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Quantum Dots in Cancer Theranostics: A Thorough Review of Recent Advancements in Bioimaging, Tracking, and Therapy across Various Cancer Types Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-22 Amir Matini, Seyed Morteza Naghib, M. R. Mozafari
: Quantum dots (QDs) have attracted considerable interest due to their potential applications and economic viability in various industrial sectors, such as communications, displays, and solar cells. This fascination originates from the quantum size effect-induced remarkable optical properties exhibited by QDs. In recent years, significant progress has been made in producing QDs devoid of cadmium, known
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Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-19 Sagar Das, Tuhin Mukherjee, Satyajit Mohanty, Nikita Nayak, Payel Mal, Sumel Ashique, Radheshyam Pal, Sourav Mohanto, Himanshu Sharma
: This detailed review disclosed the NF-κB pro-inflammatory gen's activity regulation and explored the therapeutic significance, activation, and inhibition. This study uncovers the structural intricacies of the NF-κB proteins and highlights the key role of SIRT1 in NF-kB signaling pathway regulation. Particularly the Rel Homology Domain (RHD), elucidating interactions and the regulatory mechanisms
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Nanogels as Drug Delivery Carrier: A Narrative Review on Formulation Techniques, Characterization, Applications, and Patents Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-19 Alpana Kumari, Kamini Bhardwaj, Supriya Mishra, Lubhan Singh, Faheem Hyder Pottoo, Mohd Yasir
: Under the umbrella of targeted drug delivery systems, several techniques are unleashed in the market that allow a drug or other pharmacologically active material to be delivered to the target cell to treat a condition or health problem. The improvement of the pharmaceutical delivery systems' effectiveness, safety, and stability is accomplished through the Formulation of the nano-gel-based delivery
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A Novel Approach of Polyvinyl Alcohol/Acrylic Acid Based Hydrogels for Controlled Delivery of Diclofenac Sodium Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-16 Muhammad Suhail, Syed Faisal Badshah, I-Hui Chiu, Arif Ullah, Arshad Khan, Hamid Ullah, Noorah Saleh Al-Sowayan, Ming-Jun Tsai, Pao-Chu Wu
Aim and Objective:: The aim of this study was to prepare polyvinyl alcohol/acrylic acid (PVA/AA) hydrogels for the controlled release of diclofenac sodium and to develop PVA/AA hydrogels as controlled release carriers to overcome not only the side effects of diclofenac sodium but also sustain its release for an extended period. Background:: Diclofenac sodium is employed for relieving pain and fever
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Nanodelivery Approaches of Phytoactives for Skin Cancers: Current and Future Perspectives Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-15 Evren Algın Yapar, Merve Nur Özdemir, Meltem Ezgi Durgun, Özlem Akbal Dağıstan, Simona Cavalu, Yıldız Özsoy, Murat Kartal
: In recent years, there has been an increase in skin cancers due to external factors, especially environmental factors, and studies on treatment alternatives have gained importance. Nanomaterials are common, from sunscreen formulas to formulations designed to treat skin cancers at various stages. Using bioactives has multiple effects in treating skin cancers, which provides many advantages. In this
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SiRNA-Mediated Knockdown of ABCB1 Enhances the Efficacy of Doxorubicin and Vinorelbine in Breast Cancer Cells Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-15 Zahra Abbasfard, Abbas Behzad-Behbahani, Banafshe Rastegari, Sirous Naeimi, Mehdi Moghanibashi, Fatemeh Safari
Background: Breast cancer remains a leading cause of cancer-related deaths among women, primarily attributed to the formidable challenge of multidrug resistance, often driven by the overexpression of the ABCB1 gene. background: Breast cancer remains a leading cause of cancer-related deaths among women, primarily attributed to the formidable challenge of multidrug resistance, often driven by the overexpression
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Role of Phytoactive-based Nanoformulation for the Treatment of Arthritis Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-13 Shivendra Kumar, Kantrol Kumar Sahu, Mohit Agrawal, Kuldeep Singh, Sunam Saha
: Joints and arthritic conditions are among the most dangerous illnesses that humans have ever encountered and it is even more worrying that there is no recognized treatment for arthritis. The researchers looked for safer alternatives, such as herbal medicines, because the traditional treatments used to treat severe joint inflammatory issues have several negative side effects. A ligand-coated nanomedicine
