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Synthesis of Novel 4‐Acyloxy‐2′‐bromo‐6′‐chloropodophyllotoxin Derivatives Displaying Significant Insecticidal Activity against Mythimna separata Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-25 Zhiping Che, Yuee Tian, Shiyue Ma, Yibo Liu, Yan Li, Genqiang Chen
In order to explore novel natural product‐based insecticidal agent, two important intermediates (2 and 3) and 4‐acyloxy‐2′‐bromo‐6′‐chloropodophyllotoxin derivatives (4a‐f and 5a‐f) were designed and prepared, and their structures were confirmed by 1H NMR, 13C NMR, HRMS, ESI‐MS, optical rotation and melting point (mp). The stereochemical configuration of compound 4b was unambiguously confirmed by single‐crystal
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Baccharoides anthelmintica (L.) Moench: A Review on Ethnomedicinal, Phytochemical, Pharmacological and Toxicological Profile Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-24 Srinivasa Rao Kareti, Vivek Singh Rajpoot
Baccharoides anthelmintica (L.) Moench is a popular medicinal plant with a long history of use in several traditional remedies to cure a variety of diseases including; its effect on the central nervous system, gastrointestinal tract, metabolism, kidneys, gynecology, skin diseases, and general health. The present review aims to provide the latest, organized information on toxicological, pharmacological
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Seasonal and circadian variation of non‐volatile metabolites in Lippia alba leaves. Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-23 Angélica Ferraz Gomes, Girlane Oliveira Rocha, Caroline Scabini, Jayne Ferreira da Silva Oliveira, Déborah Neres Oliveira, Luise Carvalho Mota, Brenda Novais Almeida Neves, Amanda Menezes dos Santos, Urias Santos Araújo, Bruno Oliveira Moreira, Flávio Mendes de Souza, Maiara Prates de Almeida, Juliano Geraldo Amaral, Jorge Maurício David
The present study describes the seasonal and circadian variations of the major compounds from Lippia alba leaves. SPSS was used to identify, quantify, and associate the variations in the secondary metabolites of this species through HPLC/DAD analysis of the leaves hydroethanolic extracts of six selected L. alba specimens. For the circadian study, the samples were collected at four different daily hours
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Exploring Steroidal Saponin Composition and Morphometric Characteristics of Rhizomes from Trillium govanianum Wall. ex D. Don: Inference for Medicinal Properties and Genetic Stock Improvement Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-23 SURENDRA SINGH BISHT, R K Meena, Maneesh Bhandari, Prithvi Pal Singh, Upendra Pal Sharma, Aman Bisht, P K Verma
Trillium govanianum, a medicinal herb, exhibiting diverse morphometric traits and phytochemicals across developmental stages of plants. The changes in the chemical profile and steroidal saponin levels in the rhizome of T. govanianum across different developmental stages were previously unknown. This study categorizes rhizomes into three types based on scar presence: juvenile (5–10 scars, Type I), young
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Oleanane‐Type Triterpene Glycosides from Camellia phanii and Their α‐Glucosidase Inhibitory Activity Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-22 Hoang Thi Tuyet Lan, Vu Thi Xuan, Bui Thi Mai Anh, Nguyen Thi Mai, Nguyen Viet Dung, Bui Huu Tai, Nguyen Thi Minh Hang, Vu Mai Thao, Nguyen Xuan Nhiem
: Three new oleanane‐type triterpene saponins, named camphanosides A–C (1–3), along with five known compounds, chikusetsusaponin IVa (4), spinasaponin A 28‐O‐glucoside (5), (‐)‐epicatechin (6), (‐)‐epicatechin 3‐O‐gallate (7), and (‐)‐epigallocatechin 3‐O‐gallate (8) were isolated from the leaves Camellia phanii Hakoda & Ninh. Their structures were established by 1D and 2D‐NMR and mass spectral analysis
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Comparison of the Secondary Metabolism of the Basidiomycetes Armillaria mellea and Desarmillaria ectypa Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-19 Jacklyne Chepkemoi, Sebastian Pfütze, Njogu M. Kimani, Josphat C Matasyoh, Marc Stadler
During the course of our ongoing studies on the secondary metabolism of cultures of Basidiomycota, a new meroterpenoid named 10, 15-dihydroxydihydromelleolide (1) was isolated along with the known armillaridin (2) and arnamiol (3) from cultures of the rare saprotrophic species, Desarmillaria ectypa. These are the first secondary metabolites that were ever isolated from the latter species. A concurrently
