-1 and antiretroviral therapy (ART) on people living with HIV (PLWH) with advanced gastric cancer. In our case, a PLWH with recurrent locally advanced gastric cancer was treated with anti-PD-1 inhibitor and ART. A significant reduction in tumor lesions (as demonstrated by contrast-enhanced CT imaging) and a better quality of life were achieved
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‘Monkeypox 2.0’: Case series on a reconditioned virus causing sexually transmissible disease in urban population Int. J. STD AIDS (IF 1.4) Pub Date : 2024-04-13 Jaheersha Pakran, Amal Mohammed Alsaberi, Amani AlFalasi, Tarek Mohamed Karam Husein Ibrahim, Amel Abdalla Eisa Fadl Alnuaimi, Srikumar Goturu, Muneer Mohamed, Reena Mary Abraham, Vidya Lakshmi Sundaramurthi, Aneesh Kunnath Parambath, Beena Jose, Divya Kamat, Thencheri Cheriath Satish, Juwariya Tasneem Syeda, Lubna Gul, Rohini Mathias, Sajeela Rasheed Vattiyamveetil, Shaheela Backar, C Vijay Krishna
BackgroundMPOX (Monkeypox) viral infection, a zoonotic disease previously confined to the African sub-continent, has caught attention worldwide recently due to its resurgence in a new ‘avatar’ among urban communities. Dermatologists in the U. A. E. started to see patients with fever and a self-limiting pustular necrotic rash that was negative for all other infectious investigations.MethodsWe performed
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Oral streptococcal susceptibility to azithromycin may be associated with doxycycline use: A post-hoc analysis with implications for doxycycline post exposure prophylaxis Int. J. STD AIDS (IF 1.4) Pub Date : 2024-04-12 Thibaut Vanbaelen, Irith De Baetselier, Sheeba Santhini Manoharan-Basil, Chris Kenyon
ObjectiveTetracycline and macrolide resistance are frequently linked in streptococci and other species. We aimed to assess the association between doxycycline use and azithromycin MICs in oral streptococci.MethodsLinear regression was used to assess the association between doxycycline use in the prior year and the median MIC per participant of oral streptococcal colonies isolated at the baseline visit
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Nebulised pentamidine prophylaxis of pneumocystis pneumonia in adults accessing HIV services at royal free hospital, London Int. J. STD AIDS (IF 1.4) Pub Date : 2024-04-12 Malin Bergstrom, Anika Rahim, Jane Akodu, Gavin Marshall, Cora Harrison, Louisa Penrose, Marc CI Lipman, Robert F Miller
Receipt of nebulised pentamidine in people with HIV was audited to identify if individuals were appropriately receiving nebulised pentamidine, and whether national guidelines were being followed when prophylaxis was commenced and discontinued. Of 76 people with who received nebulised pentamidine, the main indication for starting nebulised pentamidine was a co-trimoxazole adverse drug reaction. Co-trimoxazole
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Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study Int. J. STD AIDS (IF 1.4) Pub Date : 2024-04-12 Daniel Augusto Barnabé Nobre, Mariela Dutra Gontijo Moura, José Alcides Almeida de Arruda, Fernanda Aragão Felix, Priscilla Barbosa Diniz, Eliza Carla Barroso Duarte, Lucas Guimarães Abreu, Ricardo Santiago Gomez, Ricardo Alves Mesquita
BackgroundThis study evaluated the presence of Epstein-Barr virus type 1 (EBV-1) DNA in patients living with HIV, before and after three different topical therapy protocols for oral hairy leukoplakia (OHL).MethodsThe sample consisted of five patients treated with topical solution of 25% podophyllin resin; six with 25% podophyllin resin plus 5% acyclovir cream; and four with 25% podophyllin resin plus
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HPV-associated oropharyngeal carcinomas in patients living with HIV on long-term antiretroviral therapy: Case reports Int. J. STD AIDS (IF 1.4) Pub Date : 2024-04-12 Nina Yancheva-Petrova, Rusina Grozdeva, Daniel Ivanov, Dimitar Strashimirov
In the 1970s, human papillomaviruses (HPV) were ascertained as the aetiologic agents of cervical carcinoma. Subsequently, an association with HPV was established in other epithelial tumours, including squamous cell carcinoma of the head and neck (HNSCC). HPV has demonstrated a high potential for inducing oropharyngeal tumours, with HPV-16 infection posing a significant oncogenic risk. People living
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Breaking barriers: Assessing pre-exposure prophylaxis awareness and willingness to use in the Lebanese community Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-28 Akel Azzi, Carine Chartouni, Racha Ibrahim, Zeina Bou Chebel, Elie Haddad, Nabil Chehata, Jacques Choucair, Gebrael Saliba
BackgroundIn the evolving HIV landscape, the Middle East and Northern Africa (MENA) grapples with data gaps, hindering the 95–95–95 targets. Lebanon, despite progress, falls short. Our study addresses Pre-exposure Prophylaxis (PrEP) gaps for effective HIV prevention.MethodsSurveying 410 participants via snowball sampling and an online questionnaire, we analyzed data with chi-square and regression over
