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Pharmacological profile of agmatine: An in-depth overview Neuropeptides (IF 2.9) Pub Date : 2024-04-03 Hira Rafi, Hamna Rafiq, Muhammad Farhan
Agmatine, a naturally occurring polyamine derived from arginine via arginine decarboxylase, has been shown to play multifaceted roles in the mammalian body, impacting a wide range of physiological and pathological processes. This comprehensive review delineates the significant insights into agmatine's pharmacological profile, emphasizing its structure and metabolism, neurotransmission and regulation
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Fat mass and obesity-associated protein regulates RNA methylation associated with spatial cognitive dysfunction after chronic cerebral hypoperfusion Neuropeptides (IF 2.9) Pub Date : 2024-04-03 Yanqing Wang, Zimei Wu, Yuyang He, Xiaoying Zeng, Zijuan Gu, Xianxi Zhou, Wenwen Si, Dongfeng Chen
RNA methylation can epigenetically regulate learning and memory. However, it is unclear whether RNA methylation plays a critical role in the pathophysiology of Vascular dementia (VD). Here, we report that expression of the fat mass and obesity associated gene (FTO), an RNA demethylase, is downregulated in the hippocampus in models of VD. Through prediction and dual-luciferase reporters validation studies
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Neurocircuitry underlying the actions of glucagon-like peptide 1 and peptide YY3–36 in the suppression of food, drug-seeking, and anxiogenesis Neuropeptides (IF 2.9) Pub Date : 2024-03-30 Yasmina Dumiaty, Brett M. Underwood, Jenny Phy-Lim, Melissa J. Chee
Obesity is a critical health condition worldwide that increases the risks of comorbid chronic diseases, but it can be managed with weight loss. However, conventional interventions relying on diet and exercise are inadequate for achieving and maintaining weight loss, thus there is significant market interest for pharmaceutical anti-obesity agents. For decades, receptor agonists for the gut peptide glucagon-like
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Galectin-9 and Tim-3 are upregulated in response to microglial activation induced by the peptide Amyloid-β (25–35) Neuropeptides (IF 2.9) Pub Date : 2024-03-21 Eleazar Ramírez Hernández, Luis Fernando Hernández Zimbrón, Emmanuel Segura Pérez, José Luis Sánchez Salgado, Mohamed Ali Pereyra Morales, Edgar Zenteno
Galectins are a group of β-galactoside-binding lectins associated with regulating immunological response. In the brains of AD patients and 5xFAD (familial AD) mice, galectin-3 (Gal-3) was highly upregulated and found to be expressed in microglia associated with Aβ plaques. However, the participation of other galectins, specifically galectin-9 (Gal-9) and T-cell immunoglobulin and mucin domain 3 (Tim-3)
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Important role of NPY-Y4R signalling in the dual control of feeding and physical activity Neuropeptides (IF 2.9) Pub Date : 2024-03-18 Lei Zhang, Herbert Herzog
The control of feeding and physical activity is tightly linked and coordinated. However the underlying mechanisms are unclear. One of the major regulatory systems of feeding behaviour involves neuropeptide Y (NPY) signalling, with the signalling mediated through NPY Y4 receptor also known to influence activity. Here we show that mice globally lacking the () in the absence of access to a running wheel
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Baroreflex afferent function is a part of insights of Leptin-mediated blood pressure reduction and Leptin-resistance hypertension Neuropeptides (IF 2.9) Pub Date : 2024-02-29 Shi-gang Ren, Dong-mei Li, Hua Liu
The aim of this study is to verify the impact of Leptin in blood pressure (BP) regulation and Leptin-resistance in metabolic/neurogenic hypertension through baroreflex afferents and dysregulation. Artery BP/heart rate (HR) were measured while nodose (NG) microinjection of Leptin, membrane depolarization/inward current were obtained by whole-cell patch from NG neurons isolated from adult female rats
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Illuminating the neuropeptide Y4 receptor and its ligand pancreatic polypeptide from a structural, functional, and therapeutic perspective Neuropeptides (IF 2.9) Pub Date : 2024-02-24 Corinna Schüß, Victoria Behr, Annette G. Beck-Sickinger
The neuropeptide Y receptor (YR), a rhodopsin-like G protein-coupled receptor (GPCR) and the hormone pancreatic polypeptide (PP) are members of the neuropeptide Y family consisting of four receptors (YR, YR, YR, YR) and three highly homologous peptide ligands (neuropeptide Y, peptide YY, PP). In this family, the YR is of particular interest as it is the only subtype with high affinity to PP over NPY