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Exploring the Therapeutic Potential of Flavonoids in the Management of Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-09 Sonia Singh, Riya Verma
:: Flavonoids are a class of polyphenolic compounds that can be classified into six distinct categories, namely isoflavonoids, flavanones, flavanols, flavonols, flavones, and anthocyanidins. These compounds are naturally occurring and can be found in a diverse range of plant species. Flavonoids, a class of bioactive compounds, are mostly obtained through the consumption of vegetables, fruits and plant-derived
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Nanoemulsions a Delivery System in the Making for Tumor Targeting Therapeutics: Evaluation and Characterization to Meet Clinical Challenges Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-03 Ravi Shankar, Prabhat Kumar Upadhyay, Manish Kumar
:: Cancer is a complex disease characterized by the uncontrolled and unregulated growth of cells followed by invasion and proliferation from the site of origin to other sites of the body. Conventional chemotherapy largely kills rapidly expanding and dividing cancer cells by impairing DNA synthesis and mitosis. It is associated with various types of adverse effects ranging from simple nausea and appetite
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Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-03 Aditya Jain, Shikha Yadav, Javed Khan
: Wound healing is crucial for maintaining skin integrity and preventing complications from external threats. Various plants, such as Achillea millefolium, Aloe vera, Curcuma longa, Calendula officinalis, Camellia sinensis, Azadirachta indica, and Plantago, have demonstrated wound healing capabilities and have been used in herbal medicine for wound care. NLCs are second-generation lipid nanoparticles
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Insulin Analogs and the Mode of Insulin Delivery: Recent Advances and Challenges Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-03 Medha Bhagi, Jasmine Kaur, Arti Dhar, Audesh Bhat
: Diabetes is a medical condition associated with impaired glucose regulation caused either due to insufficient insulin production or resistance to insulin (Type 2 diabetes, gestational diabetes) or the absence of insulin through the selective killing of beta cells in the pancreas (Type 1 diabetes). Irregular insulin production leads to various health complications. To prevent such complications, patients
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Potential Serotonin 5-HT2A Receptor Agonist of Psychoactive Components of Silene undulata Aiton: LC-MS/MS, ADMET, and Molecular Docking Studies Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-02 Maram B. Alhawarri, Suleiman Olimat
Background: Silene undulata is historically used for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties. background: Silene undulata has a historical use for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties
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The Neem Limonoid Nimbolide Modulates Key Components of the DNA Damage Response Signalling in Cellular and Animal Models of Oral Squamous Cell Carcinoma Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-02 Soundararajan Arvindh, Manashi Priyadarshini, Abdul Basit Baba, Veeran Veeravarmal, Rajakishore Mishra, Rupesh Dash, Siddavaram Nagini
Background: Ataxia telangiectasia mutated (ATM), DNA damage response, cisplatin, neem, nimbolide, oral squamous cell carcinoma, patient-derived xenograft. Objective: The present study was designed to investigate whether nimbolide, an anticancer neem limonoid, targets key components of the DDR signalling pathway in cellular and animal models of oral squamous cell carcinoma (OSCC). Methods: OSCC cells
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Protective Effects of Curcumin and Nanomicelle Curcumin on Chlorpyrifos-induced Oxidative Damage and Inflammation in the Uterus, Ovary and Brain of Rats Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-02 Maryam Nazarian, Hamed Aramjoo, Babak Roshanravan, Saeed Samarghandian, Tahereh Farkhondeh
Background and aims: Chlorpyrifos (CPF), which is classified as an Organophosphorus Pesticide (OP), has been identified as a toxic agent for the reproductive system due to its capacity to induce oxidative stress and inflammation. Curcumin (CUR) has been reported as a natural antioxidant and anti-inflammatory agent that could combat toxicity in various tissues. This study aims to examine the protective