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A new insight into the Huisgen reaction: Heterogeneous Copper catalyzed azide-alkyne cycloaddition for the synthesis of 1,4-disubstitutedtriazole (from 2018-2023) Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-19 Shivani Kasana, Vaibhav Nigam, Surbhi Singh, BALAK Das KURMI, Preeti Patel
The Huisgen cycloaddition, often referred to as 1,3-Dipolar cycloaddition, is a well-established method for synthesizing 1,4-disubstituted triazoles. Originally conducted under thermal conditions [3+2] cycloaddition reactions were limited by temperature, prolonged reaction time, and regioselectivity. The copper catalyzed azide-alkyne cycloaddition (CuAAC) has emerged as a prominent method for producing
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Nervogenic Acid Derivatives and Phenanthrenes from Liparis nervosa and Their Antimicrobial and Immunosuppressive Activities Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-19 Hong Jiang, Yang Liu, Bo Ren, Yi Lai, Hu-Lan Chen, Li-Mei Li
Two new nervogenic acid derivatives liparisnervosides Q (1) and R (5), as well as five known nervogenic acid derivatives (2−4, 6, 7) and four phenanthrenes (8−11) were isolated from the whole plant of Liparis nervosa (Thunb. ex A. Murray) Lindl.. Their structures were detremined using extensive spectroscopic techniques, including 1D, 2D NMR, and HR-ESI-MS, and acid hydrolysis. Furthermore, their antimicrobial
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WITHANICANDRIN ISOLATED FROM Datura Ferox PROMOTES ANTINOCICEPTION BY MODULATING THE ASICS AND TRPS CHANNELS AND ANTI‐INFLAMMATION IN ADULT ZEBRAFISH Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-19 Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, João Pedro Vieira da Silva, Francisco das Chagas L. Pinto, Emanuela de Lima Rebouças, Francisco Sydney Henrique da Silva, Maria Kuerislene Amâncio Ferreira, Marcia Machado Marinho, Emmanuel Silva Marinho, Otília Deusdênia Loiola Pessoa, Paulo Goberlânio de Barros Silva, Andrelina Noronha Coelho de-Souza, Maria Izabel Florindo
This is the first study to analyze the anti‐inflammatory and antinociceptive effect of withanicandrin, isolated from Datura Ferox leaves, and the possible mechanism of action involved in adult zebrafish (ZFa). To this end, the animals were treated intraperitoneally (i.p.) with withanicandrin (4; 20 and 40 mg/kg; 20 μL) and subjected to locomotor activity and acute toxicity. Nociception tests were also
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Synthesis of some novel 1H-phenanthro [9,10-d]imidazole derivatives and their Antibacterial and Molecular docking investigation Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-18 Nosrat O Mahmoodi, anahita Rajabi, Hadiseh Yazdani Nyaki, Hossein Taherpour Nahzomi
In this study, several imidazole derivatives in one pot multicomponent reaction from various aldehydes (1(a-z)), 9,10-phenanthrenequinone, or benzyl (2), and ammonium acetate (3) were synthesized in the presence of acetic acid (AcOH) under reflux conditions at 120°C. Also, the photochromic properties of synthesized compounds were investigated in AcOH as a solvent under laboratory conditions at a temperature
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Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti-monoamine Oxidase Activity Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-18 Chengcheng Hui, Shuaibo He, Mengshan Ji, Yuhang Zhang, Haibo Wang, Xiaowei Wang, Tao guo
Baihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect
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Phytochemical Composition, Antioxidant and Antimicrobial Activity of Three Monarda Species: M. bradburiana L. C. Beck, M. × media Willd., and M. punctata L. Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-18 Łukasz Gontar, Anna Geszprych, Andżelika Drutowska, Ewa Osińska
Plants of the genus Monarda receive growing interest as the sources of herbal raw materials with wide range of potential applications in food, cosmetics, and phytopharmaceutical industry. This study aimed to evaluate the differences in chemical characteristics and biological activity among different organs of plants representing three underinvestigated species of this genus: Monarda bradburiana L.