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Peripheral administration of lipidized NPAF and NPFF analogs does not influence central food intake regulation but induces anxiety-like behavior Neuropeptides (IF 2.9) Pub Date : 2024-02-23 Veronika Strnadová, Alena Morgan, Magdalena Škrlová, Eliška Haasová, Kristina Bardová, Aneta Myšková, David Sýkora, Jaroslav Kuneš, Blanka Železná, Lenka Maletínská
RF-amide peptides influence multiple physiological processes, including the regulation of appetite, stress responses, behavior, and reproductive and endocrine functions. In this study, we examined the roles of neuropeptide FF receptors (NPFFR1 and NPFFR2) by generating several lipidized analogs of neuropeptide AF (NPAF) and 1DMe, a stable analog of neuropeptide FF (NPFF). These analogs were administered
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A recent update on drugs and alternative approaches for parkinsonism Neuropeptides (IF 2.9) Pub Date : 2024-02-21 Sneha Kispotta, Debajyoti Das, Shakti Ketan Prusty
, often known as PD, is a more common age-related neurological disorder that affects a huge number of older adults worldwide. Parkinson's disease is predominantly a movement-related pathosis and is distinguished by the deposition of intra-neuronal aggregates, as the alpha-synuclein gene is expressed as Lewy bodies (LB) causing dopaminergic neurons to die. Stress in early life may contribute to the
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Perioperative changes of serum orphanin in diabetic patients and its relationship with sympathetic nervous system Neuropeptides (IF 2.9) Pub Date : 2024-02-16 Lin-Zhong Zhang, Meng-Li Xie, Jing Li, Yu-Zhang Liang, Si-Kun Chen, Yi Han
The occurrence of cardiovascular events in diabetic patients during the perioperative period is related to the activation of sympathetic nerves. Basic research shows that serum nociceptin/orphanin FQ (N/OFQ) levels in diabetic neuropathy rats increased, and N/OFQ reduces the release of norepinephrine (NE). We hypothesize that N/OFQ will affect the sympathetic nervous system during perioperative myocardium
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Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes Neuropeptides (IF 2.9) Pub Date : 2024-02-05 Luis López, Kelly Lozano, John Cruz, Krystal Flores, Lauren Fernández-Vega, Lisandro Cunci
The measurement of neuropeptides using small electrodes for high spatial resolution would provide us with localized information on the release of neuromolecules. The release of Neuropeptide Y (NPY) is related to different neurological diseases such as stress, obesity, and PTSD, among others. In this conference paper, we electrodeposited polypyrrole on carbon fiber microelectrodes in the presence of
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The role of NPY signaling pathway in diagnosis, prognosis and treatment of stroke Neuropeptides (IF 2.9) Pub Date : 2024-02-04 Taotao Jiang, Ting Zheng, Rundong Li, Jingjing Sun, Xiaoqing Luan, Manxia Wang
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Localization of truncated TrkB and co-expression with full-length TrkB in the cerebral cortex of adult mice Neuropeptides (IF 2.9) Pub Date : 2024-01-29 K, o, j, i, , O, h, i, r, a
Brain-derived neurotrophic factor (BDNF), one of the neurotrophins, and its specific receptor TrkB, are abundantly distributed in the central nervous system (CNS) and have a variety of biological effects, such as neural survival, neurite elongation, neural differentiation, and enhancing synaptic functions. Currently, there are two TrkB subtypes: full-length TrkB (TrkB-FL), which has a tyrosine kinase
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A comparative study on the effects of human serum albumin and α-melanocyte-stimulating hormone fusion proteins on the anti-neuroinflammatory in the central nervous system of adult mice Neuropeptides (IF 2.9) Pub Date : 2024-01-23 Yiyao Liu, Yang Li, Xueyan Wei, Inam Ullah, Shahab Uddin, Jiatao Wang, Runjie Xia, Meizhu Wang, Hui Yang, Hongyu Li
The immunomodulatory effects of α-melanocyte stimulating hormone (α-MSH) in the central nervous system (CNS) have been investigated for forty years. The clinical applications of α-MSH are limited due to its short half-life. Our previous study has indicated that the short half-life of α-MSH can be extended by fusion with carrier human serum albumin (HSA) and this fusion protein has also retained the
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Cyclooxygenase-2 inhibition affects the ratio of GluN2A/GluN2B receptor subunits through interaction with mGluR5 in the mouse brain Neuropeptides (IF 2.9) Pub Date : 2024-01-17 Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Szymon Rzeźniczek, Magdalena Sowa-Kućma