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Homocysteine modifies the association of coronary stenosis and HIV infection in an inner city African American population Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-27 Thorsten M Leucker, Tarek Harb, Gary Gerstenblith, David D Celentano, Efthymios Ziogos, Glenn Treisman, Raul N Mandler, Jag Khalsa, Man Charurat, Shenghan Lai, Hong Lai
Background and aimsPeople with HIV (PWH) whose disease is controlled on anti-retroviral regimens remain at an increased risk for coronary artery disease (CAD). Traditional cardiovascular risk factors do not fully explain the residual risk in PWH suggesting contributions from nontraditional factors. Homocysteine (Hcy) may be one of these as prior work in adults without HIV demonstrate that Hcy may impair
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Scratching beneath the surface: An evaluation of the management of scabies 2017–2023 Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-27 Bryony Broster, Amanda Clarke, Collins Iwuji, Suneeta Soni
IntroductionPossible resistance to recommended treatments for scabies has emerged recently. In response to anecdotal reports of a recent increase in treatment failure with permethrin, the British Association for Sexual Health and HIV (BASHH) released a statement alerting members to this.AimsTo examine attendances and the treatment pathways for scabies cases seen at local sexual health clinics.MethodologyA
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Losing sight of CMV retinitis: An emerging cause of blindness among the youth living with HIV in the Philippines Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-27 Patrick C Eustaquio, Corrina P Azarcon, J Carlo M Artiaga
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Tuberculosis preventive treatment uptake among adults living with human immunodeficiency virus: Analysis of Zimbabwe population-based human immunodeficiency virus impact assessment 2020 Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-22 Talent Maphosa, Kelsey Mirkovic, Rachel A. Weber, Godfrey Musuka, Munyaradzi P. Mapingure, Julia Ershova, Rebecca Laws, Trudy Dobbs, William Coggin, Charles Sandy, Tsitsi Apollo, Owen Mugurungi, Michael Melchior, Mansoor S. Farahani
BackgroundTuberculosis remains the leading cause of death by an infectious disease among people living with HIV (PLHIV). TB Preventive Treatment (TPT) is a cost-effective intervention known to reduce morbidity and mortality. We used data from ZIMPHIA 2020 to assess TPT uptake and factors associated with its use.MethodologyZIMPHIA a cross-sectional household survey, estimated HIV treatment outcomes
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Penile median raphe gonococcal infection Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-20 Blanca Santos-Latasa, Francisco-Javier Bru-Gorraiz, Alejandro Martin-Gorgojo
The occurrence of cysts and papulopustules along the midline penile raphe, as a complication of gonococcal urethritis, is considered an exceptional presentation. These lesions are related to developmental abnormalities in the fusion of the lower portion of the ventral abdominal wall during embryogenesis, which create small pathways along the raphe of the penis, prone to secondary infection in the presence
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Differences in socio-demographics status, risk behaviours, healthcare uptake and HIV/ sexually transmitted infections (STIs) between brothel-based and street-based female sex workers in Yunnan, China Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-20 Guoxi Cai, Yufen Liu, Jinman Zhuang, Zishan Chen, Yixiao Lu, Jiwen Wu, Zhijian Hu, Jianping Zhang, Fei He
BackgroundHeterosexual contact is the primary mode of HIV transmission in China and commercial sex is thought to play a crucial role in China’s epidemic. Female sex workers (FSWs) in China tend to be either brothel-based (BSWs) or street-based (SSWs), but few studies have investigated the differences between these important segments of this difficult-to-reach, high-risk population. Our aim was to explore
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Effect of mass treatment on the long-term prevalence of gonorrhoea, chlamydia and syphilis-a systematic review Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-20 Thibaut Vanbaelen, Sheeba S Manoharan-Basil, Chris Kenyon
BackgroundSelective mass treatment of STIs may lead to a durable reduction in the prevalence of STIs or a temporary reduction associated with an increased probability of antimicrobial resistance emerging.MethodsWe searched PubMed and Google Scholar for studies evaluating the impact of mass STI treatment on the long-term prevalence of chlamydia, gonorrhoea, syphilis and chancroid. The primary outcomes
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Brincidofovir for disease progression due to suspected tecovirimat resistance in association with advanced HIV Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-19 Iris Harrison, Kathryn DeSear, Barbara A Santevecchi, Veena Venugopalan, Kartikeya Cherabuddi, Nicole Iovine, Nila Radhakrishnan
A man with advanced HIV presented with verrucous plaques 2-3 months after initial mpox infection. He received two courses of tecovirimat without resolution of initial mpox lesions and development of new lesions raising concern for resistance. He was treated with two doses of brincidofovir and demonstrated improvement 6 months later.