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Noncoding RNA Lipotherapeutics: A Promising Breakthrough in Pulmonary Hypertension Treatment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-04-02 Xuanyi Hu, Xinxin Lv, Lingzhu Zhang, Shan-Shan Li, Xin Jin
: Pulmonary Hypertension (PH) is a complex cardiovascular disorder characterized by elevated blood pressure in the pulmonary arteries. Current therapeutic approaches for PH have limitations in addressing the underlying molecular mechanisms. This article explores the potential of noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), delivered
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Targeted Drug Delivery to ACE2+ Cells Using Engineered Extracellular Vesicles: A Potential Therapeutic Approach for COVID-19 Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-29 Yao Zhang, Sheng-Jiao Song, Jin He, Zhuo-Hua Zhao, Ke Zhang, Yuan Zhang, Xing Li
Background:: Extracellular vesicles (EVs) are emerging as potential drug carriers in the fight against COVID-19. This study investigates the ability of EVs as drug carriers to target SARS-CoV-2-infected cells. Methods:: EVs were modified using Xstamp technology to carry the virus’s RBD, enhancing targeting ability to hACE2+ cells and improving drug delivery efficiency. Characterization confirmed EVs’
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Research Strategy for Short-Peptide Fusion Inhibitors Based on 6-HB Core Structure against HIV-1: A Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-29 Guodong Liang, Yan Huang, Yanbai Tang, Lu Ga, Caixia Huo, Yuheng Ma, Yan Zhao, Heiya Na, Zhao Meng
: Acquired Immune Deficiency Syndrome (AIDS) is a devastating infectious disease caused by the Human Immunodeficiency Virus type 1 (HIV-1). Enfuvirtide(T20) is the first HIV-1 fusion inhibitor for marketing, which plays an important role in AIDS treatment. However, in the clinical application process, T20 has several drawbacks, such as a high level of development of drug resistance, a short half-life
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Exploring the Diagnostic and Prognostic Predictive Values of Ferroptosis- Related Markers in Lung Adenocarcinoma Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-25 Guoliang Mao, Wuqin Xu, Muhammad Jamil, Wei Zhang, Nanlin Jiao, Yinhua Liu
Background: Lung Adenocarcinoma (LUAD), a common and aggressive form of lung cancer, poses significant treatment challenges due to its low survival rates. Aim: To better understand the role of ferroptosis driver genes in LUAD, this study aimed to explore their diagnostic and prognostic significance, as well as their impact on treatment approaches and tumor immune function in LUAD. Method: To accomplish
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Biofilm Formation in Mycobacterial Genus; Mechanism of Biofilm Formation and Anti-Mycobacterial Biofilm Agents Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-15 Sina Nasrollahian, Hassan Pourmoshtagh, Sahar Sabour, Nahal Hadi, Taher Azimi, Saeed Soleiman-Meigooni
: Mycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria (NTM) are among the most significant human pathogens within the Mycobacterium genus. These pathogens can infect people who come into contact with biomaterials or have chronic illnesses. A characteristic pathogenic trait of mycobacteria is the development of biofilms, which involves several molecules, such as the GroEL1
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Intestinal Epithelial Cell-specific Knockout of METTL3 Aggravates Intestinal Inflammation in CLP Mice by Weakening the Intestinal Barrier Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-14 Hongzhou Shi, Jiahui Sun, Yaya Sun, Junjie Wu, Guangqing Jiang, Zhaiyue Xu, Xin Shi, Miao Fang
Background:: Many studies have demonstrated that the expression of methyltransferase- like 3 (METTL3) is altered in various inflammatory diseases. Its specific mechanistic role in the intestinal inflammatory response during sepsis remains limited and requires further investigation. Objectives:: Explore the potential mechanism of METTL3 in the intestinal inflammatory response during sepsis. Materials
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Unlocking the Potential of RNA Nanoparticles: A Breakthrough Approach to Overcoming Challenges in Colon Cancer Treatment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-14 Dipanjan Karati, Swarupananda Mukherjee, Biswajit Basu, KevinKumar Garala, Ayon Dutta, Bhupendra G. Prajapati, Sankha Bhattacharya
: Globally, one of the leading causes of cancer-related deaths is colon cancer. As this form of cancer has a tremendous potential to metastasize, effective treatment is complicated and sometimes impossible. Despite the improvement of conventional chemotherapy and the advent of targeted therapies, overcoming multi-drug resistance (MDR) and side effects remain significant challenges. As a therapeutic