-methyl-D-aspartic acid receptors (NMDARs) are the most studied receptors in mammalian brains. Their role in depression, cognition, schizophrenia, learning and memorization, Alzheimer's disease, and more is well documented. In the search for new drug candidates in depression, intensive studies have been conducted. Compounds that act by influencing NMDARs have been particularly intensively investigated
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Immunohistochemical determination of the excitatory and inhibitory axonal endings contacting NUCB2/nesfatin-1 neurons Neuropeptides (IF 2.9) Pub Date : 2023-12-25 Aynura Aghayeva, Duygu Gok Yurtseven, Nursel Hasanoglu Akbulut, Ozhan Eyigor
Nesfatin-1 is an anorexigenic peptide suppressing food intake and is synthesized and secreted by neurons located in the hypothalamus. Our study was aimed to demonstrate the effect of excitatory and inhibitory neurotransmitters on NUCB2/nesfatin-1 neurons. In this context, dual peroxidase immunohistochemistry staining was performed using NUCB2/nesfatin-1 primary antibody with each of the primary antibodies
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WITHDRAWN: CircBUB1 activates the PI3K/AKT signaling pathway to promote the migration and invasion of glioblastoma cells Neuropeptides (IF 2.9) Pub Date : 2023-12-13 Runan Zhang, Dongmei Wu, Ying Wang, Liping Wu, Guowei Gao, Dayong Shan
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
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Effects of somatostatin, a somatostatin agonist, and an antagonist, on a putative migraine trigger pathway Neuropeptides (IF 2.9) Pub Date : 2023-12-12 Geoffrey A. Lambert, Alessandro S. Zagami
Objective To determine whether somatostatin (SST) could be a cortico-brainstem neurotransmitter involved in producing the headache of migraine. Background There is evidence to support the idea that a cortico-brainstem-trigeminal nucleus neuraxis might be responsible for producing migraine headache; we have suggested that SST may be one of the neurotransmitters involved. Methods Rats were anesthetised
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New fraternine analogues: Evaluation of the antiparkinsonian effect in the model of Parkinson's disease Neuropeptides (IF 2.9) Pub Date : 2023-11-13 Andréia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Júnio Araújo de Castro, Anamélia Lorenzetti Bocca, Márcia Renata Mortari
Venom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with promising effects for the treatment of Parkinson's disease. In the present paper, we synthesized three peptides bioinspired in fraternine: fra-10, fra-14, and fra-24
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Effect of valproic acid combined with transplantation of olfactory ensheathing cells modified by neurotrophic 3 gene on nerve protection and repair after traumatic brain injury Neuropeptides (IF 2.9) Pub Date : 2023-10-26 Haiming Li, Zhijie Yin, Shuangzhu Yue, Yunying An, Xiaoyin Wang, Shifang Zhou, Lei Meng, Baozhe Jin
Background Traumatic brain injury (TBI) often leads to cognitive and neurological dysfunction. Valproic acid (VPA) has a neuroprotective effect in acute central nervous system diseases; the neurotrophin 3 gene (NT-3) can maintain the survival of neurons, and olfactory ensheathing cells (OECs) can promote the growth of nerve axons. This study aimed to evaluate the restorative effect of VPA combined
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Cross talk about the role of Neuropeptide Y in CNS disorders and diseases Neuropeptides (IF 2.9) Pub Date : 2023-10-24 Rajeshwari Bale, Gaurav Doshi
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The use of intranasal oxytocin in the treatment of eating disorders Neuropeptides (IF 2.9) Pub Date : 2023-10-12 Magda Malewska-Kasprzak, Katarzyna Jowik, Marta Tyszkiewicz-Nwafor
Oxytocin (OXT) is a hypothalamic peptide that plays a number of roles in the body, being involved in labor and lactation, as well as cognitive-emotional processes and social behavior. In recent years, knowledge of the physiology of OXT has been repeatedly used to explore its potential role in the treatment of numerous diseases, identifying a significant role for OXT in appetite regulation, eating behavior
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CDNF overexpression prevents motor-cognitive dysfunction by intrastriatal CPP-based delivery system in a Parkinson's disease animal model Neuropeptides (IF 2.9) Pub Date : 2023-10-11 Sheila A. Villa-Cedillo, Daniel Matta-Yee-Chig, Adolfo Soto-Domínguez, Humberto Rodríguez-Rocha, Aracely García-García, Carlos R. Montes-de-Oca-Saucedo, María de Jesús Loera-Arias, Jesús Valdés, Odila Saucedo-Cárdenas