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Understanding the impact of women’s correct risk perception on human immunodeficiency virus diagnosis: Insights from South Africa Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-16 Handan Wand, Jayajothi Moodley, Tarylee Reddy, Sarita Naidoo
BackgroundSouth African women have the highest burden of HIV infections globally. We investigated the temporal trends and the impact of key factors associated with HIV diagnosis among a nationally representative cohort of South African women.MethodsTotal of 24,657 women who participated in the National HIV, Behaviour and Health Surveys conducted from 2002-to-2017.ResultsDespite decades-long prevention
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New small outbreak of Mpox in Italy: A single-centre case series Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-16 Luca Valtellini, Stefano Ramoni, Susanna Benardon, Francesco Rogari, Andrea Licandro, Carlo G. Carrera, Angelo V. Marzano
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Treponema Pallidum rapid syphilis compared diagnostic algorithm syphilis in men who have sex with men (MSM) Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-13 Putri L Karim, Inda A Aryani, Suroso A Nugroho, Irsan Saleh, Lisa Dewi, Yuli Kurniawati, Fitriani Fitriani
BackgroundSyphilis infection can be asymptomatic and difficult to diagnose based on clinical symptoms. Early detection and treatment are critical for preventing and controlling syphilis as well as long-term serious complications. A serological examination based on the diagnostic algorithm was used to confirm the diagnosis of syphilis. Syphilis is frequent in high-risk groups, such as men who have sex
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Giant inflamed fibroepithelial scrotal polyp mimicking an anogenital wart Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-08 Izuchukwu Ezeh, Andrew Tomkins
We report the case of a young man who has never had any sexual contact presenting with a large scrotal lump with secondary bacterial infection. He reported no prior warts – genital or cutaneous. On examination, he had a large pink cauliform mass on the scrotum with four smaller but similar satellite lesions. Appearances were thought to be consistent with giant condyloma of Buschke and Lowenstein. Once
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British association for sexual health and HIV national guideline for the management of anogenital warts in adults (2024) Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-08 Diarmuid Nugent, Ade Apoola, Harry Coleman, Cindy Gilmour, Mark David Lawton, Achyuta Nori, Jonathan D C Ross, Gary Whitlock, Hannah Yeend-Curd-Trimble
This guideline offers recommendations on the diagnosis, treatment and health promotion principles needed for the effective management of human papillomavirus (HPV)-related warts at anogenital sites including the external genitals, vagina, cervix, urethra, perianus and anal canal. The guideline is aimed primarily at patients aged 16 years or older presenting to healthcare professionals working in level
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Intrapersonal, interpersonal, and institutional levels of minority stigma among sexual minority males in the Philippines Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-05 Rowalt Alibudbud
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Insights into ocular syphilis in Nepal Int. J. STD AIDS (IF 1.4) Pub Date : 2024-03-01 Sadhana Sharma, Ranju Kharel, Sanket Parajuli, Ruchi Shrestha, Shradha Tiwari, Himang Singh Maskey
PurposeThis study aims to elucidate the demographic characteristics, clinical features, diagnostic approaches, and medical management of patients with ocular syphilis, known as ‘the great masquerader,’ at a tertiary eye care center in Nepal.MethodsWe conducted a retrospective review involving 15 eyes from ten patients with ocular syphilis treated at a uveitis referral center between 2020 and 2022.