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Nano-delivery of Silibinin Potentiate the Induction of Immunogenic Cell Death (ICD) in Melanoma Cells Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-14 Mina Amiri, Sevda Jafari, Afsaneh Lavasanifar, Ommoleila Molavi, Soheila Montazersaheb
Background: Induction of immunogenic cell death (ICD) in tumors can enhance antitumor immunity and modulate immunosuppression in the tumor microenvironment (TME). Objective: In the current study, we investigated the effect of silibinin, a natural compound with anticancer activity, and its polymer-based nanoformulations on the induction of apoptosis and ICD in cancer cells. Methods: Free and nanoparticulate
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TP508 Promotes Bone Regeneration on Distraction Osteogenesis via the Activation of Wnt/β-catenin Signaling Pathway Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-12 Kehan Li, Linan Liu, Jingyi Zhang, Chenyu Liao, Jian Hu, Jian Song
Introduction:: TP508 is a thrombin peptide that participates in the inflammatory response and wound healing. Its role in the molecular mechanism of distraction osteogenesis remains unclear. This study established a tibia distraction osteogenesis (DO) model in rats and investigated the role and mechanism of TP508 in bone regeneration during DO. Method:: Micro-computed tomography (Micro-CT) and hematoxylin-eosin
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The Emerging Roles of Circpvt1 in Cancer Progression Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-08 Shijie Wu, Yan Hu, Xiaoyong Lei, Xiaoyan Yang
CircRNA is stable due to its ring structure and is abundant in humans, which not only exists in various tissues and biofluids steadily but also plays a significant role in the physiology and pathology of human beings. CircPVT1, an endogenous circRNA, has recently been identified from the PVT1 gene located in the cancer risk region 8q24. CircPVT1 is reported to be highly expressed in many different
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Marine Microalgae Schizochytrium sp. S31: Potential Source for New Antimicrobial and Antibiofilm Agent Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-07 Doaa Abdullah Hammadi Al-Ogaidi, Sevinç Karaçam, Rafig Gurbanov, Nurcan Vardar-Yel
Background: The rise of antibiotic-resistant bacteria necessitates the discovery of new, safe, and bioactive antimicrobial compounds. The antibacterial and antibiofilm activity of microalgae makes them a potential candidate for developing natural antibiotics to limit microbial infection in various fields. Objective: This study aimed to analyze the antibacterial effect of the methanolic extract of Schizochytrium
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Application of Nanotechnology to Develop Carrageenan-based Films and Coatings as Carriers for Essential Oils Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-05 Leila Nikravan, Setayesh Zamanpour, Mohammad Hashemi, Sayed Mahdi Hossaeini Marashi Marashi, Seyyed Mohammad Ali Noori
: This review highlights the effect of combining bioactive agents, especially nanoparticles, in carrageenan coating to increase the quality and stability of foods. This study is designed based on a review of previous studies. Biopolymer coatings and films are suitable for food and non-food packaging due to their degradability, renewable and edible nature. Edible coatings and films are based on polysaccharides
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Nanotheranostics: A Cutting-Edge Technology for Cancer Management Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-05 Shwetapadma Dash, Shasank Sekhar Swain, Auromira Khuntia, Sneha Dutta, Sanjeeb Kumar Sahoo
: Cancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore
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In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Chun-Xia Wang, Hsiang-Hung Cheng, Mei Luo, Jing-Rong Jiang
: Rheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-KB signaling pathway in RA has emerged as a crucial research area for the development of RA therapies, with non-coding RNAs (ncRNAs) serving as a potentially meaningful avenue to regulate it. Thus, understanding
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The Hepatoprotective Effects of Ginsenoside from Ginseng: A Review of Molecular Mechanisms and Therapeutic Potentials Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Seyed Reza Taha, Andarz Fazlollahpour-Naghibi, Mahdieh Shariat Zadeh, Kimia Bagheri, Hamed Rahmani Youshanlouei, Reza Mosaddeghi-Heris, Seyyed Sina Hejazian, Amirreza Khalaji, Seyedeh Shaghayegh Alavi, Payam Fattahi, Saba Mehrtabar