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compact (SNpc), and no effective treatment has yet been established to prevent PD. Neurotrophic factors, such as cerebral dopamine neurotrophic factor (CDNF), have shown a neuroprotective effect on dopaminergic neurons. Previously, we developed a cell-penetrating-peptide-based delivery system
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Neuroprotective effect of the PACAP-ADNP axis on SOD1G93A mutant motor neuron death induced by trophic factors deprivation Neuropeptides (IF 2.9) Pub Date : 2023-10-11 Benedetta Magrì, Agata Grazia D'Amico, Grazia Maugeri, Giovanna Morello, Valentina La Cognata, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
Amyotrophic lateral Sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of motor neurons in the central nervous system. Mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) account for approximately in 20% of familial ALS cases. The pathological mechanisms underlying the toxicity induced by mutated SOD1 are still unknown. However, it has been hypothesized
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Improvement of actin dynamics and cognitive impairment in diabetes through troxerutin-mediated downregulation of TRPM7/CaN/cofilin Neuropeptides (IF 2.9) Pub Date : 2023-09-28 Hongyan Li, Jie Li, Pin Wang, Fang Yuan, Songyun Zhang
Diabetic cognitive impairment is a central nervous complication of diabetes mellitus. Its specific pathogenesis is unknown, and no effective treatment strategy is currently available. An imbalance in actin dynamics is an important mechanism underlying cognitive impairment. Transient receptor potential channel 7 (TRPM7) mediates actin dynamics imbalance through calcineurin (CaN) and cofilin cascades
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Dissecting the functional significance of HSP90AB1 and other heat shock proteins in countering glioblastomas and ependymomas using omics analysis and drug prediction using virtual screening Neuropeptides (IF 2.9) Pub Date : 2023-09-14 Sudhanshu Sharma, Pravir Kumar
Heat shock proteins (HSPs) are the evolutionary family of proteins that are highly conserved and present widely in various organisms and play an array of important roles and cellular functions. Currently, very few or no studies are based on the systematic analysis of the HSPs in Glioblastoma (GBMs) and ependymomas. We performed an integrated omics analysis to predict the mutual regulatory differential
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Neonatal oxytocin treatment alters levels of precursor and mature BDNF forms and modifies the expression of neuronal markers in the male rat hippocampus Neuropeptides (IF 2.9) Pub Date : 2023-09-18 Stanislava Bukatova, Alexandra Reichova, Zuzana Bacova, Jan Bakos
Neuropeptide oxytocin appears to be involved in the formation of hippocampal circuitry, underlying social memory and behaviour. Recent studies point to the role of oxytocin in regulating the levels of nerve growth factors that could influence neurogenesis and neuritogenesis during the early stages of brain development. Therefore, the aim of the present study was to evaluate the early developmental
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The regulatory effects of the apelin/APJ system on depression: A prospective therapeutic target Neuropeptides (IF 2.9) Pub Date : 2023-09-11 Yanjun Tian, Ruihao Wang, Lin Liu, Wenhuan Zhang, Haiqing Liu, Liqing Jiang, Yunlu Jiang
Depression is a debilitating neuropsychological disorder characterized by high incidence, high recurrence, high suicide, and high disability rates, which poses serious threats to human health and imposes heavy psychological and economic burdens on family and society. The pathogenesis of depression is extremely complex, and its etiology is multifactorial. Mounting evidence suggests that apelin and apelin
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Mate calling alters expression of neuropeptide, cocaine- and amphetamine- regulated transcript (CART) in the brain of male frog Microhyla nilphamariensis Neuropeptides (IF 2.9) Pub Date : 2023-09-09 Shobha Bhargava, Ketaki Shetye, Swapnil Shewale, Nitin Sawant, Sneha Sagarkar, Nishikant Subhedar
Croaking is a unique component of reproductive behaviour in amphibians which plays a key role in intraspecies communication and mate evaluation. While gonadal hormones are known to induce croaking, central regulation of sound production is less studied. Croaking is a dramatic, transient activity that sets apart an animal from non-croaking individuals. Herein, we aim at examining the profile of the