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Flavonoids from the Aerial Parts of Sophora tonkinensis and Their Potential Anti-inflammatory Activities Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-18 Qing-Qing Yang, Yan-Fei Yang, Xuan-Qin Chen, Rong-Tao Li, Zhi-Jun Zhang
Four undescribed prenylated flavonoids, sophoratones A–D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide
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Synergistic Inhibitions of Gram-negative Bacteria by Combination Treatment with Ciprofloxacin and a Novel Glucolipid Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-17 Liyuan Yang, Qingqing Zhang, Deng Yu, Weiming Zhu, Yi Wang
Abstract: Psychrophilic fungus Pseudogymnoascus sp. OUCMDZ-4032 derived from Antarctica was cultivated under 16 ℃ to produce a new glucolipid compound (1). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization, and 13C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against
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BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-17 Amanda Tristao Santini, Rayra Annara Otacílio Pinto, Josy Goldoni Lazarini, Daniel Vieira de Morais, Anna Maria Alves de Piloto Fernandes, Marcelo Franchin, Patricia Lunardelli Negreiros de Carvalho, Carolina Girotto Pressete, Pedro Luiz Rosalen, Severino Matias de Alencar, Patricia de Oliveira Carvalho, Marisa Ionta, Masaharu Ikegaki
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity
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Further polycyclic quinones of Micromonospora sp. Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-16 Otilia Deusdenia Loiola Pessoa, Hozana Patricia Silva de Freitas Cesário, Francisco das Chagas Lima Pinto, Kirley Marques Canuto, Ediberto Rocha Silveira, Diego Veras Wilke, Elthon Gois Ferreira, Aluísio Marques da Fonseca, Mayron Alves de Vasconcelos, Edson Holanda Teixeira
The crude acetone extract of a marine Micromonospora sp. strain associated with Eudistoma vannnamei was fractioned with hexane and ethyl acetate. The crude extract and both soluble fractions were assayed against several bacteria strains. The new polycyclic quinones 12-hydroxy-9-propyltetracene-6,1-dione (1), 5,12-dihydroxy-4-methoxy-9-propyltetracene-5,12-dione (2), and 4,6-dihydroxy-3-methoxycarbonyl-
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Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia umbellata Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-16 Amanda Santos Gusmão, João Carlos Silva Conceição, Stefane Moreira de Queiros Santos, Cecilia Lima Sampaio Pereira, Douglas Siqueira de Almeida Chaves, Karen de Jesus Nicácio, Daniela Aparecida Chagas-Paula, Eliane Oliveira Silva
Endophytic fungi live asymptomatically inside vegetal tissues, and such uncommon habitat contributes to their exceptional chemical diversity. Isolating natural products from endophytic fungi could fail due to silent biosynthetic gene clusters under ordinary in vitro culture conditions, and co‐culturing has been assayed to trigger their metabolism. We carried out single and dual cultures with 13 endophyte
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Computational Exploration of Naturally Occurring Flavonoids as TGF‐β Inhibitors in Breast Cancer: Insights from Docking and Molecular Dynamics Simulations and In‐vitro Cytotoxicity Study Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-16 UMANG SHAH, Niyati Patel, Mehul Patel, Shishir Rohit, Nilay Solanki, Ashish Patel, Swayamprakash Patel, Vishwa Patel, Rajvi Patel, Rahul D Jawarkar
Breast cancer is a global health concern, demanding innovative treatments. Targeting the Transforming Growth Factor‐beta (TGF‐β) signaling pathway, pivotal in breast cancer, is a promising approach. TGF‐β inhibits proliferation via G1 phase cell cycle arrest, acting as a suppressor initially, but in later stages, it promotes progression by enhancing motility, invasiveness, and metastasis formation
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Unveiling The Biomedical Applications Of Novel Coumarins Isolated From Capsicum Annuum L. Seeds By A Multivariate Extraction Technique Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-15 Areej Hazem Fakri Younes, Yasser Fakri Mustafa
For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet
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Ring‐contracted Artemisinin Derivatives as Novel CDK4/6 Inhibitors: Synthesis and Anti‐Breast Cancer Evaluation Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-15 junjie Zhu, yi Ai, junhui Wu, changgaung Zeng, zhen Cui, zhengping Zhang, jiayi Zhu, changqi Wang, hang Zhong
The endoperoxide group of artemisinins is a universally accepted essential group for their anti‐cancer effects. In this work, a series of D‐ring‐contracted artemisinin derivatives were constructed by combining ring‐contracted artemisinin core with the fragments of functional heterocyclic molecules or classical CDK4/6 inhibitors to identify more efficacious breast cancer treatment agents. Twenty‐six
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Porphysome Engineered With Specific Protein Binding Sites as a Multimodal Theranostic Nanocarrier for Targeted Protein Delivery Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-15 Niloofar Ayyari, Zahra Vaezi, Zeinab Fotouhi Ashin, Elham Karimi, Fatemeh Mohsenzadeh haji, Maryam Nikkhah, Hossein Naderi-Manesh