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Slovenia‘s national HIV PrEP programme: Evaluation of real-world implementation Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-21 Jerca Ambrožič, Peter Adamič, Janez Tomažič
BackgroundThe aim of our study was to evaluate real-world implementation of Slovenia’s national HIV PrEP programme, which is fully covered by our national health insurance.MethodsIn retrospective cohort study we analysed the data from all men who have sex with men (MSM) who were enrolled in PrEP programme of our clinic between 1 January 2022 and 31 December 2022.ResultsA total of 190 MSM with an average
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Waist circumference and cardiometabolic parameters in people of African/Caribbean ancestry with HIV in South London (CKD-AFRICA study) Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-20 Laura Cechin, Lourdes Dominguez-Dominguez, Lucy Campbell, Lisa Hamzah, Julie Fox, Royce P Vincent, Georgios K Dimitriadis, Louise Goff, Frank A Post
BackgroundThere are no validated waist circumference (WC) cut-offs to define metabolic syndrome in Black people with HIV.MethodsCross-sectional analyses within the CKD-AFRICA study. We used Pearson correlation coefficients and receiver operating characteristic (ROC) curves to describe the relationship between WC and cardiometabolic parameters including triglycerides, cholesterol, glucose, glycated
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COVID-19 epidemiology and performance of the WHO clinical algorithm to diagnose COVID-19 in people with HIV from Ukraine Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-06 Marta Vasylyev, Vira Buhiichyk, Nadiia Buhiichyck, Albert Groenendijk, Iryna Ben, Lesya Ostapiuk, Maryana Sluzhynska, Wouter F.W. Bierman, Jeroen J.A. van Kampen, Ferdinand W.N.M. Wit, Peter Reiss, Bart J.A. Rijnders, Oleksandra Sluzhynska, Casper Rokx
BackgroundThe two main objectives were to evaluate the COVID-19 point prevalence and the test performance of the WHO case definition to diagnose COVID-19 clinically in people with HIV in West Ukraine.MethodsMulticenter cross-sectional study in Lviv, Ukraine, from October 2020-November 2021. COVID-19 unvaccinated people with HIV were included regardless of COVID-19 symptoms at routine clinical visits
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Sepsis and multi-organ failure due to genital herpes in a healthy person Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-05 Ruolin Li, Junying Zhou
Herpes simplex virus type 2 (HSV-2) is highly prevalent in several regions of the world and is the main pathogen causing genital herpes, which is transmitted almost exclusively through sexual contact. Systemically disseminated infections caused by HSV-2 are rare and most often seen in newborns, pregnant women, or immunocompromised populations. The virus can invade multiple organs and cause damage.
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Social support as a mediator between mental health and stigma among newly HIV-positive men who have sex with men Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-05 Yafang Zhao, Kaveh Khoshnood, Yu Sheng
ObjectivesThe sociocultural context of China gives rise to unique experiences of HIV-related stigma and adverse impacts on mental health among men who have sex with men (MSM) living with HIV. However, few studies have explored the stigma among families in the cultural context of China and the role of social support as a mediator to explain how HIV-related stigma results in poor psychological well-being
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Phenotypic and genotypic characterization of Neisseria gonorrhoeae isolates among individuals at high risk for sexually transmitted diseases in Zurich, Switzerland Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-01 Christian Jünger, Frank Imkamp, Suraj Balakrishna, Marina Gysin, Klara Haldimann, Silvio D Brugger, Thomas C Scheier, Benjamin Hampel, Sven N Hobbie, Huldrych F Günthard, Dominique L Braun
BackgroundWhile ceftriaxone resistance remains scarce in Switzerland, global Neisseria gonorrhoeae (NG) antimicrobial resistance poses an urgent threat. This study describes clinical characteristics in MSM (men who have sex with men) diagnosed with NG infection and analyses NG resistance by phenotypic and genotypic means.MethodsData of MSM enrolled in three clinical cohorts with a positive polymerase
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Improving awareness and uptake of pre-exposure HIV prophylaxis amongst service users accessing Sexual Health London, a regional online postal sexually transmitted infection testing health service Int. J. STD AIDS (IF 1.4) Pub Date : 2024-02-01 Curran Caoimhe, Jonathan Spate, Sara Day
BackgroundThe UK pledged commitment to the global strategy of zero new HIV infections and HIV-related deaths by 2030. PrEP was commissioned in England in 2020 and is fundamental to achieving these targets, yet awareness and uptake are suboptimal in certain populations.MethodSexual Health London (SHL) incorporated questions on its e-triage questionnaire estimating need for PrEP amongst online service
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Prevalence, risk factors and genotyping of chlamydia trachomatis from endocervical specimens of infertile women at a tertiary care hospital, Vietnam Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-31 Hoa Nguyen, Anh Do Ngoc, Van Nguyen Le, Nhu Quynh Nguyen Thi, Yen Hoang Thi, Canh Dinh Hoang, Phuc Tran Quang, Du Vu Van