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Reduced mastication during growth inhibits cognitive function by affecting trigeminal ganglia and modulating Wnt signaling pathway and ARHGAP33 molecular transmission Neuropeptides (IF 2.9) Pub Date : 2023-08-17 Eri Misawa-Omori, Hidemasa Okihara, Takuya Ogawa, Yasunori Abe, Chiho Kato, Hideyuki Ishidori, Akiyo Fujita, Satoshi Kokai, Takashi Ono
Binding of brain-derived neurotrophic factor (BDNF) to its receptor tyrosine kinase B (TrkB) is essential for the development of the hippocampus, which regulates memory and learning. Decreased masticatory stimulation during growth reportedly increases BDNF expression while decreasing TrkB expression in the hippocampus. Increased BDNF expression is associated with Wnt family member 3A (Wnt3a) expression
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An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review Neuropeptides (IF 2.9) Pub Date : 2023-08-12 Sukanya Singh, Mitali Mahajan, Dhawal Kumar, Kunika Singh, Mehvish Chowdhary
Alzheimer's disease (AD) has remained elusive in revealing its pathophysiology and mechanism of development. In this review paper, we attempt to highlight several theories that abound about the exact pathway of AD development. The number of cases worldwide has prompted a constant flow of research to detect high-risk patients, slow the progression of the disease and discover improved methods of treatment
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Bee venom ameliorates oxidative stress and histopathological changes of hippocampus, liver and testis during status epileptics Neuropeptides (IF 2.9) Pub Date : 2023-08-02 Esraa K. Aly, Hanan S. Mahmoud, Dalal H.M. Alkhalifah, Gaber M.G. Shehab, Abdelaziz S.A. Abuelsaad, Eman S. Abdel-Rehiem, Manal Abdul-Hamid
The unrelenting progression of neurodegenerative diseases has a negative impact on affected individuals, their families, and society. Recurrent epileptic seizures are the hallmark of epilepsy, and treating it effectively remains difficult. Clarify and understanding effects of the antiepileptic drugs (AEDs) in epilepsy by comparing the therapeutic effects between rats receiving valproic acid (VPA) and
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FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease Neuropeptides (IF 2.9) Pub Date : 2023-07-22 Arzuhan Cetindag Ciltas, Sebahattin Karabulut, Bilal Sahin, Ahmet Kemal Filiz, Fatih Yulak, Mustafa Ozkaraca, Ozhan Karatas, Ali Cetin
Alzheimer's disease (AD) is a multifactorial pathology marked by amyloid beta (Aβ) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) exerts a neuroprotective effect in experimental models of neurodegeneration; however, how it affects AD pathology remains unknown. This study aimed to ascertain the impact of FGF18
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Effects of voluntary, and forced exercises on neurotrophic factors and cognitive function in animal models of Parkinson's disease Neuropeptides (IF 2.9) Pub Date : 2023-06-26 Forouzan Rafie, Mohammad Amin Rajizadeh, Mehdi Shahbazi, Mohammad Pourranjbar, Amir H. Nekouei, Vahid Sheibani, Daniel Peterson
Background Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. Cognitive dysfunction represents a common and challenging non-motor symptom for people with Parkinson's disease. The number of neurotrophic proteins in the brain is critical in neurodegenerative diseases such as Parkinson's. This research aims to compare the effects of two types of exercise, forced
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Protective effects of Zishen Huoxue recipe against neuronal injury in the neurovascular unit of rats with vascular dementia by interfering with inflammatory cascade-induced pyroptosis Neuropeptides (IF 2.9) Pub Date : 2023-06-26 Ting Yao, Le Xie, Yao Xie, Jinlin Jiang, Qian Deng, Jie Wang, Lu Liu, Dahua Wu
Objective Chinese herbal formulas show considerable therapeutic benefits in dementia. This study specifically explored the protective action of Zishen Huoxue recipe on the neurovascular unit (NVU) of rats with vascular dementia (VD). Methods VD rat models were established by permanent bilateral common carotid artery occlusion and treated with Zishen Huoxue recipe. In vitro glucose‑oxygen deprivation
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Role and therapeutic target of P2X2/3 receptors in visceral pain Neuropeptides (IF 2.9) Pub Date : 2023-06-23 Hong-mei Luo, Jia-rong Ye, Fan-qin Pu, Hong-liang Luo, Wen-jun Zhang