: Treatment of hepatic diseases presents a significant challenge due to their diverse nature. Ginsenosides, bioactive compounds derived from the root of Panax ginseng and widely used in traditional Chinese medicine, offer multifaceted protection to various organs in the body. Their versatile effects, including antioxidant, anti-inflammatory, anti-apoptotic and more, make them a promising approach for
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Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Nurhanan Murni Yunos, Mohammad Gasem Al-Thiabat, Nor Jannah Sallehudin, Habibah A Wahab
Background:: Quassinoids are degraded triterpene compounds that can be obtained from various species of the Simaroubaceae plant family, including Eurycoma longifolia. Quassinoids are the major compounds in E. longifolia, and they are known to have various medicinal potentials, such as anticancer and antimalarial properties. Dihydrofolate reductase (DHFR) was reported to be one of the important targets
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Non-Receptor Type PTPases and their Role in Controlling Pathways Related to Diabetes and Liver Cancer Signalling Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Nidhee Chaudhary, Bellam Kiranmayee
: The role of non-receptor type Protein Tyrosine Phosphatase (PTPases) in controlling pathways related to diabetes and Hepatocellular Carcinoma (HCC) is significant. The insulin signal transduction pathway is regulated by the steady-state phosphorylation of tyrosyl residues of the insulin receptor and post-receptor substrates. PTPase has been shown to have a physiological role in the regulation of
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MFAP5 Strengthened the Stem Cell Features of Non-small Cell Lung Cancer Cells by Regulating the FBW/Sox9 Axis Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-28 Chun Du, Zijuan Qi, Wei Zhang
Introduction: Non-small cell lung cancer (NSCLC) is a type of malignant tumor with high morbidity as well as mortality. The process of lung cancer may be driven by cancer stem cells. It was known that MFAP5 enhanced the occurrence of diverse types of cancer. Also, MFAP5 has the potential to induce the degradation of FBW7 which is a tumor suppressor. Lower levels of FBW7 enhance the stability of Sox9
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An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-28 Virender Kumar, Vandana Garg, Nakul Saini, Navidha Aggarwal, Harsh Kumar, Davinder Kumar, Hitesh Chopra, Mohammad Amjad Kamal, Harish Dureja
Background: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of nanoemulsions and how they can be applied to various applications such as drug delivery, food applications, and pesticide formulations. Objective: This updated
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Recent Developments in Nanotechnology and Immunotherapy for the Diagnosis and Treatment of Pancreatic Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-28 Komal Sindhi, Abhishek Kanugo
: Pancreatic cancer kills millions of people worldwide each year and is one of the most prevalent causes of mortality that requires prompt therapy. A large number of people who have pancreatic cancer are detected at an advanced stage, with incurable and drug-resistant tumors. Hence the overall survival rate of pancreatic cancer is less. The advance phase of this cancer is generated because of the expression
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Diagnosis of Canine Visceral Leishmaniasis by Flow Cytometry Serology using the rMELEISH Multiepitope Antigen Coupled in a Functional Bead Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-27 Henrique Bonifácio Moura, Henrique Gama Ker, Luana S. Ramos, Lais M. Nogueira, Juliana M. Machado, Daniel S. Dias, Rita Alaíde Leandro Rodrigues, Mariana Campos da Paz, Rafael Gonçalves Teixeira-Neto, Alexandre Barbosa Reis, Alexsandro S. Galdino, Eduardo S. Silva
Background:: Visceral leishmaniasis (VL) is a zoonotic disease, with dogs being the main reservoir of the Leishmania infantum parasite. Objective:: To develop a new flow cytometry test to diagnosis canine VL (CVL) diagnosis. Methods:: The current study addresses a new flow cytometry test using beads coupled to the multiepitope antigen rMELEISH. Results:: In the study set of samples a sensitivity (87
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Role of Protein Ubiquitination and HIF Signaling in the Evolution of Hypoxic Breast Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-27 Suman Kumar Ray, Sukhes Mukherjee
: Alternations in protein ubiquitination along with hypoxia-inducible factor (HIF) signaling contribute to tumorigenesis and breast tumor advancement. Ubiquitination is an impulsive process, which is coordinately governed by E3 ligases and deubiquitinases (DUBs), that have come out as charismatic therapeutic targets. HIF expression, as well as the transcriptional process in malignancies, are frequently