The immobilization of proteins on the surface of carriers is challenging due to the loss of protein structure and function in this process. Here, we report the development of the protein immobilization on the surface of the metallated‐porphyrin complex in the porphysome nanocarrier. The conjugated Ni‐porphyrin to fatty acid (as a tail) has been synthesized and independently placed at the depth of the
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Synthesis and Antifungal Activity of Norbornene Carboxamide/sulfonamide Derivatives as Potential Fungicides Targeting Laccase Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-15 Zi-Hui Yang, Yi-Gui Qiu, Dao-Jun Jin, Yi-Ming Zheng, Jia Li, Wen Gu
To explore more potential fungicides with new scaffolds, thirty‐seven norbornene carboxamide/sulfonamide derivatives were designed, synthesized, and assayed for inhibitory activity against six plant pathogenic fungi and oomycetes. The preliminary antifungal assay suggested that the title derivatives showed moderate to good antifungal activity against six plant pathogens. Especially, compound 6e presented
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Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-13 Abdelfatah Aitbaba, Hamid Kabdy, Abdelmounaim Baslam, Hajar Azraida, Rachida Aboufatima, Loubna El Yazouli, Zahra Sokar, Stefania Garzoli, Abderrahman Chait
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Determination of Bacterial Community Structure of Table Olive via Metagenomic Approach in Şarköy Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-13 SAMET UÇAK
One of the most popular pickled foods created worldwide is table olives. The aim was to identify the bacterial microbiota of table olive samples collected from Şarköy, Tekirdağ‐Türkiye using next generation sequencing and 16S metagenomic analysis. Samples were studied as non‐pre‐enriched (n:10) and after pre‐enrichment (n:10) to compare the effects of the enrichment process on the bacterial diversity
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Retrobisabolane A, a Novel Bisabolane‐Derived Sesquiterpenoid Isolated from Deep‐Sea‐Derived Fungus Retroconis fusiformis MCCC 3A00792 Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-13 Xin Liu, Yinghui Lv, Jianlin He, Bihong Hong, Zongze Shao, Miao Yu, Siwen Niu
One novel bisabolane‐derived sesquiterpenoid retrobisabolane A (1), featuring a methyl group location at the C‐4 position instead of C‐3 in the bisabolanes, and a known ester‐substituted eremophilane‐type sesquiterpenoid cryptosphaerolide (2), along with three known indole alkaloids (3‒5) were discovered from the fermented cultures of a deep‐sea‐derived fungus Retroconis fusiformis MCCC 3A00792. The
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Investigations of Limeum indicum Plant for Diabetes Mellitus and Alzheimer’s disease Dual Therapy: Phytochemical, GC‐MS Chemical Profiling, Enzyme Inhibition, Molecular Docking and In‐vivo Studies Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Tahira Shamim, Hafiz Muhammad Asif, Syeda Abida Ejaz, Zahid Hussain, Tanveer A. Wani, Laila Sumreen, Muhammad Abdullah, Zubair Ahmed, Jamshed Iqbal, Song Ja Kim, Muhammad Kamal Shah
Limeum indicum has been widely utilized in traditional medicine but no experimental work has been done on this herb. The primary objective of this study was to conduct a phytochemical analysis and assess the multifunctional capabilities of aforementioned plant in dual therapy for Alzheimer's disease (AD) and Type 2 diabetes (T2D). The phytochemical screening of ethanol, methanol extract, and their
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Design, Synthesis, Docking Studies and Molecular Dynamics Simulation of New 1,3,5‐Triazine Derivatives as Anticancer Agents Selectively Targeting Pancreatic Adenocarcinoma (Capan‐1) Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Shazia Asghar, Shahid Hameed, Najim A Al‐Masoudi, Bahjat Saeed, Amneh Shtaiwi
On the basis of remarkable anticancer profile of s‐triazine nucleus, a new series of 2‐methoxy‐4‐(3‐morpholino‐5‐(arylamino)phenoxy)benzaldehyde derivatives 11 a–u was prepared and evaluated for in vitro antiproliferative activity against eight diverse human cancer cell lines (Capan‐1, HCT‐116, LN229, NCI‐H460, DND‐41, HL‐60, K562 and Z138). Compounds 11 o, 11 r and 11 s were the most potent anticancer
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Protective Effects of Tunisian Orange Co‐Product Extract and Oleuropein‐Hesperidin Combination on Bleomycin‐Induced Pulmonary Fibrosis in Rats Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Mariem BEN ABDALLAH, Sana BAHRI, NAHDI Afef, MLIKA Mona, HADJKACEM Linda, JAMELEDDINE Saloua, BOUDHRIOUA Nourhene
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia with acute lung damage leading to the deterioration of lung function and increased mortality risk. In this study, we aimed to investigate the effects of the orange coproduct extract (OCE) and the combination of pure hesperidin and oleuropein (HO) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM). Wistar
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New Antibacterial 1, 3, 4‐Thiadiazole Derivatives With Pyridine Moiety Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Nesrin ŞENER, Aiman Emhemad Omeran ALDWIB
1,3,4‐Thiadiazole compounds were synthesized using pyridine carboxylic acid derivatives and thiosemicarbazide derivatives. The molecular structures of the resulting compounds were characterized by spectroscopic methods such as ATR‐FTIR, 1H‐NMR, and elemental analysis. Its compounds were also examined for their antibacterial properties against some strains of bacteria. Five synthesized compounds showed