Visceral pain (VP) is caused by internal organ disease. VP is involved in nerve conduction and related signaling molecules, but its specific pathogenesis has not yet been fully elucidated. Currently, there are no effective methods for treating VP. The role of P2X2/3 in VP has progressed. After visceral organs are subjected to noxious stimulation, cells release ATP, activate P2X2/3, enhance the sensitivity
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Neurobiochemical characteristics of arginine-rich peptides explain their potential therapeutic efficacy in neurodegenerative diseases Neuropeptides (IF 2.9) Pub Date : 2023-06-23 Sedigheh Eskandari, Ameneh Rezayof, S. Mohsen Asghari, Shiva Hashemizadeh
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Apelin receptor antagonist (ML221) treatment has a stimulatory effect on the testicular proliferation, antioxidants system and steroidogenesis in adult mice Neuropeptides (IF 2.9) Pub Date : 2023-06-20 Milirani Das, Guruswami Gurusubramanian, Vikas Kumar Roy
The expression of apelin and its receptor (APJ) has been shown in the hypothalamus-pituitary-testicular axis. It has also been suggested apelin and APJ are neuropeptide factors. The presence of apelin and APJ in the seminiferous tubules and interstitium might be predicted to act as a local regulator of testicular activity, although the function is not well known in the mice testis. In the present study
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Oxytocin as neuro-hormone and neuro-regulator exert neuroprotective properties: A mechanistic graphical review Neuropeptides (IF 2.9) Pub Date : 2023-06-16 Roya Kamrani-Sharif, A. Wallace Hayes, Mina Gholami, Mahsa Salehirad, Maryam Allahverdikhani, Majid Motaghinejad, Enzo Emanuele
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Restraint stress potentiates sensitivity to the antinociceptive effect of morphine through orexin receptors in the ventral tegmental area Neuropeptides (IF 2.9) Pub Date : 2023-06-15 Sajad Mazaheri, Morteza Zendehdel, Abbas Haghparast
Orexin signaling in the ventral tegmental area (VTA) plays a critical role in stress and addictive behaviors. On the other hand, exposure to stress potentiates behavioral sensitization to drugs of abuse such as morphine. This study aimed to elucidate the role of orexin receptors within the VTA in restraint stress (RS)-induced morphine sensitization. Adult male albino Wistar rats underwent stereotaxic
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Protective effect of TNIP2 on the inflammatory response of microglia after spinal cord injury in rats Neuropeptides (IF 2.9) Pub Date : 2023-06-12 Jiawei Fu, Chunshuai Wu, Guanhua Xu, Jinlong Zhang, Jiajia Chen, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Jiayi Huang, Chunyan Ji, Zhiming Cui
Background Spinal cord injury (SCI) is a devastating disease that can lead to tissue loss and neurological dysfunction. TNIP2 is a negative regulator of NF-κB signaling due to its capacity to bind A20 and suppress inflammatory cytokines-induced NF-κB activation. However, the anti-inflammatory role of TNIP2 in SCI remains unclear. Our study's intention was to evaluate the effect of TNIP2 on the inflammatory
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Hippocampal pituitary adenylate cyclase–activating polypeptide mediates rapid antidepressant-like effects of Yueju pill Neuropeptides (IF 2.9) Pub Date : 2023-06-01 Li Ren, Hailou Zhang, Weiwei Tao, Wenda Xue, Yin Chen, Zhilu Zou, Xiaoyan Guo, Qinqin Shen, Wei Wang, Haitang Jiang, Juanjuan Tang, Quansheng Feng, Gang Chen
Yueju pill, a classic Chinese Medicine formulated, was recently found to produce rapid antidepressant-like effects in a PKA-CREB signaling-dependent manner. In our study, we found that the Yueju pill induced a remarkable increase in PACAP. The intracerebroventricular injection of PACAP agonist induced a rapid antidepressant-like effect; conversely, the intrahippocampal infusion of a PACAP antagonist
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Protective effect of Prolactin releasing peptide against 1,2-diacetylbenzene -induced neuroinflammation Neuropeptides (IF 2.9) Pub Date : 2023-05-26 Ngoc Minh Hong Hoang, Wonhee Jo, Min-Sun Kim
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Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury Neuropeptides (IF 2.9) Pub Date : 2023-05-19 Zucheng Huang, Junyu Lin, Hui Jiang, Wanrong Lin, Zhiping Huang, Jiayu Chen, Wende Xiao, Qiong Lin, Jun Wang, Shifeng Wen, Qingan Zhu, Junhao Liu
Patients with a spinal cord injury (SCI) usually suffer lifelong disability as a result. Considering this, SCI treatment and pathology study are urgently needed. Metformin, a widely used hypoglycemic drug, has been indicated for its important role in central nervous system diseases. This study aimed to investigate the potential effect of metformin on remyelination after SCI. In the present study, we