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Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-22 Nahid Jivad, Saeid Heidari-Soureshjani, Hesamaldin Bagheri, Catherine MT Sherwin, Sahar Rostamian
Background:: Epilepsy is one of the most common in all age groups and disabling neurologic disorders around the world. Objectives:: This systematic review was to explore whether berberine (BBR) has any anti-seizure or anti-epileptic effects and also reviewed this possible mechanism. Methods:: The EMBASE, Scopus, Cochrane Library, PubMed, and Web of Science databases were searched before Sep 2023. All
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Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-20 Suqin Zhang, Yanbin Li, Qiuyue Wang
Background: Renal tubular epithelial cells (RTECs) senescence is crucial in kidney diseases. Icariin is shown to have protective effects against renal fibrosis, acute kidney injury, and proteinuria. We aimed to explore the role of icariin in protecting RTECs from senescence and the underlying mechanism involved. Methods: An in vitro model of RTEC senescence was established by incubating HK-2 cells
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Unconventional Remedies for Squamous Cell Carcinoma: A Journey into Alternative Treatments Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-16 Elen Deng, Amor Kachemoune
: Squamous cell carcinoma (SCC) is the second most common form of skin cancer and is typically found on sun-exposed skin. Risk factors include ultraviolet radiation exposure, older age, fairer complexion, smoking, and immunosuppression. SCC is a slow-growing tumor with the possibility of metastasis if not treated. The clinical presentation can range from a dry, scaly erythematous patch or plaque to
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The Use of Lipid-Based Nanocarriers to Improve Ovarian Cancer Treatment: An Overview of Recent Developments Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-15 Junaid Tantray, Akhilesh Patel, Bhupendra G. Prajapati, Sourabh Kosey, Sankha Bhattacharya
: Ovarian cancer poses a formidable health challenge for women globally, necessitating innovative therapeutic approaches. This review provides a succinct summary of the current research status on lipid-based nanocarriers in the context of ovarian cancer treatment. Lipid-based nanocarriers, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), offer a promising
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The Role of NAD+ in Myocardial Ischemia-induced Heart Failure in Sprague-Dawley Rats and Beagles Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-15 Zuowei Pei, Chenguang Yang, Ying Guo, Min Dong, Fang Wang
Introduction: Nicotinamide adenine dinucleotide (NAD+) participates in various processes that are dysregulated in cardiovascular diseases. Supplementation with NAD+ may be cardioprotective. However, whether the protective effect exerted by NAD+ in heart failure (HF) is more effective before acute myocardial infarction (MI) or after remains unclear. The left anterior descending arteries of male Sprague
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Determination of Ideal Factors for Early Adoption and Standardization of Metagenomic Next-Generation Sequencing for Respiratory System Infections Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-14 Lei Zhao, Cole R. Formslag, Qing Zhang, Braydon C. Cowan, Trenton G. Mayberry, Aaron R. Barnhill, Yongsheng Wang, Yujiang Fang
Background: Metagenomic next-generation sequencing (mNGS) demonstrates great promise as a diagnostic tool for determining the cause of pathogenic infections. The standard diagnostic procedures (SDP) include smears and cultures and are typically viewed as less sensitive and more time-consuming when compared to mNGS. There are concerns about the logistics and ease of transition from SDP to mNGS. mNGS
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Implementation of Silver Nanoparticles Green Synthesized with Leaf Extract of Coccinia grandis as Antimicrobial Agents Against Head and Neck Infection MDR Pathogens Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-14 Smarita Lenka, Debasmita Dubey, Santosh Kumar Swain, Goutam Rath, Ajit Mishra, Ajit Kumar Bishoyi, Gopal Krishna Purohit
Background: Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. background: Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. Objectives: This study aimed to identify the bacteria and Candidal isolates and
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Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-13 Lanlan Li, Yutong Ran, Jiao Wen, Yirui Lu, Shunmei Liu, Hong Li, Min Cheng