BackgroundTo our knowledge, the prevalence, risk factors and distribution of C. trachomatis genotypes are rarely mentioned in Vietnam. This study aimed to find the prevalence, risk factors and distribution of C. trachomatis genotypes in infertile Vietnamese women.MethodsEndocervical swabs were collected from infertile women at the National Hospital of Obstetrics and Gynecology, Vietnam, between January
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An unusual co-reactivation of herpes genitalis and shingles in a young male with primary genital herpes in partner Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-23 Subhajit Sadhukhan, Suman Patra, Ravisekhar Gadepalli, Maninder Kaur
BackgroundHerpes simplex virus type 2 (HSV-2) is the most common cause of genital ulcers in industrialized countries. Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of the varicella-zoster virus (VZV).Case SummaryA 27-year-old male presented with painful vesicles over the trunk for the last 5 days with painful genital erosions for the last 2 days. His spouse also
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Human immunodeficiency virus prevention outcomes associated with arts-based sexual health workshop participation among Northern and Indigenous adolescents in the Northwest Territories, Canada Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-23 Candice L Lys, Carmen H Logie, Anoushka Lad, Nina Sokolovic, Kayley Inuksuk Mackay, Aryssa Hasham, Kalonde Malama
BackgroundContextually tailored, arts-based HIV prevention strategies hold potential to advance adolescent sexual health and wellbeing. We examined HIV prevention outcomes associated with arts-based sexual health workshop participation with Northern and Indigenous adolescents in the Northwest Territories (NWT), Canada.MethodsAn Indigenous community-based youth agency delivered arts-based workshops
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Comparison of clinician preference and HIV-ASSIST recommendations in antiretroviral therapy decision-making: A single center experience from Turkiye Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-23 Ilkay Akbulut, Ilker Odemis, Sabri Atalay, Ahmet Cagkan Inkaya
Background: HIV-ASSIST is a free, continuously updated, clinically validated online algorithm tool that synthesizes participant- and virus-specific characteristics and provides ART decision support based on the goals of maximizing viral suppression and tolerability. The aim of this study was to analyze the concordance of clinicians’ ART preferences with HIV-ASSIST recommendations and the influencing
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Prevalence and risk factors of sexually transmitted infections in the setting of a generalized HIV epidemic—a population-based study, western Kenya Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-19 Hellen Carolyne Awuoche, Rachael H Joseph, Faith Magut, Sammy Khagayi, Fredrick S Odongo, Moses Otieno, Aoko Appolonia, Elijah Odoyo-June, Daniel O Kwaro
BackgroundSexually transmitted infections (STIs) cause adverse health outcomes, including increasing HIV acquisition/transmission risk. We analyzed data from an HIV biomarker and behavioral survey to estimate STI prevalence, and explore associated factors in the setting of a generalized HIV epidemic in Siaya County, western Kenya.MethodsData were collected in March–September 2022 through face-to-face
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Improving partner notification for sexually transmitted infections: Interviews with key informants in Aotearoa New Zealand Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-16 Catriona Murray, Sally B Rose
BackgroundPartner notification is a vital part of sexually transmitted infection (STI) control but evidence suggests that its practice in Aotearoa New Zealand (NZ) is inconsistent. This study sought to explore barriers to partner notification for STIs, identify areas for improvement and draw on lessons learnt from Covid-19.MethodsSemi-structured interviews with key informants working in primary care
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Trichomoniasis and retesting in Durham County, North Carolina, United States, 2021 - 2022 Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-16 Jeffrey D. Jenks, Emily Ryan, Candy Stancil, Kimberly Harris, Lizeth Hester, Savannah Carrico, Marissa Mortiboy, John-Paul Zitta
BackgroundThe Centers for Disease Control and Prevention recommends universal retesting within 3 months after treatment of Trichomonas vaginalis infection given high rates of persistent infection or reinfection, or if this is not possible, within 12 months following treatment. Data is lacking on how often this is actually done.MethodsWe analyzed the demographic and clinical characteristics, rate of
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Effect of the timing of antiretroviral treatment initiation on CD4 count in children and youths living with HIV in North India Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-12 Mukesh Vir Singh, Sukesh Sharma, Anubha Shrivastava, Santosh Kumar Shukla, Shahid Akhtar Siddiqui, Manisha Maurya, Nandita Mishra, Rajesh Kumar Yadav
BackgroundImmediate start of antiretroviral treatment (ART) among non-hospitalized outpatient children living with HIV may improve or worsen clinical outcomes due to immune reconstitution.ObjectiveRole of immediate versus post-stabilization start of antiretroviral treatment in children and youths living with HIV on CD4 count and viral load suppression.MethodsThis was a single blinded, randomized controlled