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Active Constituents with Tyrosinase Inhibitory Activities from Waste Tobacco leaves Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Shu Zhen Mu, Mei Zhang, Jia-Yu Sun, Hong-Mao Qiu, Peng Zhang, Lu-Lu Deng, Jiang Li, Xiao-Jiang Hao, Xian-Kun Su
One novel compound, (R)‐3, 6‐diethoxy‐4‐hydroxycyclohex‐3‐en‐1‐one (1) and thirteen known compounds was isolated from the waste leaves of Nicotiana tabacum. The structures of three compounds (1−3) were confirmed and attributed firstly by the extensive spectroscopic data, including 1D/2D NMR, IR, HR‐ESI‐MS, CD, and ECD spectra. Notably, seven compounds (2, 3, 9, 10, 11, 12, and 13) exhibited better
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CYTOTOXICITY AND BIOLOGICAL ACTIVITIES OF GEOPOPOLIS EXTRACT FROM THE STINGLESS BEE (Melipona scutellaris) IN CLINICAL ISOLATES OF Staphylococcus aureus Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Maria Gabriella Borges, Luanna Lima, Ana Caroline Veras, Rafael Ferreira, Danielle Alves, Isac Medeiros, Marciane Magnani, Marianna Sobral, Ricardo Castro, Saulo Tintino, Cicera Oliveira-Tintino, Henrique Coutinho, Felipe Guerra, Daniela Barros, Maria Betânia Oliveira
This work aims to evaluate the biological activities of the EEGP, in order to contribute with a natural therapeutic alternative, to face infections. The EEGP MIC tests showed antibacterial activity against two strains of S. aureus (LPM 63 and LPM 86), both at concentrations of 550 µg/mL. The MBC performed with the inhibition values showed that the EEGP has bacteriostatic activity in both strains. Biofilm
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Chemical Constituents from the deep‐sea‐derived Fungus Aureobasidium melanogenum LUO5 Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-12 Hao‐Yu Dong, Yuan Wang, Xiao‐Yu Zhang, Meng Zhang, Long‐He Yang, Zheng‐Biao Zou, You Li, Ming‐Min Xie, Xian‐Wen Yang, Bin Wang
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Diaporchalasins A−E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-11 Li Yang, Qi Wang, Qing-Yun Ma, Qing-Yi Xie, Cui-Juan Gai, You-Gen Wu, Hao-Fu Dai, Zhao Youxing
Five new cytochalasins, diaporchalasins A−E (1−5), together with 14 known congeners (6−19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high‐resolution electron spray ionization mass spectrometry (HRESIMS) and nuclear magnetic
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Sulfated Polysaccharides with Anticoagulant Potential: A Review Focusing on Structure‐Activity Relationship and Action Mechanism Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-11 Qianfeng Chen, Mengjiao Zhang, Yue Liu, Wei Liu, Cheng Peng, Lixue Zheng
Thromboembolism is the culprit of cardiovascular diseases, leading to the highest global mortality rate. Anticoagulation emerges as the primary approach for managing thrombotic conditions. Notably, sulfated polysaccharides exhibit favorable anticoagulant efficacy with reduced side effects. This review focuses on the structure‐anticoagulant activity relationship of sulfated polysaccharides and the underlying
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Design, Synthesis, and Biological Evaluation of Novel Quinazoline Derivatives Possessing a Trifluoromethyl Moiety as Potential Antitumor Agents Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-11 Mingxiu Chen, Sha Cheng, Xing Dai, Jia Yu, HuiDi Wang, BiXue Xu, Heng Luo, Guangcan Xu
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Industrial Distillation Fractions of Garlic Essential Oil, Design, Synthesis, and Antifungal Activity Evaluation of Aliphatic Substituted Trisulfide Derivatives Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-11 Yao Chen, Hui Wang, Haiyang Wang, Jie Gao, Yamin Huang, Yu Zhang, Xianhai Lv
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Revealing the 1H NMR Profiling of Six Edible Mushrooms Consumed in the Northeastern Highlands of Puebla, Mexico Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-10 Yesenia Pacheco-Hernández, Nemesio Villa-Ruano, Edmundo Lozoya-Gloria, Estafania de Jesus Terán-Sánchez, Elvia Becerra-Martínez
The 1H NMR metabolomics profiling of six edible mushrooms consumed in the northeastern highlands of Puebla, Mexico is presented. These fungi were morpho‐ and molecularly identified as Infundibulicybe squamulosa, Amanita jacksonii, Lepista nuda, Russula delica, Russula brevipes, and Lactarius indigo. The chemical profiling confirmed the presence of eight essential amino acids and their derivatives,
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Microalgae Octapeptide IIAVEAGC Alleviates Oxidative Stress and Neurotoxicity in 6‐OHDA‐Induced SH‐SY5Y Cells by Regulating the Nrf2/HO‐1 and Jak2/Stat3 Pathways Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-10 Yi Liu, Liyuan Lin, Haiyan Zheng, Huixue Huang, Zhong-Ji Qian
Neurodegenerative diseases are characterized by the progressive loss of selectively vulnerable populations of neurons, and many factors are involved in its causes. Neurotoxicity and oxidative stress, are the main related factors. The octapeptide Ile‐Ile‐Ala‐Val‐Glu‐Ala‐Gly‐Cys (IEC) was identified from the microalgae Isochrysis zhanjiangensis and exhibited potential anti‐oxidative stress activity.