: Cardiovascular Disease (CVD) is the leading cause of morbidity and death worldwide and has become a global public health problem. Traditional Chinese medicine (TCM) has been used in China to treat CVD and achieved promising results. Therefore, TCM has aroused significant interest among pharmacologists and medical practitioners. Previous research showed that TCM can regulate the occurrence and development
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Naringenin Nanoformulations for Neurodegenerative Diseases Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-13 Liza Sahoo, Nigam Sekhar Tripathy, Fahima Dilnawaz
: Glioblastoma (GBM) is a grade-IV astrocytoma, which is the most common and aggressive type of brain tumor, spreads rapidly and has a life-threatening catastrophic effect. GBM mostly occurs in adults with an average survival time of 15 to 18 months, and the overall mortality rate is 5%. Significant invasion and drug resistance activity cause the poor diagnosis of GBM. Naringenin (NRG) is a plant secondary
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RNA-Based Therapeutics: Past, Present and Future Prospects, Challenges in Cancer Treatment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-13 Anjana Goel, Amisha Rastogi, Mansi Jain, Kinjal Niveriya
abstract: It is becoming more and harder in today's climate to disregard the impact of cancer on social health. Even though a significant amount of money is spent annually on cancer research, it still ranks as the second leading cause of death worldwide. Additionally, only about half of the patients suffering from complex forms of cancer survive a year after receiving traditional cancer therapies.
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Long Non-coding RNA DLEU1 Promotes Progression of Osteoarthritis via miR-492/TLR8 Axis Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-07 Chenzhe Ni, Wanglin Zhang, Sai Qiu, Hao Cheng, Chunhui Ma
Background: Long non-coding RNAs (LncRNAs) are generally reported to participate in the development of Osteoarthritis (OA) by acting as competing endogenous RNAs (ceRNAs). However, the molecular mechanism is largely unknown. This study aimed to investigate the possible mechanisms contributing to osteoarthritis (OA). Methods: Four gene expression profiles from patients with OA were downloaded from a
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Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-07 Thais Silva Correa, William Gustavo Lima, Aline Beatriz do Couto Campos, Alexsandro Sobreira Galdino, Emilia Celma de Oliveira Lima, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Mariana Campos-da-Paz
Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium–99m (99mTc)
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Deciphering Immune-Related Gene Signatures in Diabetic Retinopathy: Insights from In Silico Analysis and In vitro Experiment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Nan Xia, Qingsong Zhao, Jinmei Xu, Zhifeng Cheng
Background: Diabetes retinopathy (DR) is one of the most common microvascular consequences of diabetes, and the economic burden is increasing. Our aim is to decipher the relevant mechanisms of immune-related gene features in DR and explore biomarkers targeting DR. Provide a basis for the treatment and prevention of DR. background: Diabetic retinopathy (DR) is one of the most prevalent microvascular
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An Update to Novel Therapeutic Options for Combating Tuberculosis: Challenges and Future Prospectives Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Swathi Suresh, Rukaiah Fatma Begum, Ankul Singh S., Chitra Vellapandian
: Drug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies, repurposed drugs, and drugs
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Harnessing Chimeric Antigen Receptor-engineered Invariant Natural Killer T Cells: Therapeutic Strategies for Cancer and the Tumor Microenvironment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Yiqing Wang, Yan-Ruide Li
: Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has emerged as a revolutionary approach for cancer treatment, especially for hematologic cancers. However, CAR-T therapy has some limitations, including cytokine release syndrome (CRS), immune cellassociated neurologic syndrome (ICANS), and difficulty in targeting solid tumors and delivering allogeneic cell therapy due to graft-versus-host
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Recent Insight into Herbal Bioactives-Based Novel Approaches for Chronic Intestinal Inflammatory Disorders Therapy Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Ranjit K. Harwansh, Sonia Chauhan, Rohitas Deshmukh, Rupa Mazumder