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Prospective screening for monkeypox infection among users of HIV pre-exposure prophylaxis in Denmark Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-02 Sofie Ellen Thomassen, Sebastian von Schreeb, Nikolai Søren Kirkby, Mette Pinholt, Anne-Mette Lebech, Gitte Kronborg, Frederik Neess Engsig
IntroductionDuring the 2022 outbreak of mpox (previously called monkeypox), which primarily affected Gay, Bisexual, and other Men who have Sex with Men (GBMSM), testing was mainly limited to individuals with symptoms of infection. Although sporadic cases of mpox continue to be diagnosed in Denmark, the feasibility of screening asymptomatic high-risk populations, such as those using HIV pre-exposure
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Orogenital and anal infection by Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and other sexually transmitted infections in men who have sex with men in Lisbon Int. J. STD AIDS (IF 1.4) Pub Date : 2024-01-02 Corrado Minetti, Miguel Rocha, Luís Miguel Duque, Paula Meireles, Cristina Correia, Dora Cordeiro, Inês João, Carla Manita, Sofia Soeiro, João Almeida Santos, Rita Matos, Catarina Almeida, Helena Cortes Martins, Elsa Vinagre, Sílvia Lopo, Maria José Borrego
BackgroundMen who have sex with men (MSM) are at risk for sexually transmitted infections (STIs), but more data on extragenital carriage are needed.AimWe assessed the genital and extragenital prevalence of bacterial and other STIs in MSM in a Lisbon sexual health clinic.MethodsWe screened oral, anal, and urine samples of MSM visiting the GAT-CheckpointLX clinic June 2017-December 2021 for Chlamydia
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Pseudotumoral herpes genitalis in a woman living with HIV: Diagnosis and treatment challenges. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-30 María V Tomaino,Macarena Sanchez Costantini,Carmen T Alfaro
Herpes simplex virus (HSV) is the leading cause of genital ulcers worldwide. In rare cases, mostly among immunocompromised hosts, HSV infections can present as hypertrophic pseudotumoral forms simulating malignancies or often mistaken as other viral infections, usually resistant to conventional antiviral therapy and often requiring alternative therapeutic approaches. A high level of clinical suspicion
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Tackling late HIV diagnosis: Lessons from the UK in the COVID-19 era. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-28 Emily Boardman,Marta Boffito,David R Chadwick,Emily Cheserem,Samuel Kabagambe,Bakita Kasadha,Cindy Elliott
INTRODUCTION Late diagnosis of HIV is associated with increased morbidity and mortality, and an increased risk of non-infectious comorbidities. On a societal level, late diagnosis leads to higher treatment and healthcare costs and is a major driver of HIV transmission. Despite improvements in other areas of the HIV care pathway, late diagnosis remains an individual and public health concern globally
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Direct switch from an efavirenz-based regimen to intramuscular long-acting cabotegravir plus rilpivirine: A case report. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-24 Elizabeth Senkoro,Margherita Bracchi,Joseph Heskin,Yasmin Walters,Maithili Varadarajan,Christina Antoniadi,Yaser Al-Shakarchi,Nicolo Girometti,Marta Boffito
Switching from oral antiretroviral treatment to intramuscular (IM) cabotegravir (CAB) + rilpivirine (RPV) has an optional oral lead-in to ensure tolerability. The British HIV Association guidelines advise against directly switching from oral antiretroviral (ART) combinations containing strong/moderate cytochrome inducers like efavirenz (EFV) to IM CAB + RPV. EFV has a prolonged elimination half-life
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Sub-optimal routine HIV testing rates in an urban HIV and infectious disease clinic. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-21 Cristiana Grace Salvatori,Maniraj Jeyaraju,Sarah Ann Schmalzle
Background: Routine opt-out HIV testing is central to ending the HIV epidemic, as early case finding improves outcomes and reduces transmission. Despite strong evidence-based guideline recommendations, adoption of routine opt-out testing has been sub-optimal. Methods: A survey of providers and staff at an urban HIV and infectious disease clinic assessed awareness and knowledge of guidelines, screening
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Real world utilisation of doravirine among people living with human immunodeficiency virus in England (DRIVE-REAL). Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-16 Charlotte O'Halloran,Yvonne Gilleece,Suki Leung,Veronica Canuto,Connor McAlpine,Sophie Ross,Claire Norcross,Stuart Gaffney,Nipur Siani,William Hickey,Adam Moore,Olivera Rajkovic-Hooley,Ana Milinkovic
BACKGROUND Doravirine is a non-nucleoside reverse transcriptase inhibitor recommended for the treatment of virologically suppressed and treatment naïve people living with HIV. The DRIVE-REAL study aimed to describe the characteristics, treatment patterns, and virological outcomes of doravirine users in a real-world cohort in the UK. METHODS A retrospective, observational, multi-centre chart review