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Changes in working memory induced by lipopolysaccharide administration in mice are associated with metabotropic glutamate receptors 5 and contrast with changes induced by cyclooxygenase-2: Involvement of postsynaptic density protein 95 and down syndrome cell adhesion molecule Neuropeptides (IF 2.9) Pub Date : 2023-05-09 Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Magdalena Sowa-Kućma, Paulina Misztak
The strength and quality of the signal propagated by the glutamate synapse (Glu) depend, among other things, on the structure of the postsynaptic part and the quality of adhesion between the interacting components of the synapse. Postsynaptic density protein 95 (PSD95), mammalian target of rapamycin (mTOR), and Down syndrome cell adhesion molecule (DSCAM) are components of the proper functioning of
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Intrathecal administration of botulinum toxin type a antagonizes neuropathic pain by countering increased vesicular nucleotide transporter expression in the spinal cord of chronic constriction injury of the sciatic nerve rats Neuropeptides (IF 2.9) Pub Date : 2023-05-08 Yongqiang Shi, Chaoyang Gong, Wei Nan, Wenming Zhou, Zeyuan Lei, Kaisheng Zhou, Linna Wang, Guanghai Zhao, Haihong Zhang
Botulinum toxin type A (BoNT/A) induces direct analgesic effects in neuropathic pain by inhibiting the release of substance P, calcitonin gene-related peptide (CGRP) and glutamate. Vesicular nucleotide transporter (VNUT) was responsible for the storage and release of ATP in vivo, and one of the mechanisms underlying neuropathic pain is VNUT-dependent release of extracellular ATP from dorsal horn neurons
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Naloxone could limit morphine hypersensitivity: Considering the molecular mechanisms Neuropeptides (IF 2.9) Pub Date : 2023-05-04 Mojgan Baratzadeh, Samira Danialy, Shima Abtin, Homa Manaheji
Background Naloxone has been used as an opioid antagonist to prevent multiple adverse side effects of opioid-like tolerance and hyperalgesia. This study has investigated naloxone combined with morphine to limit pain hypersensitivity. In addition, the expression of brain-derived neurotrophic factor (BDNF) and K+ Cl− cotransporter2 (KCC2) were also studied. Methods Forty-eight adult male Wistar rats
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Arginine vasopressin effects on membrane potentials of preoptic area temperature-sensitive and -insensitive neurons in rat hypothalamic tissue slices Neuropeptides (IF 2.9) Pub Date : 2023-04-27 Yu Tang, Siyuan Liu, Lingzhi Xu, Min Huang, Ke Zhang
Arginine vasopressin (AVP) plays a hypothermic regulatory role in thermoregulation and is an important endogenous mediator in this mechanism. In the preoptic area (POA), AVP increases the spontaneous firing and thermosensitivity of warm-sensitive neurons and decreases those of cold-sensitive and temperature-insensitive neurons. Because POA neurons play a crucial role in precise thermoregulatory responses
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Anandamide improves food intake and orexinergic neuronal activity in the chronic sleep deprivation induction model in rats by modulating the expression of the CB1 receptor in the lateral hypothalamus Neuropeptides (IF 2.9) Pub Date : 2023-04-20 Rafie Belali, Seyyed Ali Mard, Seyed Esmaeil Khoshnam, Kowsar Bavarsad, Alireza Sarkaki, Yaghoob Farbood
Sleep deprivation alters orexinergic neuronal activity in the lateral hypothalamus (LH), which is the main regulator of sleep-wake, arousal, appetite, and energy regulation processes. Cannabinoid receptor (CBR) expression in this area is involved in modulating the function of orexin neurons. In this study, we investigated the effects of endocannabinoid anandamide (AEA) administration on improving food
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Several neuropeptides involved in parkinsonian neuroprotection modulate the firing properties of nigral dopaminergic neurons Neuropeptides (IF 2.9) Pub Date : 2023-04-15 Lei Chen, Cui Liu, Yan Xue, Xin-Yi Chen
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Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy Neuropeptides (IF 2.9) Pub Date : 2023-03-24 Mohammad Sheibani, Maryam Shayan, Mina Khalilzadeh, Mehdi Ghasemi, Ahmad Reza Dehpour
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The role of sensory and sympathetic nerves in craniofacial bone regeneration Neuropeptides (IF 2.9) Pub Date : 2023-02-18 Freshet Assefa