: Inflammatory bowel disease (IBD) is a life-threatening complex disease. It causes chronic intestinal inflammation in GIT. IBD significantly affects people’s lifestyles and carries a high risk of colon cancer. IBD involves the rectum, ileum, and colon, with clinical manifestations of bloody stools, weight loss, diarrhea, and abdominal pain. The prevalence of inflammatory disease is increasing dramatically
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Single Nucleotide Polymorphisms [SNPs] in the Shadows: Uncovering their Function in Non-Coding Region of Esophageal Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Surovi Saikia, Humzah Postwala, Vishnu Prabhu Athilingam, Aparna A, V. Vijaya Padma, Partha P. Kalita, Mehul Chorawala, Bhupendra Prajapati
: Esophageal cancer is a complex disease influenced by genetic and environmental factors. Single nucleotide polymorphisms [SNPs] in non-coding regions of the genome have emerged as crucial contributors to esophageal cancer susceptibility. This review provides a comprehensive overview of the role of SNPs in non-coding regions and their association with esophageal cancer. The accumulation of SNPs in
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Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Omid-Ali Adeli, Saeid Heidari-Soureshjani, Sahar Rostamian, Zahra Azadegan-Dehkordi, Armin Khaghani
Background: Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function. Objectives: This systematic review study investigated fisetin's effects and possible mechanisms in attenuating myocardial, cerebral, renal, and hepatic IRIs. Methods: This systematic review included studies earlier than Sep 2023 by following the PRISMA statement 2020. After determining inclusion and
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Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Tat'yana Grigorievna Khonina, Denis Sergeevich Tishin, Leonid Petrovich Larionov, Artur Vasilevich Osipenko, Maria Nikolaevna Dobrinskaya, Ekaterina Anatolievna Bogdanova, Maxim Sergeevich Karabanalov, Maria Alekseevna Bulatova, Elena Vladimirovna Shadrina, Oleg Nikolaevich Chupakhin
Background: Nanocomposite glycerohydrogels based on biocompatible elementcontaining glycerolates are of practicular interest for biomedical applications. Objective: Using two biocompatible precursors, silicon and iron glycerolates, a new bioactive nanocomposite silicon‒iron glycerolates hydrogel was obtained by sol-gel method. Methods: The composition and structural features of the hydrogel were studied
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Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Rashi Kulshrestha, Neelam Singla, Obaid Afzal, Ahsas Goyal, Mahendra Saini, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan almalki, Imran Kazmi, Fahad Al-Abbasi, Sami I. Alzarea, Gaurav Gupta
: Drug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies, repurposed drugs, and drugs
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Essential Oils of Some Potential Medicinal Plants and Their Wound Healing Activities Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Shiv Bahadur, Sana Fatima
: The wound has been recognised as a deep cut or tearing of the epidermis, which is also referred to as trauma and harm to the body tissues. Healing of wounds requires a coordinated series of cellular processes, including cell attraction, proliferation, differentiation, and angiogenesis. These processes involve interactions between various cells, such as macrophages, endothelial cells, keratinocytes
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Emerging Therapeutic Approaches Targeting Ferroptosis in Cancer: Focus on Immunotherapy and Nanotechnology Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Zongchao Yu, Zhongcheng Mo, Yuan Qiu, Hengzhe Lu, Biao Zheng, Longfei Liu
: Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung
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The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Mohaddeseh Bahmani, Saba Mehrtabar, Ali Jafarizadeh, Sevda Zoghi, Fatemah Sadeghpour Heravi, Amin Abbasi, Sarvin Sanaie, Sama Rahnemayan, Hamed Ebrahimzadeh Leylabadlo
: Major depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved in human physiological health. The interaction of gut microbiota components and metabolic products
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Overcoming Low Adherence to Chronic Medications by Improving their Effectiveness Using a Personalized Second-generation Digital System Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Areej Bayatra, Rima Nasserat, Yaron Ilan
Introduction: Low adherence to chronic treatment regimens is a significant barrier to improving clinical outcomes in patients with chronic diseases. Low adherence is a result of multiple factors. Methods: We review the relevant studies on the prevalence of low adherence and present some potential solutions. Results: This review presents studies on the current measures taken to overcome low adherence