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Design, Synthesis and Biological Evaluation of Novel Gypsogenin Derivatives as Potential Anticancer and Antimicrobial Agents Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-10 Safiye Emirdağ, Nafia Gökce Ulusoy, Mehran Aksel
Natural compounds are important sources for the treatment of chronic disorders such as cancer and microbial infectious disorders. In this research, Gypsogenin and its derivatives (2a‐2f) have been tested against different cancer cell lines (MCF‐7, HeLa, Jurkat and K562 cell lines) and further analyzed for cell proliferation, cell death type, and for act of the mechanism. Cell proliferation was determined
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Front Cover: Synthesis and Antiallodynic Activity of Cannabidiol Analogue on Peripheral Neuropathy in Mice (Chem. Biodiversity 4/2024) Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-10 Gabriel V. L. Marques, Alysson V. Braga, Iara R. Silva, Adna R. B. de Souza, Markus Kohlhoff, Isabela C. César, Renes R. Machado, Renata B. Oliveira
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Four Undescribed Stilbenoid Derivatives from the Aerial Parts of Dendrobium officinale with Their α‐Glucosidase and α‐Amylase Inhibitory Activity Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-09 Pham Hai Yen, Dan Thi Thuy Hang, Bui Huu Tai, Nguyen Thi Cuc, Phan Thi Thanh Huong, Duong Thi Dung, Do Thi Trang, Nguyen Van Hung, Tran Van Hieu, Pham Vam Cuong, Vu Dinh Hoang, Phan Van Kiem
In this study, four undescribed bibenzyl derivatives (1–4), together with seven known compounds (5–11) were isolated from the aerial parts of Dendrobium officinale. Their chemical structures were determined to be (7’S,8’S) ‐9′′‐acetyldendrocandin U (1), (7’S,8’S) ‐4′‐methoxydendrocandin T (2), (7’R,8’S) ‐dendrocandin B (3), (1S,2R) ‐5′′′‐methoxydendrofindlaphenol C (4) by analyzing of the spectroscopic
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Chitosan and Chitooligosaccharides: Antifungal Potential and Structural Insights Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-09 Mayara Itala Geronimo de Azevedo, Pedro Filho Noronha de Souza, José Edvar Monteiro Júnior, Thalles Barbosa Grangeiro
Chitosan is a cationic polysaccharide derived from chitin deacetylation. This polysaccharide and its oligosaccharides have many biological activities and can be used in several fields due to their favorable characteristics, such as biodegradability, biocompatibility, and non‐toxicity. This review explores the antifungal potential of chitosan and chitooligosaccharides and the conditions needed for their
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Synthesis and antifungal activity of coumarin derivatives containing hydrazone moiety Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-09 Zibo Zhang, Dongxian Geng, Zhou Yang, Le Pan, Lu Jin
Plant disease control mainly relies on pesticides. In this study, a series of coumarin derivatives containing hydrazone moiety were designed and synthesized. The synthesized compounds were characterized and used to evaluate the antifungal activity against four pathogens, Botrytis cinerea, Alternaria solani, Fusarium oxysporum, and Alternaria alternata. The results showed that the inhibition rate of
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Transforming Pharmaceutical Synthesis with Sein‐E‐B Nanocomposite Photocatalyst through 1,4‐NAD(P)H Cofactor Regeneration and C‐N Bond Activation Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-09 Ravindra Shukla, Rajesh Yadav, vitthal Gole, Rajat Singhal, Rehana Shahin, Shaifali Mishra, Satyam Singh, Kanchan Sharma, Jin-Ook Baeg, Gamal El-Hiti, Krishna Yadav, Navneet Kumar Gupta
The need for sunlight chemical renewal and contemporary organic transformation has fostered the advancement of environmentally friendly photocatalytic techniques. For the first time, we report on the novel crafting of a bright future with selenium‐infused Eosin‐B (Sein‐E‐B) nanocomposite photocatalysts in this work. The Sein‐E‐B nanocomposite materials were created using a hydrothermal process for
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Nα‐aroyl‐N‐aryl‐phenylalanine amides: a promising class of antimycobacterial agents targeting the RNA polymerase Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-08 Rüdiger W. Seidel, Richard Goddard, Markus Lang, Adrian Richter
Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, remains the leading cause of death from a bacterium in the world. The global prevalence of clinically relevant infections with opportunistically pathogenic non‐tuberculous mycobacteria (NTM) have also been on the rise. Pharmacological treatment of both TB and NTM infections usually requires prolonged regimens of drug combinations, and