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Evaluation of self-directed specimen collection for chlamydia and gonorrhea testing among people who use drugs. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-16 Joy D Scheidell,Luther C Elliott,Alex S Bennett,Muthoni Mahachi,Dana Lapple,Julie Ae Nelson,Marcia M Hobbs
Background: People who use drugs (PWUD) often have elevated sexually transmitted infection (STI) risk and unmet healthcare needs. Self-directed STI specimen collection (i.e., individuals collect the specimen and mail to the laboratory) may be valuable in addressing STI testing barriers among PWUD. Methods: Within a cohort study among PWUD in New York City, we conducted a cross-sectional substudy from
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Increase in human immunodeficiency virus and syphilis prevalence and incidence among men who have sex with men, vietnam 2015 - 2020. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-15 Ha Thi Thanh Nguyen,Ly Thuy Nguyen,Ha Thi Thanh Hoang,Duc Hoang Bui,Huong Thi Thu Phan,Nghia Van Khuu,Hanh Thi Hong Ngo,Duc Anh Dang,Ali Mirzazadeh,Willi McFarland,Thang Hong Pham
INTRODUCTION We assessed trends in HIV and syphilis prevalence, HIV incidence, related risk factors, and preventive behaviors among men who have sex with men (MSM) in Vietnam from 2015 to 2020. METHODS Data originated from the HIV Sentinel Surveillance Plus system, which sampled MSM at venues and hotspots in seven of Vietnam's 63 provinces in 2015, 2016, 2018, and 2020 (N = 1100-1445 per year; ∼150-300
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Factors associated with discussing HIV pre-exposure prophylaxis (PrEP) among Jamaican medical providers. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-15 Melonie M Walcott,Hong-Van Tieu,Meghan Tipre,Vijay Nandi,Alissa Davis,Elwin Wu,Marceleen Wheatle,Victoria Frye,J Peter Figueroa
BACKGROUND The Ministry of Health and Wellness of Jamaica has endorsed the use of pre-exposure prophylaxis (PrEP) as an HIV prevention strategy; however, PrEP was not included in the national HIV prevention program in 2021. METHODS A cross-sectional online study involving physicians in Jamaica was conducted in 2021 to describe PrEP awareness, beliefs, attitudes, and practices. The study also assessed
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Pyogenic spondylodiscitis in HIV-positive patients under antiretroviral therapy: A case series. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-14 Maria Kitchen,Irina Gasslitter,Martin Gisinger,Johannes Deeg,Armin Rieger,Mario Sarcletti
Background: The incidence of pyogenic spondylodiscitis has been increasing in countries of Europe and North America, probably due to an increasing number of persons with risk factors for this infection. It is unclear whether HIV infection in the era of antiretroviral therapy (ART) increases the risk for spondylodiscitis. Method: We present 7 cases of pyogenic spondylodiscitis of the cervical, thoracic
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Appropriate usage of post-exposure prophylaxis-in-pocket for HIV prevention by individuals with low-frequency exposures. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-14 Matthew Clifford Rashotte,Deborah Yoong,Mark Naccarato,Oscar J Pico Espinosa,Karla Fisher,Isaac I Bogoch,Darrell Hs Tan
PEP-In-Pocket (Post-Exposure Prophylaxis-In-Pocket, or "PIP") is a biobehavioural HIV prevention strategy wherein patients are proactively identified and given a prescription for HIV post-exposure prophylaxis (PEP) medications to self-initiate in case of high-risk exposures. We evaluated this strategy in a prospective observational study at two hospital-based clinics in Toronto, Canada. HIV-negative
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The association between stigma and wellbeing in an Italian cohort of PLWH: The role of social support and personal factors. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-13 Valentina Delle Donne,Valentina Massaroni,Francesca Lombardi,Alex Dusina,Pierluigi Francesco Salvo,Alberto Borghetti,Arturo Ciccullo,Elena Visconti,Simona Di Giambenedetto
Our aim was to assess the association between different types of stigma and physical, behavioural and emotional wellbeing, and to evaluate whether these associations were mediated by the level of social support, age, education, sex and time from HIV diagnosis in an Italian cohort of people living with HIV (PLWH). We enrolled 96 PLWH and had them complete a cross-sectional online survey that included
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Beyond-66: A pilot evaluation of a novel, peer-led harm reduction intervention for chemsex dependant men who have sex with men in Kuala Lumpur, Malaysia. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-08 Benjamin Km Thain,Richard Lu,Colin Fitzpatrick,Daniel Richardson
BACKGROUND There is little research exploring harm reduction interventions for men who have sex with men (MSM) who engage in chemsex. Beyond-66 is a novel, 132-day, peer-led intervention programme for MSM who are chemsex dependent in Kuala Lumpur, Malaysia. We aimed to evaluate the feasibility, retention and effect of Beyond-66 on: abstinence from chemsex, motivation for abstinence, and mental wellbeing
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Recalcitrant ulcerative genital herpes in an immunocompetent individual treated successfully with imiquimod. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-08 Suvigya Sachan,Vijay Kiran Potluri,Hima Gopinath,Kode Leela Sravanthi,Prabhakaran N,Jyotsna Naresh Bharti,Thiruveedhula Haritha