Multiple factors regulate the regeneration of craniofacial bone defects. The nervous system is recognized as one of the critical regulators of bone mass, thereby suggesting a role for neuronal pathways in bone regeneration. However, in the context of craniofacial bone regeneration, little is known about the interplay between the nervous system and craniofacial bone. Sensory and sympathetic nerves interact
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PACAP inhibition alleviates neuropathic pain by modulating Nav1.7 through the MAPK/ERK signaling pathway in a rat model of chronic constriction injury Neuropeptides (IF 2.9) Pub Date : 2023-02-15 Mingzheng Liu, Fan He, Mengci Shao, Tianyuan Li, Liecheng Wang, Yuanyin Wang, Wenhua Xu
Background Trigeminal neuralgia is a common chronic maxillofacial neuropathic pain disorder, and voltage-gated sodium channels (VSGCs) are likely involved in its pathology. Prior studies report that pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide highly expressed in the trigeminal ganglion, may contribute to dorsal root ganglion neuron excitability by modulating the Nav1
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Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain Neuropeptides (IF 2.9) Pub Date : 2023-02-15 Zainab Y. Kareem, Patricia J. McLaughlin, Rashmi Kumari
The opioid growth factor (OGF) is an endogenous peptide that binds to the nuclear-associated receptor (OGFr), and plays a significant role in the proliferation of developing, renewing, and healing tissues. The receptor is widely expressed in a variety of organs, however its distribution in the brain remains unknown. In this study, we investigated the distribution of OGFr in different brain regions
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Interactions between the regulatory peptide 26RFa (QRFP) and insulin in the regulation of glucose homeostasis in two complementary models: The high fat 26RFa-deficient mice and the streptozotocin insulin-deficient mice Neuropeptides (IF 2.9) Pub Date : 2023-02-09 Marie-Anne Le Solliec, Arnaud Arabo, Saloua Takhlidjt, Julie Maucotel, Mélodie Devère, Hind Berrahmoune, Alexandre Bénani, Emmanuelle Nedelec, Benjamin Lefranc, Jérôme Leprince, Marie Picot, Nicolas Chartrel, Gaëtan Prévost
The regulatory peptide 26RFa (QRFP) is involved in the control of glucose homeostasis at the periphery by acting as an incretin, and in the brain by mediating the central antihyperglycemic effect of insulin, indicating the occurrence of a close relationship between 26RFa and insulin in the regulation of glucose metabolism. Here, we investigated the physiological interactions between 26RFa and insulin
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The stress-induced antinociceptive responses to the persistent inflammatory pain involve the orexin receptors in the nucleus accumbens Neuropeptides (IF 2.9) Pub Date : 2023-01-28 Seyed Mohammadmisagh Moteshakereh, Mohammad Nikoohemmat, Danial Farmani, Elahe Khosrowabadi, Sakineh Salehi, Abbas Haghparast
Stress suppresses the sense of pain, a physiological phenomenon known as stress-induced analgesia (SIA). Brain orexin peptides regulate many physiological functions, including wakefulness and nociception. The contribution of the orexinergic system within the nucleus accumbens (NAc) in the modulation of antinociception induced by forced swim stress (FSS) remains unclear. The present study addressed
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Sex-dimorphic hindbrain lactate regulation of ventromedial hypothalamic nucleus glucoregulatory neuron 5’-AMP-activated protein kinase activity and transmitter marker protein expression Neuropeptides (IF 2.9) Pub Date : 2023-02-02 Prabhat R. Napit, Md. Haider Ali, A.S.M. Hasan Mahmood, Mostafa M.H. Ibrahim, Karen P. Briski
Background The oxidizable glycolytic end-product L-lactate is a gauge of nerve cell metabolic fuel stability that metabolic-sensory hindbrain A2 noradrenergic neurons impart to the brain glucose-regulatory network. Current research investigated the premise that hindbrain lactate deficiency exerts sex-specific control of energy sensor and transmitter marker protein responses to hypoglycemia in ventromedial
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Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression Neuropeptides (IF 2.9) Pub Date : 2023-01-20 Muhammad Asim, Huajie Wang, Abdul Waris
Depression is the second leading cause of disability in the world population, for which currently available pharmacological therapies either have poor efficacy or have some adverse effects. Accumulating evidence from clinical and preclinical studies demonstrates that the amygdala is critically implicated in depressive disorders, though the underlying pathogenesis mechanism needs further investigation