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Plant‐Derived Coumarins: A Narrative Review Of Their Structural And Biomedical Diversity Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-08 Areej Hazem Younes, Yasser Fakri Mustafa
Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may
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Advances and Strategies towards Synthesis of Aspidosperma Indole Alkaloids Goniomitine Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-08 Cong-Bin Ji
Goniomitine is of the aspidosperma alkaloid family, with an angularly fused tetracyclic skeleton housing an all‐carbon quaternary carbon chiral center alongside an aminal functional group. This natural product has garnered attention as a synthetic target due to its intriguing molecular architecture and anti‐proliferative activity in recent years. Following the first synthesis of (‐)‐goniomitine by
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Modified Citrus Pectin (MCP) Confers a Renoprotective Effect on Early‐Stage Nephropathy in Type‐2 Diabetic Mice Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-08 Hager M Mahmoud, Abdel-Razik H Abdel-Razik, Mahmoud A Elrehany, Eman M. Othman, Amany A. Bekhit
Diabetic nephropathy (DN) is a significant global health concern with a high morbidity rate. Accumulating evidence reveals that Galectin‐3 (Gal‐3), a β‐galactoside‐binding lectin, is a biomarker in kidney diseases. Our study aimed to assess the advantageous impacts of modified citrus pectin (MCP) as an alternative therapeutic strategy for the initial and ongoing progression of DN in mice with type
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Phytochemical Profile, Antioxidant, Enzyme Inhibition, Acute Toxicity, In Silico Molecular Docking and Dynamic Analysis of Apis mellifera Propolis as Antidiabetic Supplement Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-08 Putri Hawa Syaifie, Delfritama Ibadillah, Muhammad Miftah Jauhar, Rikania Reninta, Sri ningsih, Donny Ramadhan, Adzani Gaisani Arda, Dhecella Winy Cintya Ningrum, Nofa Mardia Ningsih Kaswati, Nurul Taufiqu Rochman, Etik Mardliyati
This study aims to identification of phytochemical profile of Apis mellifera propolis and explore potential of its anti‐diabetic activity through inhibition on α‐amylase (α‐AE), α‐glucosidase(α‐GE) and finally identified the novel antidiabetic compounds from propolis. Apis mellifera propolis extract (AMPE) exhibited elevated polyphenol 33.26 ± 0.17 (mg GAE/g) and flavonoid (15.45 ± 0.13 mg RE/g), while
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Phyto‐fabrication of Moringa oleifera peel‐sourced silver nanoparticles: A promising approach for combating hepatic cancer by targeting proinflammatory cytokines and mitigating cytokine storms Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-08 Shahnawaz Sameem, Vivek Dwivedi, Vikas Kumar, Ashish R. Dwivedi, Prateek Pathak, Bhupendra Singh, Mashooq Ahmad Bhat, Amita Verma
Hepatocellular carcinoma (HCC) arises from precancerous nodules, leading to liver damage and inflammation, which triggers the release of proinflammatory cytokines. Dysregulation of these cytokines can escalate into a cytokine storm, causing severe organ damage. Interestingly, Moringa oleifera (M. oleifera) fruit peel, previously discarded as waste, contains an abundance of essential biomolecules and
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Carane‐3,4‐diol Derivatives as Potential Water‐Based Herbicides Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-06 Yanqun Huang, Maomao Zhu, Hongyun Lan, Daozhan Huang, Mengna Lan, Yanning Huang
Twelve novel carane‐3,4‐diol derivatives were designed, synthesized, and evaluated for their herbicidal activities against Lolium multiflorum Lam. and Brassica campestris for the first time. The relationships between the chemical structural factors, including types, the number or the carbon chain length of functional groups, associated with the lipophilicity and the herbicidal activity of the tested
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Identifying anti‐NSCLC bioactive compounds in Scutellaria via 2D NMR‐based metabolomic analysis of pharmacologically classified crude extracts Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-06 Jialuo Chen, Yanping Li, Xiu Gu, Tianren Wu, Huan Du, Caihong Bai, Jiahui Yang, Kaifeng Hu
We presented a strategy utilizing 2D NMR‐based metabolomic analysis of crude extracts, categorized by different pharmacological activities, to rapidly identify the primary bioactive components of TCM. It was applied to identify the potential bioactive components from Scutellaria crude extracts that exhibit anti‐non‐small cell lung cancer (anti‐NSCLC) activity. Four Scutellaria species were chosen as