BACKGROUND This case report describes the successful use of imiquimod to treat genital herpes in an immunocompetent individual with acyclovir-resistant HSV. CASE REPORT A 32 year old male patient, presented with asymptomatic non-healing ulcers over the genital region for 2 years. The ulcers initially responded to acyclovir but became persistent after a few months. He also received multiple courses
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Does genital herpes symptom history predict herpes simplex virus type 2 antibody positivity? Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-08 Jessica Perez,Katherine A Lewis,Silver Vargas,Jeffrey D Klausner,Kelika A Konda
BACKGROUND Sexually transmitted infections (STIs) associated with genital ulcer disease due to herpes simplex virus-2 (HSV-2) are a prominent cause of morbidity and mortality. Serologic screening for HSV-2 is recommended only for individuals with genital herpes symptom history. However, no validated symptom screening tool currently exists. METHODS Currently asymptomatic adults presenting for routine
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Substance use, economic vulnerability, and HIV/STI risk among female sex workers in Mexico. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-07 Marissa Salazar,Jay G Silverman,María Gudelia Rangel Gómez,Lianne A Urada,Kimberly C Brouwer,Elizabeth Reed
BACKGROUND Economic hardship (e.g., difficulty to pay for basic needs) has been associated with increased HIV/STI risk among female sex workers (FSW), and may be exacerbated by high levels of substance use. Few studies have assessed the intersection of economic hardship, substance use, and HIV/STI risk among FSW. METHODS Quantitative data were collected via questionnaires among 469 FSW residing in
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Virologic outcomes of antiretroviral therapy in patients with HIV-1 following bariatric surgery: A case series and review of the literature. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-07 Melissa Badowski,Sally Kassem,Malgorzata Labedz,Christopher Taylor,Kristen Bunnell,Ashley Hall,Hannah Darnell,Emily Huesgen
BACKGROUND Selection of an antiretroviral regimen for people living with HIV (PLWH) involves various clinical considerations, such as comorbidities, archived drug resistance mutations, concomitant medications, and potential drug interactions and side effects. Alterations in the surface area and pH of the gastrointestinal tract following bariatric surgery may alter absorption, antiretroviral pharmacokinetics
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Fournier's gangrene of the penis complicating both COVID-19- and Mpox-related genital ulceration - A case report. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-06 Karolina Louisa Suzanna Kerkemeyer,Christopher Barry Bunker,Karl H Pang,Hussain Murtaza Alnajjar,Asif Muneer,Alex Freeman
Fournier's gangrene is a rare, rapidly progressive, fulminant form of infective necrotising fasciitis of the genital, perianal and perineal regions. We present a case of Fournier's gangrene of the penis complicating acute genital ulceration and recurrent paraphimosis that was secondary to contemporaneous COVID-19 and Mpox infection in an otherwise healthy 41-year-old man. It is important for clinicians
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Associated factors of malnutrition status among children and adolescents living with HIV in Tanzania: Individual-level analysis and marginal effect estimation. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-11-01 Samuel Chacha,Jing Hui,Teng Yuxin,Wang Ziping,Huang Yan,Saumu Ali,Wahida Abeid,William Dominick,Emmanuel Malimu,Florian Emanuel,Saidi Saidi,Deogratias Lyimo,Veronica Mwanyika,Elfrida Kumalija,Shaonong Dang
OBJECTIVES This study aimed to identify individual-level factors that affect malnutrition outcomes among children and adolescents living with HIV/AIDS in Tanzania. METHODS We used data from the National AIDS Control Programme. 70,102 participants aged 5 to 19 years attending care and treatment clinics between January to December 2021 were included. Nutritional assessments were performed by anthropometric
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Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis - a single centre experience. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-10-23 Ilona Hartmane,Iveta Ivdra,Ingmars Mikazans,Aleksejs Princevs,Irena Teterina,Vanda Bondare-Ansberga,Lelde Reinberga
BACKGROUND There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy. METHODS A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted. RESULTS No cases of intolerance, Jarisch-Herxheimer
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Genitourinary medicine consultant workforce in England 2023 - establishing the true numbers. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-10-16 Jackie Sherrard,Clare Shanks,Elzabeth Foley
Workforce planning of future requirements depends on accurate data and the GUM consultant and trainee workforce is reviewed annually by Health Education England (HEE) and the Royal College of Physicians (RCP) to make recommendations for specialty training numbers. A deep dive exercise in 2017 undertaken with HEE revealed that the headcount was reasonably accurate but there was much less certainty around
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U=U should also include information on blood transfusion transmission. Int. J. STD AIDS (IF 1.4) Pub Date : 2023-10-13 Edson Zangiacomi Martinez,Miriane Lucindo Zucoloto