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Bio‐guided Isolation of Alpha‐glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella montagnei Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-06 Thuc Huy Duong, Huong Thuy Le, Y Thien Vu, Gia-Huy Duong, Thi-Kim-Dung Le, Minh-Khai Dang, Duc-Dung Pham, Nguyen-Kim-Tuyen Pham, Jirapast Sichaem, Ngoc-Hong Nguyen
A bio‐guided isolation was applied to the Vietnamese lichen Roccella montagnei based on alpha‐glucosidase inhibition. Six compounds were isolated and structurally elucidated, including a new ortho depside, montagneside A (1), together with five known compounds, sekikaic acid (2), lanost‐7‐en‐3β‐ol (3), ethyl orsellinate (4), D‐montagnetol (5), and D‐erythrin (6). Their chemical structures were identified
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Construction and docking studies of novel pyrimido[4,5-b]quinolines as antimicrobial agents Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-03 rania bakr, Islam Helmy, nadia Elkanzi
In order to develop novel antimicrobial agents, we prepared quinoline bearing pyrimidine analogues 2-7, 8a-d and 9a-d and their structures were elucidated by spectroscopic techniques. Furthermore, our second aim was to predict the interactions between the active compounds and enzymes (DNA gyrase and DHFR). In this work, fourteen pyrimido[4,5-b]quinoline derivatives were prepared and assessed for their
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An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-05 Anirudh Pratap Singh Raman, Gauri Thakur, Garima Pandey, Kamlesh Kumari, PRASHANT SINGH
Numerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and the environment. Accurately quantifying pesticide residues is essential for risk evaluation and regulatory purposes. Numerous analytical methods have been developed and utilized to achieve sensitive and specific detection of pesticides in intricate samples like water
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A Review on Ethnobotany, Phytochemistry and Pharmacological activities of Euphorbia antiquorum L. Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-05 Lunasmrita Saikia, Jyotirmoy Bhattacharyya, Saikat Sen, Partha Pratim Dutta
Euphorbia antiquorum L. is a small plant in the Euphorbiaceae family that is found primarily in tropical and subtropical Asia. It has a long tradition of being utilized in Chinese, Ayurvedic, and other traditional systems for a variety of ailments. To date, More than 116 bioactive constituents were isolated from Euphorbia antiquorum, with diterpenoids being the most abundant. Extracts and isolated
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Anti‐inflammatory steroids from the South China Sea Sponge Spongia officinalis Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-05 Yue-Wei Guo, Hai-Yan Zhang, Song-Wei Li, Jiao Liu, Zi-Yi Liu, Yan Fu, Yu-Cheng Gu
One new highly degraded steroid, namely 21‐nor‐4‐ene‐chaxine A (1) furnishing a 5/6/5‐tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT‐ECD calculation, and comparison with the spectral data previously reported in
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Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-05 Vagif Farzaliyev, Adem Ertük, Malahat Abbasova, Oruj Nabiyev, Yeliz Demir, Hatice Kızıltaş, Afsun Sujayev, ilhami Gülçin
1,3‐Diheterocycloalkanes derivatives are important starting materials in fine organic synthesis. These compounds can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. The paper is focused on synthesis and study of alkoxymethyl derivatives of diheterocycloalkanes (M1‐M15) and inhibition effect on carbonic anhydrase and acetylcholinesterase. The structures
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Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism insights Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-04 Naoual El Menyiy, Youssef Elouafy, Rania Moubachir, Rhizlan Abdnim, Taoufiq Benali, Douae Taha, Asaad Khalid, Ashraf N. Abdalla, Siddiqa M.A. Hamza, Salma Elhadi Ibrahim, Mohamed El-Shazly, Gokhan Zengin, Abdelhakim Bouyahya
Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive
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Extraction of Lentinus Edodes Polysaccharides with Ultrasound Enhanced with Deep Eutectic Solvent and Their Structural Characterization and Antioxidant Activity Chem. Biodivers. (IF 2.9) Pub Date : 2024-04-04 Jixian Zhang, Xinglin Zeng, Guoyan Liu, Chaoting Wen, Xin Xu